Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

Objective. Ovarian torsion is a gynecological emergency that occurs mostly during the female reproductive years due to ovarian masses or surgical manipulation. This work aims to explore the probable protective effect of leptin on rat ovaries due to ischemia-reperfusion (IR) injury.

Bibliographic Details
Main Authors: Abdel-Hamid Heba A., Maqsoud Nehad MR. Abdel, Toni Nisreen DM., Ahmed Rasha F., Abdel-Hakeem Elshymaa A.
Format: Article
Language:English
Published: Sciendo 2023-01-01
Series:Endocrine Regulations
Subjects:
ischemia
reperfusion
ovary
leptin
sirtuin 1
toll like receptor-4
Online Access:https://doi.org/10.2478/enr-2023-0004
Description
Summary:Objective. Ovarian torsion is a gynecological emergency that occurs mostly during the female reproductive years due to ovarian masses or surgical manipulation. This work aims to explore the probable protective effect of leptin on rat ovaries due to ischemia-reperfusion (IR) injury.
ISSN:1336-0329

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