Assessing comparative importance of DNA sequence and epigenetic modifications on gene expression using a deep convolutional neural network

Assessing comparative importance of DNA sequence and epigenetic modifications on gene expression using a deep convolutional neural network

Gene expression is regulated at both transcriptional and post-transcriptional levels. DNA sequence and epigenetic modifications are key factors which regulate gene transcription. Understanding their complex interactions and their respective contributions to gene expression regulation remains a chall...

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Bibliographic Details
Main Authors: Shang Gao, Jalees Rehman, Yang Dai
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Epigenetic modifications
DNA sequence
Transcription factors
Multi-omics
Deep convolutional neural network
Deep learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022002938

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http://www.sciencedirect.com/science/article/pii/S2001037022002938

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