A model of traumatic brain injury in rats is influenced by neuroprotection of diurnal variation which improves motor behavior and histopathology in white matter myelin
Traumatic brain injury (TBI) represents a significant public health concern and has been associated with high rates of morbidity and mortality. TBI generates two types of brain damage: primary and secondary. Secondary damage originates a series of pathophysiological processes, which include metaboli...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023032954 |
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| author | R.J. Martínez-Tapia F. Estrada-Rojo T.G. López-Aceves S. García-Velasco V. Rodríguez-Mata E. Pulido-Camarillo A. Pérez-Torres E.Y. López-Flores P. Ugalde-Muñiz R. Noriega-Navarro L. Navarro |
| author_facet | R.J. Martínez-Tapia F. Estrada-Rojo T.G. López-Aceves S. García-Velasco V. Rodríguez-Mata E. Pulido-Camarillo A. Pérez-Torres E.Y. López-Flores P. Ugalde-Muñiz R. Noriega-Navarro L. Navarro |
| author_sort | R.J. Martínez-Tapia |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) represents a significant public health concern and has been associated with high rates of morbidity and mortality. TBI generates two types of brain damage: primary and secondary. Secondary damage originates a series of pathophysiological processes, which include metabolic crisis, excitotoxicity, and neuroinflammation, which have deleterious consequences for neuronal function. However, neuroprotective mechanisms are also activated. The balance among these tissue responses, and its variations throughout the day determines the fate of the damage tissue. We have demonstrated less behavioral and morphological damage when a rat model of TBI was induced during the light hours of the day.Moreover, here we show that rats subjected to TBI in the dark lost less body weight than those subjected to TBI in the light, despite no change in food intake. Besides, the rats subjected to TBI in the dark had better performance in the beam walking test and presented less histological damage in the corpus callosum and the cingulum bundle, as shown by the Klüver-Barrera staining.Our results suggest that the time of day when the injury occurs is important. Thus, this data should be used to evaluate the pathophysiological processes of TBI events and develop better therapies. |
| first_indexed | 2024-03-13T08:25:21Z |
| format | Article |
| id | doaj.art-ef15545157164f3ea3c5b09341f5309d |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:25:21Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ef15545157164f3ea3c5b09341f5309d2023-05-31T04:46:35ZengElsevierHeliyon2405-84402023-05-0195e16088A model of traumatic brain injury in rats is influenced by neuroprotection of diurnal variation which improves motor behavior and histopathology in white matter myelinR.J. Martínez-Tapia0F. Estrada-Rojo1T.G. López-Aceves2S. García-Velasco3V. Rodríguez-Mata4E. Pulido-Camarillo5A. Pérez-Torres6E.Y. López-Flores7P. Ugalde-Muñiz8R. Noriega-Navarro9L. Navarro10Laboratory of Neuroendocrinology, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, MexicoLaboratory of Neuroendocrinology, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, MexicoLaboratory of Neuroendocrinology, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico; Programa Regional de Posgrado en Biotecnología, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, MexicoLaboratory of Neuroendocrinology, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, MexicoDepartamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoDepartamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoDepartamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoResidente de Anatomía Patológica, CMN “20 de Noviembre”, ISSSTE, Ciudad de México, MexicoLaboratory of Neuroendocrinology, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, MexicoLaboratory of Neuroendocrinology, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, MexicoLaboratory of Neuroendocrinology, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City, Mexico; Corresponding authorTraumatic brain injury (TBI) represents a significant public health concern and has been associated with high rates of morbidity and mortality. TBI generates two types of brain damage: primary and secondary. Secondary damage originates a series of pathophysiological processes, which include metabolic crisis, excitotoxicity, and neuroinflammation, which have deleterious consequences for neuronal function. However, neuroprotective mechanisms are also activated. The balance among these tissue responses, and its variations throughout the day determines the fate of the damage tissue. We have demonstrated less behavioral and morphological damage when a rat model of TBI was induced during the light hours of the day.Moreover, here we show that rats subjected to TBI in the dark lost less body weight than those subjected to TBI in the light, despite no change in food intake. Besides, the rats subjected to TBI in the dark had better performance in the beam walking test and presented less histological damage in the corpus callosum and the cingulum bundle, as shown by the Klüver-Barrera staining.Our results suggest that the time of day when the injury occurs is important. Thus, this data should be used to evaluate the pathophysiological processes of TBI events and develop better therapies.http://www.sciencedirect.com/science/article/pii/S2405844023032954Traumatic brain injuryDiurnal variationWhite matterMyelinNeuroprotection |
| spellingShingle | R.J. Martínez-Tapia F. Estrada-Rojo T.G. López-Aceves S. García-Velasco V. Rodríguez-Mata E. Pulido-Camarillo A. Pérez-Torres E.Y. López-Flores P. Ugalde-Muñiz R. Noriega-Navarro L. Navarro A model of traumatic brain injury in rats is influenced by neuroprotection of diurnal variation which improves motor behavior and histopathology in white matter myelin Heliyon Traumatic brain injury Diurnal variation White matter Myelin Neuroprotection |
| title | A model of traumatic brain injury in rats is influenced by neuroprotection of diurnal variation which improves motor behavior and histopathology in white matter myelin |
| title_full | A model of traumatic brain injury in rats is influenced by neuroprotection of diurnal variation which improves motor behavior and histopathology in white matter myelin |
| title_fullStr | A model of traumatic brain injury in rats is influenced by neuroprotection of diurnal variation which improves motor behavior and histopathology in white matter myelin |
| title_full_unstemmed | A model of traumatic brain injury in rats is influenced by neuroprotection of diurnal variation which improves motor behavior and histopathology in white matter myelin |
| title_short | A model of traumatic brain injury in rats is influenced by neuroprotection of diurnal variation which improves motor behavior and histopathology in white matter myelin |
| title_sort | model of traumatic brain injury in rats is influenced by neuroprotection of diurnal variation which improves motor behavior and histopathology in white matter myelin |
| topic | Traumatic brain injury Diurnal variation White matter Myelin Neuroprotection |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023032954 |
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