Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin
Pineal metastasis is an exceedingly rare finding in patients with systemic malignancies. Such lesions are typically the manifestation of a primary lung cancer; nonetheless, a variety of malignancies have been reported to disseminate to the pineal gland including gastrointestinal, endocrine, and skin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2020.597773/full |
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| author | Joshua A. Cuoco Joshua A. Cuoco Joshua A. Cuoco Michael W. Kortz Michael W. Kortz Michael J. Benko Michael J. Benko Michael J. Benko Robert W. Jarrett Robert W. Jarrett Cara M. Rogers Cara M. Rogers Cara M. Rogers Mark R. Witcher Mark R. Witcher Mark R. Witcher Eric A. Marvin Eric A. Marvin Eric A. Marvin |
| author_facet | Joshua A. Cuoco Joshua A. Cuoco Joshua A. Cuoco Michael W. Kortz Michael W. Kortz Michael J. Benko Michael J. Benko Michael J. Benko Robert W. Jarrett Robert W. Jarrett Cara M. Rogers Cara M. Rogers Cara M. Rogers Mark R. Witcher Mark R. Witcher Mark R. Witcher Eric A. Marvin Eric A. Marvin Eric A. Marvin |
| author_sort | Joshua A. Cuoco |
| collection | DOAJ |
| description | Pineal metastasis is an exceedingly rare finding in patients with systemic malignancies. Such lesions are typically the manifestation of a primary lung cancer; nonetheless, a variety of malignancies have been reported to disseminate to the pineal gland including gastrointestinal, endocrine, and skin cancers, among others. However, to our knowledge, pineal gland metastasis without a primary origin has yet to be described. Carcinoma of unknown primary origin is a heterogeneous group of cancers characterized by the presence of metastatic disease without an identifiable primary tumor on metastatic workup. Here, we present a case of a 65-year-old male found to have a heterogeneously enhancing lesion of the pineal gland as well as an enhancing lesion of the left cerebellar hemisphere. Comprehensive metastatic workup demonstrated multifocal metastatic adenopathy without an identifiable primary lesion. Stereotactic biopsy of the pineal lesion revealed poorly differentiated carcinoma with an immunophenotype most consistent with gastrointestinal origin. To our knowledge, this is the first case to describe a pineal gland metastasis without a primary origin. We discuss the relevant literature on pineal gland metastases as well as carcinoma of unknown primary origin. |
| first_indexed | 2024-12-20T16:10:54Z |
| format | Article |
| id | doaj.art-ef16d74e739e4b518bdd71fe66a11e1b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-20T16:10:54Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ef16d74e739e4b518bdd71fe66a11e1b2022-12-21T19:33:59ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-10-011110.3389/fendo.2020.597773597773Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary OriginJoshua A. Cuoco0Joshua A. Cuoco1Joshua A. Cuoco2Michael W. Kortz3Michael W. Kortz4Michael J. Benko5Michael J. Benko6Michael J. Benko7Robert W. Jarrett8Robert W. Jarrett9Cara M. Rogers10Cara M. Rogers11Cara M. Rogers12Mark R. Witcher13Mark R. Witcher14Mark R. Witcher15Eric A. Marvin16Eric A. Marvin17Eric A. Marvin18Section of Neurosurgery, Carilion Clinic, Roanoke, VA, United StatesVirginia Tech Carilion School of Medicine, Roanoke, VA, United StatesSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, United StatesDepartment of Neurosurgery, University of Colorado, Aurora, CO, United StatesCollege of Osteopathic Medicine, Kansas City University, Kansas City, MO, United StatesSection of Neurosurgery, Carilion Clinic, Roanoke, VA, United StatesVirginia Tech Carilion School of Medicine, Roanoke, VA, United StatesSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, United StatesVirginia Tech Carilion School of Medicine, Roanoke, VA, United StatesDepartment of Pathology, Carilion Clinic, Roanoke, VA, United StatesSection of Neurosurgery, Carilion Clinic, Roanoke, VA, United StatesVirginia Tech Carilion School of Medicine, Roanoke, VA, United StatesSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, United StatesSection of Neurosurgery, Carilion Clinic, Roanoke, VA, United StatesVirginia Tech Carilion School of Medicine, Roanoke, VA, United StatesSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, United StatesSection of Neurosurgery, Carilion Clinic, Roanoke, VA, United StatesVirginia Tech Carilion School of Medicine, Roanoke, VA, United StatesSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, United StatesPineal metastasis is an exceedingly rare finding in patients with systemic malignancies. Such lesions are typically the manifestation of a primary lung cancer; nonetheless, a variety of malignancies have been reported to disseminate to the pineal gland including gastrointestinal, endocrine, and skin cancers, among others. However, to our knowledge, pineal gland metastasis without a primary origin has yet to be described. Carcinoma of unknown primary origin is a heterogeneous group of cancers characterized by the presence of metastatic disease without an identifiable primary tumor on metastatic workup. Here, we present a case of a 65-year-old male found to have a heterogeneously enhancing lesion of the pineal gland as well as an enhancing lesion of the left cerebellar hemisphere. Comprehensive metastatic workup demonstrated multifocal metastatic adenopathy without an identifiable primary lesion. Stereotactic biopsy of the pineal lesion revealed poorly differentiated carcinoma with an immunophenotype most consistent with gastrointestinal origin. To our knowledge, this is the first case to describe a pineal gland metastasis without a primary origin. We discuss the relevant literature on pineal gland metastases as well as carcinoma of unknown primary origin.https://www.frontiersin.org/articles/10.3389/fendo.2020.597773/fullpineal glandneuroendocrinologycancer endocrinologycarcinoma of unknown primary (CUP)metastasis |
| spellingShingle | Joshua A. Cuoco Joshua A. Cuoco Joshua A. Cuoco Michael W. Kortz Michael W. Kortz Michael J. Benko Michael J. Benko Michael J. Benko Robert W. Jarrett Robert W. Jarrett Cara M. Rogers Cara M. Rogers Cara M. Rogers Mark R. Witcher Mark R. Witcher Mark R. Witcher Eric A. Marvin Eric A. Marvin Eric A. Marvin Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin Frontiers in Endocrinology pineal gland neuroendocrinology cancer endocrinology carcinoma of unknown primary (CUP) metastasis |
| title | Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin |
| title_full | Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin |
| title_fullStr | Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin |
| title_full_unstemmed | Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin |
| title_short | Pineal Gland Metastasis From Poorly Differentiated Carcinoma of Unknown Primary Origin |
| title_sort | pineal gland metastasis from poorly differentiated carcinoma of unknown primary origin |
| topic | pineal gland neuroendocrinology cancer endocrinology carcinoma of unknown primary (CUP) metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2020.597773/full |
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