Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases
Few studies have assessed the association between fine particulate matter (PM2.5) exposure during pregnancy and infancy and pediatric rheumatic diseases (PRDs). The goal of this study was to investigate the association of PM2.5 with PRDs, and to explore sensitive windows of exposure. Therefore, we c...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-05-01
|
| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019330806 |
| _version_ | 1828485885154295808 |
|---|---|
| author | Chi-Min Wang Chau-Ren Jung Wei-Ting Chen Bing-Fang Hwang |
| author_facet | Chi-Min Wang Chau-Ren Jung Wei-Ting Chen Bing-Fang Hwang |
| author_sort | Chi-Min Wang |
| collection | DOAJ |
| description | Few studies have assessed the association between fine particulate matter (PM2.5) exposure during pregnancy and infancy and pediatric rheumatic diseases (PRDs). The goal of this study was to investigate the association of PM2.5 with PRDs, and to explore sensitive windows of exposure. Therefore, we conducted a cohort-based case-control study to investigate the association between weekly exposure to PM2.5 and PRDs in Taiwan. Our birth cohort consisted of infants born in 2004–2014 (n = 1,991,592) who were followed from conception to the end of 2015. There were 2363 cases of incident PRDs in children, and 23,630 children served as controls using density matching (1:10) based on date of birth, gender, and gestational week. We used a linear mixed effect (LME) model to incorporate the aerosol optical depth (AOD), meteorological variables, and land-use data to predict daily PM2.5 concentrations. We also performed conditional logistic regression with distributed lag non-linear models (DLNMs) to assess the effects of weekly average PM2.5 on PRDs, as well as dose-response relationships. In DLNMs, exposure to PM2.5 during pregnancy (11–40 weeks) or infancy (1–14 weeks after birth) was associated with incident PRDs adjusting for potential confounding factors, and for carbon monoxide and sulfur dioxide. In the dose-response association, the odds ratios of PRDs were significantly increased for PM2.5 exposures between 26 and 54 μg/m3. In addition, exposure to PM2.5 above 81 μg/m3 dramatically increased the risk of PRDs. In conclusions, our study provides new data to suggest that PM2.5 exposure from 11–40 gestational weeks to 1–14 weeks after birth can increase the risk for PRDs in a non-linear dose-response fashion. Keywords: Autoimmune, Cohort-based case-control study, Pediatric rheumatic diseases, PM2.5, Satellite-based estimation model |
| first_indexed | 2024-12-11T09:23:12Z |
| format | Article |
| id | doaj.art-ef1896bae7124f0c883a26633fa0d0c4 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-11T09:23:12Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-ef1896bae7124f0c883a26633fa0d0c42022-12-22T01:13:13ZengElsevierEnvironment International0160-41202020-05-01138Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseasesChi-Min Wang0Chau-Ren Jung1Wei-Ting Chen2Bing-Fang Hwang3Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, TaiwanDepartment of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan; Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Tsukuba, JapanDepartment of Atmospheric Sciences, National Taiwan University, Taipei, TaiwanDepartment of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan; Department of Occupational Therapy, College of Medical and Health Science, Asia University, Taichung, Taiwan; Corresponding author at: Department of Occupational Safety and Health, College of Public Health, China Medical University, No 91 Hsueh-Shih Rd, Taichung 40402, Taiwan.Few studies have assessed the association between fine particulate matter (PM2.5) exposure during pregnancy and infancy and pediatric rheumatic diseases (PRDs). The goal of this study was to investigate the association of PM2.5 with PRDs, and to explore sensitive windows of exposure. Therefore, we conducted a cohort-based case-control study to investigate the association between weekly exposure to PM2.5 and PRDs in Taiwan. Our birth cohort consisted of infants born in 2004–2014 (n = 1,991,592) who were followed from conception to the end of 2015. There were 2363 cases of incident PRDs in children, and 23,630 children served as controls using density matching (1:10) based on date of birth, gender, and gestational week. We used a linear mixed effect (LME) model to incorporate the aerosol optical depth (AOD), meteorological variables, and land-use data to predict daily PM2.5 concentrations. We also performed conditional logistic regression with distributed lag non-linear models (DLNMs) to assess the effects of weekly average PM2.5 on PRDs, as well as dose-response relationships. In DLNMs, exposure to PM2.5 during pregnancy (11–40 weeks) or infancy (1–14 weeks after birth) was associated with incident PRDs adjusting for potential confounding factors, and for carbon monoxide and sulfur dioxide. In the dose-response association, the odds ratios of PRDs were significantly increased for PM2.5 exposures between 26 and 54 μg/m3. In addition, exposure to PM2.5 above 81 μg/m3 dramatically increased the risk of PRDs. In conclusions, our study provides new data to suggest that PM2.5 exposure from 11–40 gestational weeks to 1–14 weeks after birth can increase the risk for PRDs in a non-linear dose-response fashion. Keywords: Autoimmune, Cohort-based case-control study, Pediatric rheumatic diseases, PM2.5, Satellite-based estimation modelhttp://www.sciencedirect.com/science/article/pii/S0160412019330806 |
| spellingShingle | Chi-Min Wang Chau-Ren Jung Wei-Ting Chen Bing-Fang Hwang Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases Environment International |
| title | Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases |
| title_full | Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases |
| title_fullStr | Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases |
| title_full_unstemmed | Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases |
| title_short | Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases |
| title_sort | exposure to fine particulate matter pm2 5 and pediatric rheumatic diseases |
| url | http://www.sciencedirect.com/science/article/pii/S0160412019330806 |
| work_keys_str_mv | AT chiminwang exposuretofineparticulatematterpm25andpediatricrheumaticdiseases AT chaurenjung exposuretofineparticulatematterpm25andpediatricrheumaticdiseases AT weitingchen exposuretofineparticulatematterpm25andpediatricrheumaticdiseases AT bingfanghwang exposuretofineparticulatematterpm25andpediatricrheumaticdiseases |