Liver biopsy is still needed in liver transplantation recipients: a single center experience
Abstract Background Liver transplantation is a final treatment for decompensated liver disease. Aim Description of post-liver transplant histopathology. We enrolled 89 patients divided into two groups according to if they underwent on demand liver biopsy (n = 34; 38.2%) or not (n = 55; 61.8%). Album...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2020-05-01
|
| Series: | Egyptian Liver Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43066-020-00031-1 |
| _version_ | 1818033554502713344 |
|---|---|
| author | Eman Abdelsameea Ayman Alsebaey Nermine Ehsan Ahmed Elrefaey Khalid Aboelela El-Sayed Ibrahim Maha Elsabaawy |
| author_facet | Eman Abdelsameea Ayman Alsebaey Nermine Ehsan Ahmed Elrefaey Khalid Aboelela El-Sayed Ibrahim Maha Elsabaawy |
| author_sort | Eman Abdelsameea |
| collection | DOAJ |
| description | Abstract Background Liver transplantation is a final treatment for decompensated liver disease. Aim Description of post-liver transplant histopathology. We enrolled 89 patients divided into two groups according to if they underwent on demand liver biopsy (n = 34; 38.2%) or not (n = 55; 61.8%). Albumin-bilirubin (ALBI) score and model for end-stage liver disease (MELD) assessed the degree of liver dysfunction. Results Patient underwent liver biopsy (LB) was 44.65 ± 8.46 years old, mainly males (88.2%) with average MELD of 8.74 ± 4.71. Most patients were positive pre-transplant for HCV (91.2%) and 29.4% had hepatocellular carcinoma on top of hepatitis C. Patients underwent LB had worse liver dysfunction by ALBI score (− 2.62 ± 0.6 vs. − 2.96 ± 0.5; p = 0.014) but comparable MELD. The time till first biopsy was 19.88 ± 11.22 (4-44) months. It was not different statistically with various histopathology (p > 0.05). Histopathology of first biopsy was viral chronic hepatitis (50%), acute rejection (20.6%), steatohepatitis (11.8%), chronic rejection (5.9%), chronic hepatitis (5.9%), biliary obstruction (2.9%), and cytomegalovirus hepatitis (2.9%). Most patients were F1 (38.2%) and A1 (35.3%). The immunosuppressive drug regimen had no impact on the histopathology (p > 0.05). Patients with hepatitis C pre-transplant had in a descending manner the following histological diagnosis (p = 0.001): viral chronic hepatitis 16 (51.6%), acute rejection 7 (22.6%), steatohepatitis 4 (12.9%), chronic rejection 2 (6.5%), biliary obstruction 1 (3.2%), and CMV hepatitis 1(3.2%). Some patients required on demand second (n = 9) and third biopsied (n = 5) that were the same as the first biopsy or completely different. Conclusion Liver biopsy is a useful tool for diagnosis of liver transplantation complications. |
| first_indexed | 2024-12-10T06:25:07Z |
| format | Article |
| id | doaj.art-ef18cb72fc4a4bac9235a82c32566977 |
| institution | Directory Open Access Journal |
| issn | 2090-6226 |
| language | English |
| last_indexed | 2024-12-10T06:25:07Z |
| publishDate | 2020-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj.art-ef18cb72fc4a4bac9235a82c325669772022-12-22T01:59:15ZengSpringerOpenEgyptian Liver Journal2090-62262020-05-0110111010.1186/s43066-020-00031-1Liver biopsy is still needed in liver transplantation recipients: a single center experienceEman Abdelsameea0Ayman Alsebaey1Nermine Ehsan2Ahmed Elrefaey3Khalid Aboelela4El-Sayed Ibrahim5Maha Elsabaawy6Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia UniversityDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia UniversityDepartment of Pathology, National Liver Institute, Menoufia UniversityDepartment of Pathology, National Liver Institute, Menoufia UniversityDepartment of Hepatobiliary Surgery, National Liver Institute, Menoufia UniversityDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia UniversityDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia UniversityAbstract Background Liver transplantation is a final treatment for decompensated liver disease. Aim Description of post-liver transplant histopathology. We enrolled 89 patients divided into two groups according to if they underwent on demand liver biopsy (n = 34; 38.2%) or not (n = 55; 61.8%). Albumin-bilirubin (ALBI) score and model for end-stage liver disease (MELD) assessed the degree of liver dysfunction. Results Patient underwent liver biopsy (LB) was 44.65 ± 8.46 years old, mainly males (88.2%) with average MELD of 8.74 ± 4.71. Most patients were positive pre-transplant for HCV (91.2%) and 29.4% had hepatocellular carcinoma on top of hepatitis C. Patients underwent LB had worse liver dysfunction by ALBI score (− 2.62 ± 0.6 vs. − 2.96 ± 0.5; p = 0.014) but comparable MELD. The time till first biopsy was 19.88 ± 11.22 (4-44) months. It was not different statistically with various histopathology (p > 0.05). Histopathology of first biopsy was viral chronic hepatitis (50%), acute rejection (20.6%), steatohepatitis (11.8%), chronic rejection (5.9%), chronic hepatitis (5.9%), biliary obstruction (2.9%), and cytomegalovirus hepatitis (2.9%). Most patients were F1 (38.2%) and A1 (35.3%). The immunosuppressive drug regimen had no impact on the histopathology (p > 0.05). Patients with hepatitis C pre-transplant had in a descending manner the following histological diagnosis (p = 0.001): viral chronic hepatitis 16 (51.6%), acute rejection 7 (22.6%), steatohepatitis 4 (12.9%), chronic rejection 2 (6.5%), biliary obstruction 1 (3.2%), and CMV hepatitis 1(3.2%). Some patients required on demand second (n = 9) and third biopsied (n = 5) that were the same as the first biopsy or completely different. Conclusion Liver biopsy is a useful tool for diagnosis of liver transplantation complications.http://link.springer.com/article/10.1186/s43066-020-00031-1LiverBiopsyLiver transplantationRejectionRecurrent post-transplant |
| spellingShingle | Eman Abdelsameea Ayman Alsebaey Nermine Ehsan Ahmed Elrefaey Khalid Aboelela El-Sayed Ibrahim Maha Elsabaawy Liver biopsy is still needed in liver transplantation recipients: a single center experience Egyptian Liver Journal Liver Biopsy Liver transplantation Rejection Recurrent post-transplant |
| title | Liver biopsy is still needed in liver transplantation recipients: a single center experience |
| title_full | Liver biopsy is still needed in liver transplantation recipients: a single center experience |
| title_fullStr | Liver biopsy is still needed in liver transplantation recipients: a single center experience |
| title_full_unstemmed | Liver biopsy is still needed in liver transplantation recipients: a single center experience |
| title_short | Liver biopsy is still needed in liver transplantation recipients: a single center experience |
| title_sort | liver biopsy is still needed in liver transplantation recipients a single center experience |
| topic | Liver Biopsy Liver transplantation Rejection Recurrent post-transplant |
| url | http://link.springer.com/article/10.1186/s43066-020-00031-1 |
| work_keys_str_mv | AT emanabdelsameea liverbiopsyisstillneededinlivertransplantationrecipientsasinglecenterexperience AT aymanalsebaey liverbiopsyisstillneededinlivertransplantationrecipientsasinglecenterexperience AT nermineehsan liverbiopsyisstillneededinlivertransplantationrecipientsasinglecenterexperience AT ahmedelrefaey liverbiopsyisstillneededinlivertransplantationrecipientsasinglecenterexperience AT khalidaboelela liverbiopsyisstillneededinlivertransplantationrecipientsasinglecenterexperience AT elsayedibrahim liverbiopsyisstillneededinlivertransplantationrecipientsasinglecenterexperience AT mahaelsabaawy liverbiopsyisstillneededinlivertransplantationrecipientsasinglecenterexperience |