An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT
Prostate cancer is still one of the main causes of cancer-related death in the male population, regardless of the advancements in the treatment scenario. The genetic knowledge on prostate cancer is widely increasing, allowing researchers to identify novel promising molecular targets and treatment ap...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/24/13519 |
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| author | Veronica Mollica Andrea Marchetti Matteo Rosellini Giacomo Nuvola Alessandro Rizzo Matteo Santoni Alessia Cimadamore Rodolfo Montironi Francesco Massari |
| author_facet | Veronica Mollica Andrea Marchetti Matteo Rosellini Giacomo Nuvola Alessandro Rizzo Matteo Santoni Alessia Cimadamore Rodolfo Montironi Francesco Massari |
| author_sort | Veronica Mollica |
| collection | DOAJ |
| description | Prostate cancer is still one of the main causes of cancer-related death in the male population, regardless of the advancements in the treatment scenario. The genetic knowledge on prostate cancer is widely increasing, allowing researchers to identify novel promising molecular targets and treatment approaches. Genomic profiling has evidenced that DNA damage repair genes’ alterations are quite frequent in metastatic, castration resistant prostate cancer and specific therapies can interfere with this pathway, showing promising activity in this setting. Microsatellite instability is gaining attention as it seems to represent a predictive factor of the response to immunotherapy. Furthermore, the PTEN-PI3K-AKT pathway is another possible treatment target being investigated. In this review, we explore the current knowledge on these frequent genomic alterations of metastatic prostate cancer, their possible therapeutic repercussions and the promising future treatments under evaluation. |
| first_indexed | 2024-03-10T03:56:05Z |
| format | Article |
| id | doaj.art-ef18f4accd4a4aad828e61a08253e58c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:56:05Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ef18f4accd4a4aad828e61a08253e58c2023-11-23T08:47:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122241351910.3390/ijms222413519An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKTVeronica Mollica0Andrea Marchetti1Matteo Rosellini2Giacomo Nuvola3Alessandro Rizzo4Matteo Santoni5Alessia Cimadamore6Rodolfo Montironi7Francesco Massari8Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni-15, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni-15, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni-15, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni-15, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni-15, 40138 Bologna, ItalyOncology Unit, Macerata Hospital, 62100 Macerata, ItalySection of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region, United Hospitals, 60126 Ancona, ItalyMolecular Medicine and Cell Therapy Foundation, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, 60100 Ancona, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni-15, 40138 Bologna, ItalyProstate cancer is still one of the main causes of cancer-related death in the male population, regardless of the advancements in the treatment scenario. The genetic knowledge on prostate cancer is widely increasing, allowing researchers to identify novel promising molecular targets and treatment approaches. Genomic profiling has evidenced that DNA damage repair genes’ alterations are quite frequent in metastatic, castration resistant prostate cancer and specific therapies can interfere with this pathway, showing promising activity in this setting. Microsatellite instability is gaining attention as it seems to represent a predictive factor of the response to immunotherapy. Furthermore, the PTEN-PI3K-AKT pathway is another possible treatment target being investigated. In this review, we explore the current knowledge on these frequent genomic alterations of metastatic prostate cancer, their possible therapeutic repercussions and the promising future treatments under evaluation.https://www.mdpi.com/1422-0067/22/24/13519AKTDDRimmunotherapymCRPCMSIPARP inhibitors |
| spellingShingle | Veronica Mollica Andrea Marchetti Matteo Rosellini Giacomo Nuvola Alessandro Rizzo Matteo Santoni Alessia Cimadamore Rodolfo Montironi Francesco Massari An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT International Journal of Molecular Sciences AKT DDR immunotherapy mCRPC MSI PARP inhibitors |
| title | An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT |
| title_full | An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT |
| title_fullStr | An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT |
| title_full_unstemmed | An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT |
| title_short | An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT |
| title_sort | insight on novel molecular pathways in metastatic prostate cancer a focus on ddr msi and akt |
| topic | AKT DDR immunotherapy mCRPC MSI PARP inhibitors |
| url | https://www.mdpi.com/1422-0067/22/24/13519 |
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