Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS
Chronic obstructive pulmonary disease (COPD) is an umbrella term used to define a collection of inflammatory lung diseases that cause airflow obstruction and severe damage to the lung parenchyma. This study investigated the robustness of image-registration-based local biomechanical properties of the...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Journal of Imaging |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2313-433X/8/11/309 |
| _version_ | 1827644399120547840 |
|---|---|
| author | Yue Pan Di Wang Muhammad F. A. Chaudhary Wei Shao Sarah E. Gerard Oguz C. Durumeric Surya P. Bhatt R. Graham Barr Eric A. Hoffman Joseph M. Reinhardt Gary E. Christensen |
| author_facet | Yue Pan Di Wang Muhammad F. A. Chaudhary Wei Shao Sarah E. Gerard Oguz C. Durumeric Surya P. Bhatt R. Graham Barr Eric A. Hoffman Joseph M. Reinhardt Gary E. Christensen |
| author_sort | Yue Pan |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is an umbrella term used to define a collection of inflammatory lung diseases that cause airflow obstruction and severe damage to the lung parenchyma. This study investigated the robustness of image-registration-based local biomechanical properties of the lung in individuals with COPD as a function of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage. Image registration was used to estimate the pointwise correspondences between the inspiration (total lung capacity) and expiration (residual volume) computed tomography (CT) images of the lung for each subject. In total, three biomechanical measures were computed from the correspondence map: the Jacobian determinant; the anisotropic deformation index (ADI); and the slab-rod index (SRI). CT scans from 245 subjects with varying GOLD stages were analyzed from the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS). Results show monotonic increasing or decreasing trends in the three biomechanical measures as a function of GOLD stage for the entire lung and on a lobe-by-lobe basis. Furthermore, these trends held across all five image registration algorithms. The consistency of the five image registration algorithms on a per individual basis is shown using Bland–Altman plots. |
| first_indexed | 2024-03-09T18:15:14Z |
| format | Article |
| id | doaj.art-ef1a2fe8217447ecaac7b005d064a681 |
| institution | Directory Open Access Journal |
| issn | 2313-433X |
| language | English |
| last_indexed | 2024-03-09T18:15:14Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Imaging |
| spelling | doaj.art-ef1a2fe8217447ecaac7b005d064a6812023-11-24T08:51:45ZengMDPI AGJournal of Imaging2313-433X2022-11-0181130910.3390/jimaging8110309Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICSYue Pan0Di Wang1Muhammad F. A. Chaudhary2Wei Shao3Sarah E. Gerard4Oguz C. Durumeric5Surya P. Bhatt6R. Graham Barr7Eric A. Hoffman8Joseph M. Reinhardt9Gary E. Christensen10Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, USADepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, USAThe Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USADepartment of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USAThe Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USADepartment of Mathematics, University of Iowa, Iowa City, IA 52242, USAUAB Lung Imaging Core, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USAThe Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USAThe Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USADepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, USAChronic obstructive pulmonary disease (COPD) is an umbrella term used to define a collection of inflammatory lung diseases that cause airflow obstruction and severe damage to the lung parenchyma. This study investigated the robustness of image-registration-based local biomechanical properties of the lung in individuals with COPD as a function of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage. Image registration was used to estimate the pointwise correspondences between the inspiration (total lung capacity) and expiration (residual volume) computed tomography (CT) images of the lung for each subject. In total, three biomechanical measures were computed from the correspondence map: the Jacobian determinant; the anisotropic deformation index (ADI); and the slab-rod index (SRI). CT scans from 245 subjects with varying GOLD stages were analyzed from the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS). Results show monotonic increasing or decreasing trends in the three biomechanical measures as a function of GOLD stage for the entire lung and on a lobe-by-lobe basis. Furthermore, these trends held across all five image registration algorithms. The consistency of the five image registration algorithms on a per individual basis is shown using Bland–Altman plots.https://www.mdpi.com/2313-433X/8/11/309image registrationlungbiomechanicsCOPDSPIROMICS |
| spellingShingle | Yue Pan Di Wang Muhammad F. A. Chaudhary Wei Shao Sarah E. Gerard Oguz C. Durumeric Surya P. Bhatt R. Graham Barr Eric A. Hoffman Joseph M. Reinhardt Gary E. Christensen Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS Journal of Imaging image registration lung biomechanics COPD SPIROMICS |
| title | Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS |
| title_full | Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS |
| title_fullStr | Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS |
| title_full_unstemmed | Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS |
| title_short | Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS |
| title_sort | robust measures of image registration derived lung biomechanics in spiromics |
| topic | image registration lung biomechanics COPD SPIROMICS |
| url | https://www.mdpi.com/2313-433X/8/11/309 |
| work_keys_str_mv | AT yuepan robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT diwang robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT muhammadfachaudhary robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT weishao robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT sarahegerard robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT oguzcdurumeric robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT suryapbhatt robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT rgrahambarr robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT ericahoffman robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT josephmreinhardt robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics AT garyechristensen robustmeasuresofimageregistrationderivedlungbiomechanicsinspiromics |