Protective effects of Cyclocarya paliurus on hyperuricemia and urate-induced inflammation
As a new and safe food resource, Cyclocarya paliurus (CP), rich in flavonoids, exhibits hypouricemic, anti-inflammatory and antioxidative properties. However, whether CP aqueous extract (CPA) still possesses the ameliorative effects on hyperuricemia (HUA) and urate-induced renal inflammation remains...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622002006 |
| _version_ | 1811242327520313344 |
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| author | Li-Hua Zhu Ying-Yin Xu Li-ping Zhu Xian Zheng Cui-Hua Jiang Jian-Jing Liu Jian Zhang Zhi-Qi Yin |
| author_facet | Li-Hua Zhu Ying-Yin Xu Li-ping Zhu Xian Zheng Cui-Hua Jiang Jian-Jing Liu Jian Zhang Zhi-Qi Yin |
| author_sort | Li-Hua Zhu |
| collection | DOAJ |
| description | As a new and safe food resource, Cyclocarya paliurus (CP), rich in flavonoids, exhibits hypouricemic, anti-inflammatory and antioxidative properties. However, whether CP aqueous extract (CPA) still possesses the ameliorative effects on hyperuricemia (HUA) and urate-induced renal inflammation remains vacant. In HUA mice, CPA could significantly reduce serum uric acid (UA), alleviate kidney damage and liver steatosis, inhibit xanthine oxidase (XOD) activity, ameliorate renal urate transporters and renal inflammation by inhibiting NLRP3 inflammasome and interleukin-1β (IL-1β). Moreover, the flavonoids quercetin-3-O-β-D-galactopyranoside, quercetin-3-O-β-D-glucopyranoside, and quercetin-3-O-α-L-rhamnopyranoside from CPA could significantly reduce IL-1β and interleukin-6 (IL-6) in MSU-challenged THP-1 cells. Noticeably, quercetin-3-O-β-D-galactopyranoside could inhibit the intracellular XOD activity, reduce intracellular ROS and the expression of pro-IL-1β, IL-1β, and NLRP3 inflammasome. Collectively, CPA shows appreciable therapeutic effects on HUA and evoked renal inflammation. Quercetin-3-O-β-D-galactopyranoside, quercetin-3-O-β-D-glucopyranoside, and quercetin-3-O-α-L-rhamnopyranoside might be the major active compounds of CPA, which obtain the favorable effects through blocking the activation of ROS/NLRP3/IL-1β pathway. |
| first_indexed | 2024-04-12T13:49:53Z |
| format | Article |
| id | doaj.art-ef1ac2aef800431ca589564b92e51a3c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-12T13:49:53Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ef1ac2aef800431ca589564b92e51a3c2022-12-22T03:30:34ZengElsevierJournal of Functional Foods1756-46462022-07-0194105130Protective effects of Cyclocarya paliurus on hyperuricemia and urate-induced inflammationLi-Hua Zhu0Ying-Yin Xu1Li-ping Zhu2Xian Zheng3Cui-Hua Jiang4Jian-Jing Liu5Jian Zhang6Zhi-Qi Yin7Department of Nephrology, Nanjing Lishui District Hospital of Traditional Chinese Pharmacy, Nanjing 211200, People’s Republic of China; Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, People’s Republic of China; Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People’s Republic of ChinaDepartment of Nephrology, Nanjing Lishui District Hospital of Traditional Chinese Pharmacy, Nanjing 211200, People’s Republic of ChinaDepartment of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People’s Republic of ChinaLaboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, People’s Republic of China; Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People’s Republic of ChinaLaboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, People’s Republic of ChinaLaboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, People’s Republic of ChinaDepartment of Nephrology, Nanjing Lishui District Hospital of Traditional Chinese Pharmacy, Nanjing 211200, People’s Republic of China; Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, People’s Republic of China; Corresponding authors.Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People’s Republic of China; Corresponding authors.As a new and safe food resource, Cyclocarya paliurus (CP), rich in flavonoids, exhibits hypouricemic, anti-inflammatory and antioxidative properties. However, whether CP aqueous extract (CPA) still possesses the ameliorative effects on hyperuricemia (HUA) and urate-induced renal inflammation remains vacant. In HUA mice, CPA could significantly reduce serum uric acid (UA), alleviate kidney damage and liver steatosis, inhibit xanthine oxidase (XOD) activity, ameliorate renal urate transporters and renal inflammation by inhibiting NLRP3 inflammasome and interleukin-1β (IL-1β). Moreover, the flavonoids quercetin-3-O-β-D-galactopyranoside, quercetin-3-O-β-D-glucopyranoside, and quercetin-3-O-α-L-rhamnopyranoside from CPA could significantly reduce IL-1β and interleukin-6 (IL-6) in MSU-challenged THP-1 cells. Noticeably, quercetin-3-O-β-D-galactopyranoside could inhibit the intracellular XOD activity, reduce intracellular ROS and the expression of pro-IL-1β, IL-1β, and NLRP3 inflammasome. Collectively, CPA shows appreciable therapeutic effects on HUA and evoked renal inflammation. Quercetin-3-O-β-D-galactopyranoside, quercetin-3-O-β-D-glucopyranoside, and quercetin-3-O-α-L-rhamnopyranoside might be the major active compounds of CPA, which obtain the favorable effects through blocking the activation of ROS/NLRP3/IL-1β pathway.http://www.sciencedirect.com/science/article/pii/S1756464622002006Cyclocarya paliurus aqueous extractFlavonoidsHyperuricemiaXODNLRP3 inflammation |
| spellingShingle | Li-Hua Zhu Ying-Yin Xu Li-ping Zhu Xian Zheng Cui-Hua Jiang Jian-Jing Liu Jian Zhang Zhi-Qi Yin Protective effects of Cyclocarya paliurus on hyperuricemia and urate-induced inflammation Journal of Functional Foods Cyclocarya paliurus aqueous extract Flavonoids Hyperuricemia XOD NLRP3 inflammation |
| title | Protective effects of Cyclocarya paliurus on hyperuricemia and urate-induced inflammation |
| title_full | Protective effects of Cyclocarya paliurus on hyperuricemia and urate-induced inflammation |
| title_fullStr | Protective effects of Cyclocarya paliurus on hyperuricemia and urate-induced inflammation |
| title_full_unstemmed | Protective effects of Cyclocarya paliurus on hyperuricemia and urate-induced inflammation |
| title_short | Protective effects of Cyclocarya paliurus on hyperuricemia and urate-induced inflammation |
| title_sort | protective effects of cyclocarya paliurus on hyperuricemia and urate induced inflammation |
| topic | Cyclocarya paliurus aqueous extract Flavonoids Hyperuricemia XOD NLRP3 inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622002006 |
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