The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study
High-flow nasal cannula (HFNC) and ventilator-delivered non-invasive mechanical ventilation (NIV) were used to treat acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia, especially in low- and middle-income countries (LMICs), due to lack of ventilators and manpower resources despite...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/9/1879 |
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| author | Sumalatha Arunachala Ashwaghosha Parthasarathi Chetak Kadabasal Basavaraj Sowmya Malamardi Shreya Chandran Hariharan Venkataraman Mohammed Kaleem Ullah Koustav Ganguly Swapna Upadhyay Padukudru Anand Mahesh |
| author_facet | Sumalatha Arunachala Ashwaghosha Parthasarathi Chetak Kadabasal Basavaraj Sowmya Malamardi Shreya Chandran Hariharan Venkataraman Mohammed Kaleem Ullah Koustav Ganguly Swapna Upadhyay Padukudru Anand Mahesh |
| author_sort | Sumalatha Arunachala |
| collection | DOAJ |
| description | High-flow nasal cannula (HFNC) and ventilator-delivered non-invasive mechanical ventilation (NIV) were used to treat acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia, especially in low- and middle-income countries (LMICs), due to lack of ventilators and manpower resources despite the paucity of data regarding their efficacy. This prospective study aimed to analyse the efficacy of HFNC versus NIV in the management of COVID-19 ARDS. A total of 88 RT-PCR-confirmed COVID-19 patients with moderate ARDS were recruited. Linear regression and generalized estimating equations (GEEs) were used for trends in vital parameters over time. A total of 37 patients were on HFNC, and 51 were on NIV. Patients in the HFNC group stayed slightly but not significantly longer in the ICU as compared to their NIV counterparts (HFNC vs. NIV: 8.00 (4.0–12.0) days vs. 7.00 (2.0–12.0) days; <i>p</i> = 0.055). Intubation rates, complications, and mortality were similar in both groups. The switch to HFNC from NIV was 5.8%, while 37.8% required a switch to NIV from HFNC. The resolution of respiratory alkalosis was better with NIV. We conclude that in patients with COVID-19 pneumonia with moderate ARDS, the duration of treatment in the ICU, intubation rate, and mortality did not differ significantly with the use of HFNC or NIV for respiratory support. |
| first_indexed | 2024-03-10T21:52:01Z |
| format | Article |
| id | doaj.art-ef1bafd4990f4adaa967339cf2e5447d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T21:52:01Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ef1bafd4990f4adaa967339cf2e5447d2023-11-19T13:23:01ZengMDPI AGViruses1999-49152023-09-01159187910.3390/v15091879The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective StudySumalatha Arunachala0Ashwaghosha Parthasarathi1Chetak Kadabasal Basavaraj2Sowmya Malamardi3Shreya Chandran4Hariharan Venkataraman5Mohammed Kaleem Ullah6Koustav Ganguly7Swapna Upadhyay8Padukudru Anand Mahesh9Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, IndiaAllergy, Asthma, and Chest Centre, Krishnamurthy Puram, Mysuru 570004, IndiaDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, IndiaDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, IndiaDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, IndiaDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, IndiaCentre for Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, IndiaUnit of Integrative Toxicology, Institute of Environmental Medicine (IMM), Karolinska Institute, 17177 Stockholm, SwedenUnit of Integrative Toxicology, Institute of Environmental Medicine (IMM), Karolinska Institute, 17177 Stockholm, SwedenDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, IndiaHigh-flow nasal cannula (HFNC) and ventilator-delivered non-invasive mechanical ventilation (NIV) were used to treat acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia, especially in low- and middle-income countries (LMICs), due to lack of ventilators and manpower resources despite the paucity of data regarding their efficacy. This prospective study aimed to analyse the efficacy of HFNC versus NIV in the management of COVID-19 ARDS. A total of 88 RT-PCR-confirmed COVID-19 patients with moderate ARDS were recruited. Linear regression and generalized estimating equations (GEEs) were used for trends in vital parameters over time. A total of 37 patients were on HFNC, and 51 were on NIV. Patients in the HFNC group stayed slightly but not significantly longer in the ICU as compared to their NIV counterparts (HFNC vs. NIV: 8.00 (4.0–12.0) days vs. 7.00 (2.0–12.0) days; <i>p</i> = 0.055). Intubation rates, complications, and mortality were similar in both groups. The switch to HFNC from NIV was 5.8%, while 37.8% required a switch to NIV from HFNC. The resolution of respiratory alkalosis was better with NIV. We conclude that in patients with COVID-19 pneumonia with moderate ARDS, the duration of treatment in the ICU, intubation rate, and mortality did not differ significantly with the use of HFNC or NIV for respiratory support.https://www.mdpi.com/1999-4915/15/9/1879COVID-19pneumoniaARDShigh-flow nasal cannulanon-invasive mechanical ventilation |
| spellingShingle | Sumalatha Arunachala Ashwaghosha Parthasarathi Chetak Kadabasal Basavaraj Sowmya Malamardi Shreya Chandran Hariharan Venkataraman Mohammed Kaleem Ullah Koustav Ganguly Swapna Upadhyay Padukudru Anand Mahesh The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study Viruses COVID-19 pneumonia ARDS high-flow nasal cannula non-invasive mechanical ventilation |
| title | The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study |
| title_full | The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study |
| title_fullStr | The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study |
| title_full_unstemmed | The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study |
| title_short | The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study |
| title_sort | use of high flow nasal cannula and non invasive mechanical ventilation in the management of covid 19 patients a prospective study |
| topic | COVID-19 pneumonia ARDS high-flow nasal cannula non-invasive mechanical ventilation |
| url | https://www.mdpi.com/1999-4915/15/9/1879 |
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