IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging

IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging

CD4+Foxp3+Tregs maintain immune homeostasis, but distinct mechanisms underlying their functional heterogeneity during infections are driven by specific cytokine milieu. Here we show that MyD88 deletion in Foxp3+ cells altered their function and resulted in increased fungal burden and immunopathology...

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Bibliographic Details
Main Authors: Natarajan Bhaskaran, Fady Faddoul, Andre Paes da Silva, Sangeetha Jayaraman, Elizabeth Schneider, Prerna Mamileti, Aaron Weinberg, Pushpa Pandiyan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
Treg
Foxp3
Treg17
IL-1β
Candida
fungal infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.595936/full

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