Clinical and Haematological Picture of Multi-Transfused Thalassaemia Major Patients at a Center in Pakistan
Objective: To describe the clinical and haematological picture of multiply transfused patients of thalassaemia major at a treatment center in Pakistan. Study Design: Descriptive cross-sectional. Place and Duration of Study: The study was conducted at Thalassaemia Treatment Centre Rawalpindi. The stu...
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| Format: | Article |
| Language: | English |
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Riphah International University, Islamabad
2018-06-01
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| Series: | Journal of Islamic International Medical College |
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| Online Access: | https://journals.riphah.edu.pk/index.php/jiimc/article/view/1029 |
| _version_ | 1811237580363005952 |
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| author | Suhaib Ahmed , Zohra Jabeen Wazir , Ishrat Abdul Qayyum |
| author_facet | Suhaib Ahmed , Zohra Jabeen Wazir , Ishrat Abdul Qayyum |
| author_sort | Suhaib Ahmed , Zohra Jabeen Wazir , Ishrat Abdul Qayyum |
| collection | DOAJ |
| description | Objective: To describe the clinical and haematological picture of multiply transfused patients of thalassaemia major at a treatment center in Pakistan.
Study Design: Descriptive cross-sectional.
Place and Duration of Study: The study was conducted at Thalassaemia Treatment Centre Rawalpindi. The study was done between Jan 1994 and May 2017.
Materials and Methods: A total of 383 patients of thalassaemia major (TM) on regular blood transfusions were examined for various clinical and haematological parameters. In addition case records of 101 patients of TM who died during treatment were also studied.
Results: In the 383 patients on treatment 328 (86%) were born to consanguineous parents, 246 (64%) were from lower socio-economic group, 85 (22%) had one or more affected siblings, 145 (38%) had hepatomegaly, 191 (50%) had splenomegaly, 42 (11%) had undergone splenectomy and 187 (49%) had never received iron chelation therapy. Height and weight in the 383 patients on treatment showed marked stunting. Median age of the 383 patients on treatment was 104 months as compared to 119 months in the deceased group of patients (p=0.0263). Pre-transfusion Hb in the alive patients (7.1 g/dL) was higher than in the deceased patients (6.4 g/dL) (p=0.0142). Ferritin level in the patients on treatment (3698 μg/L) was lower than in the deceasedpatients (4616 μg/L) (p=0.0069). In the 383 patients on treatment 141 (36.8%) were HCV positive.
Conclusion: Majority of the patients at a thalassaemia treatment center are chronically under-transfused and
have moderate to severe growth retardation. They get inadequate iron chelation resulting in high mortality
before tenth year of life. |
| first_indexed | 2024-04-12T12:25:59Z |
| format | Article |
| id | doaj.art-ef227aee0406425f93bc421fc4be662b |
| institution | Directory Open Access Journal |
| issn | 1815-4018 2410-5422 |
| language | English |
| last_indexed | 2024-04-12T12:25:59Z |
| publishDate | 2018-06-01 |
| publisher | Riphah International University, Islamabad |
| record_format | Article |
| series | Journal of Islamic International Medical College |
| spelling | doaj.art-ef227aee0406425f93bc421fc4be662b2022-12-22T03:33:09ZengRiphah International University, IslamabadJournal of Islamic International Medical College1815-40182410-54222018-06-0113252561425Clinical and Haematological Picture of Multi-Transfused Thalassaemia Major Patients at a Center in PakistanSuhaib Ahmed , Zohra Jabeen Wazir , Ishrat Abdul QayyumObjective: To describe the clinical and haematological picture of multiply transfused patients of thalassaemia major at a treatment center in Pakistan. Study Design: Descriptive cross-sectional. Place and Duration of Study: The study was conducted at Thalassaemia Treatment Centre Rawalpindi. The study was done between Jan 1994 and May 2017. Materials and Methods: A total of 383 patients of thalassaemia major (TM) on regular blood transfusions were examined for various clinical and haematological parameters. In addition case records of 101 patients of TM who died during treatment were also studied. Results: In the 383 patients on treatment 328 (86%) were born to consanguineous parents, 246 (64%) were from lower socio-economic group, 85 (22%) had one or more affected siblings, 145 (38%) had hepatomegaly, 191 (50%) had splenomegaly, 42 (11%) had undergone splenectomy and 187 (49%) had never received iron chelation therapy. Height and weight in the 383 patients on treatment showed marked stunting. Median age of the 383 patients on treatment was 104 months as compared to 119 months in the deceased group of patients (p=0.0263). Pre-transfusion Hb in the alive patients (7.1 g/dL) was higher than in the deceased patients (6.4 g/dL) (p=0.0142). Ferritin level in the patients on treatment (3698 μg/L) was lower than in the deceasedpatients (4616 μg/L) (p=0.0069). In the 383 patients on treatment 141 (36.8%) were HCV positive. Conclusion: Majority of the patients at a thalassaemia treatment center are chronically under-transfused and have moderate to severe growth retardation. They get inadequate iron chelation resulting in high mortality before tenth year of life.https://journals.riphah.edu.pk/index.php/jiimc/article/view/1029blood transfusion, complications, pakistan, survival, thalassemia. |
| spellingShingle | Suhaib Ahmed , Zohra Jabeen Wazir , Ishrat Abdul Qayyum Clinical and Haematological Picture of Multi-Transfused Thalassaemia Major Patients at a Center in Pakistan Journal of Islamic International Medical College blood transfusion, complications, pakistan, survival, thalassemia. |
| title | Clinical and Haematological Picture of Multi-Transfused Thalassaemia Major Patients at a Center in Pakistan |
| title_full | Clinical and Haematological Picture of Multi-Transfused Thalassaemia Major Patients at a Center in Pakistan |
| title_fullStr | Clinical and Haematological Picture of Multi-Transfused Thalassaemia Major Patients at a Center in Pakistan |
| title_full_unstemmed | Clinical and Haematological Picture of Multi-Transfused Thalassaemia Major Patients at a Center in Pakistan |
| title_short | Clinical and Haematological Picture of Multi-Transfused Thalassaemia Major Patients at a Center in Pakistan |
| title_sort | clinical and haematological picture of multi transfused thalassaemia major patients at a center in pakistan |
| topic | blood transfusion, complications, pakistan, survival, thalassemia. |
| url | https://journals.riphah.edu.pk/index.php/jiimc/article/view/1029 |
| work_keys_str_mv | AT suhaibahmedzohrajabeenwazirishratabdulqayyum clinicalandhaematologicalpictureofmultitransfusedthalassaemiamajorpatientsatacenterinpakistan |