Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems – a real-world analysis at a Swiss tertiary centre
AIMS OF THE STUDY: To assess glucose levels in adults with diabetes at a Swiss tertiary hospital when transitioning from insulin delivery with a sensor-augmented pump with (predictive) low-glucose suspend ([P]LGS) to a hybrid-closed loop (HCL) and from a HCL to an advanced hybrid-closed loop (AHCL)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2023-12-01
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| Series: | Swiss Medical Weekly |
| Online Access: | https://smw.ch/index.php/smw/article/view/3501 |
| _version_ | 1826992886415097856 |
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| author | Vera Lehmann Franco Noti Markus Laimer Christoph Stettler Thomas Züger |
| author_facet | Vera Lehmann Franco Noti Markus Laimer Christoph Stettler Thomas Züger |
| author_sort | Vera Lehmann |
| collection | DOAJ |
| description |
AIMS OF THE STUDY: To assess glucose levels in adults with diabetes at a Swiss tertiary hospital when transitioning from insulin delivery with a sensor-augmented pump with (predictive) low-glucose suspend ([P]LGS) to a hybrid-closed loop (HCL) and from a HCL to an advanced hybrid-closed loop (AHCL).
METHODS: Continuous glucose monitoring data for 44 adults with type 1 diabetes transitioning from (P)LGS to hybrid-closed loop and from hybrid-closed loop to advanced hybrid-closed loop were analysed, including the percentage of time spent within, below, and above glucose ranges. In addition, a subgroup analysis (n = 14) of individuals undergoing both transitions was performed.
RESULTS: The transition from a (P)LGS to a hybrid-closed loop was associated with increased time in range (6.6% [2.6%–12.7%], p <0.001) and decreased time above range (5.6% [2.3%–12.7%], p <0.001). The transition from a hybrid-closed loop to an advanced hybrid-closed loop was associated with increased time in range (1.6% [−0.5%–4.5%], p = 0.046) and decreased time above range (1.5% [–1.8%–5.6%], p = 0.050). Both transitions did not change the time below range. In the subgroup analysis ([P]LGS → HCL → AHCL), the time in range increased from 69.4% (50.3%–79.2%) to 76.5% (65.3%–81.3%) and 78.7% (69.7%–85.8%), respectively (p <0.001).
CONCLUSIONS: Glucose levels significantly improved when transitioning from a (P)LGS to a hybrid-closed loop. Glucose levels improved further when switching from a hybrid-closed loop to an advanced hybrid-closed loop. However, the added benefit of an advanced hybrid-closed loop was comparably smaller. This pattern was also reflected in the subgroup analysis.
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| format | Article |
| id | doaj.art-ef251455e290483c98879d0a4ffed537 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2025-02-18T08:57:21Z |
| publishDate | 2023-12-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-ef251455e290483c98879d0a4ffed5372024-11-02T23:54:50ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972023-12-011531210.57187/s.3501Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems – a real-world analysis at a Swiss tertiary centreVera LehmannFranco NotiMarkus LaimerChristoph StettlerThomas Züger AIMS OF THE STUDY: To assess glucose levels in adults with diabetes at a Swiss tertiary hospital when transitioning from insulin delivery with a sensor-augmented pump with (predictive) low-glucose suspend ([P]LGS) to a hybrid-closed loop (HCL) and from a HCL to an advanced hybrid-closed loop (AHCL). METHODS: Continuous glucose monitoring data for 44 adults with type 1 diabetes transitioning from (P)LGS to hybrid-closed loop and from hybrid-closed loop to advanced hybrid-closed loop were analysed, including the percentage of time spent within, below, and above glucose ranges. In addition, a subgroup analysis (n = 14) of individuals undergoing both transitions was performed. RESULTS: The transition from a (P)LGS to a hybrid-closed loop was associated with increased time in range (6.6% [2.6%–12.7%], p <0.001) and decreased time above range (5.6% [2.3%–12.7%], p <0.001). The transition from a hybrid-closed loop to an advanced hybrid-closed loop was associated with increased time in range (1.6% [−0.5%–4.5%], p = 0.046) and decreased time above range (1.5% [–1.8%–5.6%], p = 0.050). Both transitions did not change the time below range. In the subgroup analysis ([P]LGS → HCL → AHCL), the time in range increased from 69.4% (50.3%–79.2%) to 76.5% (65.3%–81.3%) and 78.7% (69.7%–85.8%), respectively (p <0.001). CONCLUSIONS: Glucose levels significantly improved when transitioning from a (P)LGS to a hybrid-closed loop. Glucose levels improved further when switching from a hybrid-closed loop to an advanced hybrid-closed loop. However, the added benefit of an advanced hybrid-closed loop was comparably smaller. This pattern was also reflected in the subgroup analysis. https://smw.ch/index.php/smw/article/view/3501 |
| spellingShingle | Vera Lehmann Franco Noti Markus Laimer Christoph Stettler Thomas Züger Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems – a real-world analysis at a Swiss tertiary centre Swiss Medical Weekly |
| title | Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems – a real-world analysis at a Swiss tertiary centre |
| title_full | Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems – a real-world analysis at a Swiss tertiary centre |
| title_fullStr | Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems – a real-world analysis at a Swiss tertiary centre |
| title_full_unstemmed | Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems – a real-world analysis at a Swiss tertiary centre |
| title_short | Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems – a real-world analysis at a Swiss tertiary centre |
| title_sort | glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems a real world analysis at a swiss tertiary centre |
| url | https://smw.ch/index.php/smw/article/view/3501 |
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