Prognostic Value of Lymphocyte-to-Monocyte Ratio (LMR) in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis
The objective of this study is to evaluate the prognostic value of lymphocyte-to-monocyte ratio (LMR) in patients with prostate cancer (PCa) by a method of meta-analysis. China National Knowledge Infrastructure (CNKI), Wanfang Data, PubMed, Web of Science, Cochrane Library, and Embase were searched...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-03-01
|
| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883241234747 |
| _version_ | 1797248783656943616 |
|---|---|
| author | Qin Xiang Yueguang Liu Junwen Xiao Longhua Ou Jianhui Du |
| author_facet | Qin Xiang Yueguang Liu Junwen Xiao Longhua Ou Jianhui Du |
| author_sort | Qin Xiang |
| collection | DOAJ |
| description | The objective of this study is to evaluate the prognostic value of lymphocyte-to-monocyte ratio (LMR) in patients with prostate cancer (PCa) by a method of meta-analysis. China National Knowledge Infrastructure (CNKI), Wanfang Data, PubMed, Web of Science, Cochrane Library, and Embase were searched to collect relevant literature until March 2023. The Newcastle-Ottawa Scale was used to assess the bias risk of the literature included. Hazard ratios (HRs) and 95% confidence intervals (CIs) were used to evaluate the prognostic value of LMR in PCa. Stata 15.0 statistical software was used for data analysis. A total of six published articles were included in this meta-analysis, containing 1,104 patients with PCa. The results of the meta-analysis indicated better overall survival (OS; HR = 1.73, 95% CI: 1.73, p = .001) and progression-free survival (PFS; HR = 2.63, 95% CI: 1.58~4.38, p < .001) in patients with PCa with low LMR compared with high LMR. In conclusion, compared with low LMR, PCa patients with high LMR have a better prognosis. LMR is an independent risk factor affecting the long-term prognosis of patients with PCa. The detection of LMR before treatment is of certain significance in judging the clinical prognosis of patients with PCa. |
| first_indexed | 2024-04-24T20:20:05Z |
| format | Article |
| id | doaj.art-ef268dcb5f364fe8ba13ae17b048df24 |
| institution | Directory Open Access Journal |
| issn | 1557-9891 |
| language | English |
| last_indexed | 2024-04-24T20:20:05Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-ef268dcb5f364fe8ba13ae17b048df242024-03-22T10:03:30ZengSAGE PublishingAmerican Journal of Men's Health1557-98912024-03-011810.1177/15579883241234747Prognostic Value of Lymphocyte-to-Monocyte Ratio (LMR) in Patients With Prostate Cancer: A Systematic Review and Meta-AnalysisQin Xiang0Yueguang Liu1Junwen Xiao2Longhua Ou3Jianhui Du4Department of Urology, Shenzhen Bao’an District Songgang People’s Hospital, Shenzhen, ChinaDepartment of Urology, Shenzhen Bao’an District Songgang People’s Hospital, Shenzhen, ChinaDepartment of Urology, Shenzhen Bao’an District Songgang People’s Hospital, Shenzhen, ChinaDepartment of Urology, Shenzhen Bao’an District Songgang People’s Hospital, Shenzhen, ChinaDepartment of Urology, People’s Hospital of Guang’an, Guang’an, ChinaThe objective of this study is to evaluate the prognostic value of lymphocyte-to-monocyte ratio (LMR) in patients with prostate cancer (PCa) by a method of meta-analysis. China National Knowledge Infrastructure (CNKI), Wanfang Data, PubMed, Web of Science, Cochrane Library, and Embase were searched to collect relevant literature until March 2023. The Newcastle-Ottawa Scale was used to assess the bias risk of the literature included. Hazard ratios (HRs) and 95% confidence intervals (CIs) were used to evaluate the prognostic value of LMR in PCa. Stata 15.0 statistical software was used for data analysis. A total of six published articles were included in this meta-analysis, containing 1,104 patients with PCa. The results of the meta-analysis indicated better overall survival (OS; HR = 1.73, 95% CI: 1.73, p = .001) and progression-free survival (PFS; HR = 2.63, 95% CI: 1.58~4.38, p < .001) in patients with PCa with low LMR compared with high LMR. In conclusion, compared with low LMR, PCa patients with high LMR have a better prognosis. LMR is an independent risk factor affecting the long-term prognosis of patients with PCa. The detection of LMR before treatment is of certain significance in judging the clinical prognosis of patients with PCa.https://doi.org/10.1177/15579883241234747 |
| spellingShingle | Qin Xiang Yueguang Liu Junwen Xiao Longhua Ou Jianhui Du Prognostic Value of Lymphocyte-to-Monocyte Ratio (LMR) in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis American Journal of Men's Health |
| title | Prognostic Value of Lymphocyte-to-Monocyte Ratio (LMR) in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis |
| title_full | Prognostic Value of Lymphocyte-to-Monocyte Ratio (LMR) in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis |
| title_fullStr | Prognostic Value of Lymphocyte-to-Monocyte Ratio (LMR) in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prognostic Value of Lymphocyte-to-Monocyte Ratio (LMR) in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis |
| title_short | Prognostic Value of Lymphocyte-to-Monocyte Ratio (LMR) in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis |
| title_sort | prognostic value of lymphocyte to monocyte ratio lmr in patients with prostate cancer a systematic review and meta analysis |
| url | https://doi.org/10.1177/15579883241234747 |
| work_keys_str_mv | AT qinxiang prognosticvalueoflymphocytetomonocyteratiolmrinpatientswithprostatecancerasystematicreviewandmetaanalysis AT yueguangliu prognosticvalueoflymphocytetomonocyteratiolmrinpatientswithprostatecancerasystematicreviewandmetaanalysis AT junwenxiao prognosticvalueoflymphocytetomonocyteratiolmrinpatientswithprostatecancerasystematicreviewandmetaanalysis AT longhuaou prognosticvalueoflymphocytetomonocyteratiolmrinpatientswithprostatecancerasystematicreviewandmetaanalysis AT jianhuidu prognosticvalueoflymphocytetomonocyteratiolmrinpatientswithprostatecancerasystematicreviewandmetaanalysis |