Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study
Posterior fossa tumours (PFTs) in infants are very rare, and information on these tumours is scarce in the literature. This retrospective study reports their pathological characteristics and describes surgical aspects and treatment outcomes. A two-centre cohort of infants with PFTs treated from 2007...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/3/635 |
| _version_ | 1797472037077254144 |
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| author | Stefania Picariello Pietro Spennato Jonathan Roth Nir Shimony Alessandra Marini Lucia De Martino Giancarlo Nicosia Giuseppe Mirone Maria Serena De Santi Fabio Savoia Maria Elena Errico Lucia Quaglietta Shlomi Costantini Giuseppe Cinalli |
| author_facet | Stefania Picariello Pietro Spennato Jonathan Roth Nir Shimony Alessandra Marini Lucia De Martino Giancarlo Nicosia Giuseppe Mirone Maria Serena De Santi Fabio Savoia Maria Elena Errico Lucia Quaglietta Shlomi Costantini Giuseppe Cinalli |
| author_sort | Stefania Picariello |
| collection | DOAJ |
| description | Posterior fossa tumours (PFTs) in infants are very rare, and information on these tumours is scarce in the literature. This retrospective study reports their pathological characteristics and describes surgical aspects and treatment outcomes. A two-centre cohort of infants with PFTs treated from 2007 to 2018 was retrospectively reviewed. Patient characteristics, clinical, and treatment data were reviewed. Survival curves for progression-free survival (PFS) and overall survival (OS) were generated. Thirty-three infants were retrieved. There were 11 low grade and 22 high-grade tumours. The most common presenting symptom was intracranial hypertension. Fifteen children out of thirty-three progressed. Five-year PFS was significantly lower in children with high-grade tumours (38.3%) than those with low-grade tumours (69.3%), <i>p</i> = 0.030. High-grade pathology was the only predictor of progression (HR 3.7, 95% CI 1.1–13.31), <i>p</i> = 0.045. Fourteen children with high-grade tumours died, with a 5-year OS of 55.25%. PFTs in children below one year of age still represent a unique challenge. Infants with high-grade tumours display the worst outcomes and the lowest survival, indicating that more effective strategies are needed. |
| first_indexed | 2024-03-09T19:57:30Z |
| format | Article |
| id | doaj.art-ef27d2c720ae4e87b5af04cad914fbd7 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:57:30Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-ef27d2c720ae4e87b5af04cad914fbd72023-11-24T00:55:03ZengMDPI AGDiagnostics2075-44182022-03-0112363510.3390/diagnostics12030635Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective StudyStefania Picariello0Pietro Spennato1Jonathan Roth2Nir Shimony3Alessandra Marini4Lucia De Martino5Giancarlo Nicosia6Giuseppe Mirone7Maria Serena De Santi8Fabio Savoia9Maria Elena Errico10Lucia Quaglietta11Shlomi Costantini12Giuseppe Cinalli13Neuro-Oncology Unit, Department of Paediatric Oncology, Santobono-Pausilipon Children’s Hospital, Via Mario Fiore 6, 80129 Naples, ItalyDivision of Neurosurgery, Department of Neurosciences, Santobono-Pausilipon Children’s Hospital, Via Mario Fiore 6, 80129 Naples, ItalyDepartments of Pediatric Neurosurgery, Dana Children’s Hospital, Tel Aviv Medical Center, Tel Aviv University, 6 Weizmann St., Tel Aviv 6423906, IsraelDepartments of Pediatric Neurosurgery, Dana Children’s Hospital, Tel Aviv Medical Center, Tel Aviv University, 6 Weizmann St., Tel Aviv 6423906, IsraelDepartment of Neurosurgery, Ospedale Santa Maria della Misericordia di Perugia, Piazzale Giorgio Menghini 3, 06129 Perugia, ItalyNeuro-Oncology Unit, Department of Paediatric Oncology, Santobono-Pausilipon Children’s Hospital, Via Mario Fiore 6, 80129 Naples, ItalyNeurosurgery Unit, San Pio Hospital, Via Pacevecchia 53, 82100 Benevento, ItalyDivision of Neurosurgery, Department of Neurosciences, Santobono-Pausilipon Children’s Hospital, Via Mario Fiore 6, 80129 Naples, ItalyDivision of Neurosurgery, Department of Neurosciences, Santobono-Pausilipon Children’s Hospital, Via Mario Fiore 6, 80129 Naples, ItalyChildhood Cancer Registry of Campania, Santobono-Pausilipon Children’s Hospital, Via della Croce Rossa 8, 80129 Naples, ItalyDepartment of Pathology, Santobono-Pausilipon Children’s Hospital, Via Posillipo 226, 80123 Naples, ItalyNeuro-Oncology Unit, Department of Paediatric Oncology, Santobono-Pausilipon Children’s Hospital, Via Mario Fiore 6, 80129 Naples, ItalyDepartments of Pediatric Neurosurgery, Dana Children’s Hospital, Tel Aviv Medical Center, Tel Aviv University, 6 Weizmann St., Tel Aviv 6423906, IsraelDivision of Neurosurgery, Department of Neurosciences, Santobono-Pausilipon Children’s Hospital, Via Mario Fiore 6, 80129 Naples, ItalyPosterior fossa tumours (PFTs) in infants are very rare, and information on these tumours is scarce in the literature. This retrospective study reports their pathological characteristics and describes surgical aspects and treatment outcomes. A two-centre cohort of infants with PFTs treated from 2007 to 2018 was retrospectively reviewed. Patient characteristics, clinical, and treatment data were reviewed. Survival curves for progression-free survival (PFS) and overall survival (OS) were generated. Thirty-three infants were retrieved. There were 11 low grade and 22 high-grade tumours. The most common presenting symptom was intracranial hypertension. Fifteen children out of thirty-three progressed. Five-year PFS was significantly lower in children with high-grade tumours (38.3%) than those with low-grade tumours (69.3%), <i>p</i> = 0.030. High-grade pathology was the only predictor of progression (HR 3.7, 95% CI 1.1–13.31), <i>p</i> = 0.045. Fourteen children with high-grade tumours died, with a 5-year OS of 55.25%. PFTs in children below one year of age still represent a unique challenge. Infants with high-grade tumours display the worst outcomes and the lowest survival, indicating that more effective strategies are needed.https://www.mdpi.com/2075-4418/12/3/635infratentorial tumoursposterior fossa tumoursinfantsAtypical Teratoid/Rhabdoid Tumourmedulloblastomaastrocytoma |
| spellingShingle | Stefania Picariello Pietro Spennato Jonathan Roth Nir Shimony Alessandra Marini Lucia De Martino Giancarlo Nicosia Giuseppe Mirone Maria Serena De Santi Fabio Savoia Maria Elena Errico Lucia Quaglietta Shlomi Costantini Giuseppe Cinalli Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study Diagnostics infratentorial tumours posterior fossa tumours infants Atypical Teratoid/Rhabdoid Tumour medulloblastoma astrocytoma |
| title | Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study |
| title_full | Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study |
| title_fullStr | Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study |
| title_full_unstemmed | Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study |
| title_short | Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study |
| title_sort | posterior fossa tumours in the first year of life a two centre retrospective study |
| topic | infratentorial tumours posterior fossa tumours infants Atypical Teratoid/Rhabdoid Tumour medulloblastoma astrocytoma |
| url | https://www.mdpi.com/2075-4418/12/3/635 |
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