Ethnobotanical, Phytochemical, Toxicological, and Pharmacological Properties of <i>Ziziphus lotus</i> (L.) Lam.: A Comprehensive Review
<i>Ziziphus lotus</i> (L.) Lam. (Rhamnaceae) is a plant species found across the Mediterranean area. This comprehensive overview aims to summarize the botanical description and ethnobotanical uses of <i>Z. lotus</i> and its phytochemical compounds derived with recent updates...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/4/575 |
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| author | Noureddine Bencheikh Fatima Zahrae Radi Jamila Fakchich Amine Elbouzidi Sabir Ouahhoud Mohammed Ouasti Mohamed Bouhrim Imane Ouasti Christophe Hano Mostafa Elachouri |
| author_facet | Noureddine Bencheikh Fatima Zahrae Radi Jamila Fakchich Amine Elbouzidi Sabir Ouahhoud Mohammed Ouasti Mohamed Bouhrim Imane Ouasti Christophe Hano Mostafa Elachouri |
| author_sort | Noureddine Bencheikh |
| collection | DOAJ |
| description | <i>Ziziphus lotus</i> (L.) Lam. (Rhamnaceae) is a plant species found across the Mediterranean area. This comprehensive overview aims to summarize the botanical description and ethnobotanical uses of <i>Z. lotus</i> and its phytochemical compounds derived with recent updates on its pharmacological and toxicological properties. The data were collected from electronic databases including the Web of Science, PubMed, ScienceDirect, Scopus, SpringerLink, and Google Scholars. It can be seen from the literature that <i>Z. lotus</i> is traditionally used to treat and prevent several diseases including diabetes, digestive problems, urinary tract problems, infectious diseases, cardiovascular disorders, neurological diseases, and dermal problems. The extracts of <i>Z. lotus</i> demonstrated several pharmacological properties in vitro and in vivo such as antidiabetic, anticancer, anti-oxidant, antimicrobials, anti-inflammatory, immunomodulatory, analgesic, anti-proliferative, anti-spasmodic, hepatoprotective, and nephroprotective effects. The phytochemical characterization of <i>Z. lotus</i> extracts revealed the presence of over 181 bioactive compounds including terpenoids, polyphenols, flavonoids, alkaloids, and fatty acids. Toxicity studies on <i>Z. lotus</i> showed that extracts from this plant are safe and free from toxicity. Thus, further research is needed to establish a possible relationship between traditional uses, plant chemistry, and pharmacological properties. Furthermore, <i>Z. lotus</i> is quite promising as a medicinal agent, so further clinical trials should be conducted to prove its efficacy. |
| first_indexed | 2024-03-11T04:39:52Z |
| format | Article |
| id | doaj.art-ef299d8ae9464b02a172fb4489cfa8b0 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T04:39:52Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-ef299d8ae9464b02a172fb4489cfa8b02023-11-17T20:50:52ZengMDPI AGPharmaceuticals1424-82472023-04-0116457510.3390/ph16040575Ethnobotanical, Phytochemical, Toxicological, and Pharmacological Properties of <i>Ziziphus lotus</i> (L.) Lam.: A Comprehensive ReviewNoureddine Bencheikh0Fatima Zahrae Radi1Jamila Fakchich2Amine Elbouzidi3Sabir Ouahhoud4Mohammed Ouasti5Mohamed Bouhrim6Imane Ouasti7Christophe Hano8Mostafa Elachouri9Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, MoroccoResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismail University of Meknes, B.P. 11201, Zitoune, Meknes 50070, MoroccoLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, MoroccoLaboratoire d’Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda 60000, MoroccoLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, MoroccoLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, MoroccoLaboratory of Biological Engineering, Team of Functional and Pathological Biology, Faculty of Sciences and Technology Beni Mellal, University Sultan Moulay Slimane, Beni-Mellal 23000, MoroccoLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, MoroccoLaboratoire de Biologie des Ligneux et des Grandes Cultures, INRAE USC1328, Campus Eure et Loir, Orleans University, 28000 Chartres, FranceLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, Morocco<i>Ziziphus lotus</i> (L.) Lam. (Rhamnaceae) is a plant species found across the Mediterranean area. This comprehensive overview aims to summarize the botanical description and ethnobotanical uses of <i>Z. lotus</i> and its phytochemical compounds derived with recent updates on its pharmacological and toxicological properties. The data were collected from electronic databases including the Web of Science, PubMed, ScienceDirect, Scopus, SpringerLink, and Google Scholars. It can be seen from the literature that <i>Z. lotus</i> is traditionally used to treat and prevent several diseases including diabetes, digestive problems, urinary tract problems, infectious diseases, cardiovascular disorders, neurological diseases, and dermal problems. The extracts of <i>Z. lotus</i> demonstrated several pharmacological properties in vitro and in vivo such as antidiabetic, anticancer, anti-oxidant, antimicrobials, anti-inflammatory, immunomodulatory, analgesic, anti-proliferative, anti-spasmodic, hepatoprotective, and nephroprotective effects. The phytochemical characterization of <i>Z. lotus</i> extracts revealed the presence of over 181 bioactive compounds including terpenoids, polyphenols, flavonoids, alkaloids, and fatty acids. Toxicity studies on <i>Z. lotus</i> showed that extracts from this plant are safe and free from toxicity. Thus, further research is needed to establish a possible relationship between traditional uses, plant chemistry, and pharmacological properties. Furthermore, <i>Z. lotus</i> is quite promising as a medicinal agent, so further clinical trials should be conducted to prove its efficacy.https://www.mdpi.com/1424-8247/16/4/575<i>Ziziphus lotus</i> (L.) Lam.ethnobotanytraditional medicinephytochemicaltoxicologicalpharmacological activities |
| spellingShingle | Noureddine Bencheikh Fatima Zahrae Radi Jamila Fakchich Amine Elbouzidi Sabir Ouahhoud Mohammed Ouasti Mohamed Bouhrim Imane Ouasti Christophe Hano Mostafa Elachouri Ethnobotanical, Phytochemical, Toxicological, and Pharmacological Properties of <i>Ziziphus lotus</i> (L.) Lam.: A Comprehensive Review Pharmaceuticals <i>Ziziphus lotus</i> (L.) Lam. ethnobotany traditional medicine phytochemical toxicological pharmacological activities |
| title | Ethnobotanical, Phytochemical, Toxicological, and Pharmacological Properties of <i>Ziziphus lotus</i> (L.) Lam.: A Comprehensive Review |
| title_full | Ethnobotanical, Phytochemical, Toxicological, and Pharmacological Properties of <i>Ziziphus lotus</i> (L.) Lam.: A Comprehensive Review |
| title_fullStr | Ethnobotanical, Phytochemical, Toxicological, and Pharmacological Properties of <i>Ziziphus lotus</i> (L.) Lam.: A Comprehensive Review |
| title_full_unstemmed | Ethnobotanical, Phytochemical, Toxicological, and Pharmacological Properties of <i>Ziziphus lotus</i> (L.) Lam.: A Comprehensive Review |
| title_short | Ethnobotanical, Phytochemical, Toxicological, and Pharmacological Properties of <i>Ziziphus lotus</i> (L.) Lam.: A Comprehensive Review |
| title_sort | ethnobotanical phytochemical toxicological and pharmacological properties of i ziziphus lotus i l lam a comprehensive review |
| topic | <i>Ziziphus lotus</i> (L.) Lam. ethnobotany traditional medicine phytochemical toxicological pharmacological activities |
| url | https://www.mdpi.com/1424-8247/16/4/575 |
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