β2 -Microglobulin Levels in Patients with Postmenopausal Osteoporosis
The aim of this study was to evaluate the concentrations of b2 microglobulin in patients with postmenopausal osteoporosis and compare the results with the ones obtained from healthy postmenopausal women. We also evaluated the relationships between b2 microglobulin and bone mineral density (BMD), par...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2003-06-01
|
| Series: | Türk Osteoporoz Dergisi |
| Subjects: | |
| Online Access: | http://www.turkosteoporozdergisi.org/article_4176/ve#9462-microglobulin-Levels-In-Patients-With-Postmenopausal-Osteoporosis |
| _version_ | 1797922492922200064 |
|---|---|
| author | Funda Taşçıoğlu Yıldıray Tabak Pınar Ulaşan Cengiz Öner |
| author_facet | Funda Taşçıoğlu Yıldıray Tabak Pınar Ulaşan Cengiz Öner |
| author_sort | Funda Taşçıoğlu |
| collection | DOAJ |
| description | The aim of this study was to evaluate the concentrations of b2 microglobulin in patients with postmenopausal osteoporosis and compare the results with the ones obtained from healthy postmenopausal women. We also evaluated the relationships between b2 microglobulin and bone mineral density (BMD), parathyroid hormone (PTH), calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), and 24 hr urinary calcium levels. For this aim, 31 postmenopausal women with osteoporosis and 22 healthy postmenopausal women were included in the study. DXA was used for the measurement of BMD of the lumbar spine and proximal femur. Laboratory assessments included serum Ca, P, ALP, PTH, b2 microglobulin levels and 24 hour urinary calcium. BMD at the lumbar spine (p< 0.001), femur neck (p<0.001), ward triangle (p<0.001), and trochanteric region (p<0.05) was significantly lower and serum b2 microglobulin (p<0.05), alkaline phosphotase (p<0.05), and parathyroid hormone (p<0.05) levels were found to be significantly higher in postmenopausal osteoporotic women as compared to healthy controls. However, b2 microglobulin was not associated with BMD at any of the measured regions and no association was found between serum PTH, ALP, Ca, P, and 24 hour urinary calcium values. Although high levels of b2 microglobulin in postmenopausal osteoporotic women suggest that it might reflect osteoclastic activity, the possible role of this polypeptide in the pathogenesis of increased bone resorption, needs further investigation. |
| first_indexed | 2024-04-10T14:32:13Z |
| format | Article |
| id | doaj.art-ef2bf6585e374067b31cb63e88165f87 |
| institution | Directory Open Access Journal |
| issn | 2147-2653 |
| language | English |
| last_indexed | 2024-04-10T14:32:13Z |
| publishDate | 2003-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Osteoporoz Dergisi |
| spelling | doaj.art-ef2bf6585e374067b31cb63e88165f872023-02-15T16:08:46ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532003-06-01924953β2 -Microglobulin Levels in Patients with Postmenopausal OsteoporosisFunda Taşçıoğlu0Yıldıray Tabak1Pınar Ulaşan2Cengiz Öner3Osmangazi Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim DalıOsmangazi Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim DalıOsmangazi Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim DalıOsmangazi Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim DalıThe aim of this study was to evaluate the concentrations of b2 microglobulin in patients with postmenopausal osteoporosis and compare the results with the ones obtained from healthy postmenopausal women. We also evaluated the relationships between b2 microglobulin and bone mineral density (BMD), parathyroid hormone (PTH), calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), and 24 hr urinary calcium levels. For this aim, 31 postmenopausal women with osteoporosis and 22 healthy postmenopausal women were included in the study. DXA was used for the measurement of BMD of the lumbar spine and proximal femur. Laboratory assessments included serum Ca, P, ALP, PTH, b2 microglobulin levels and 24 hour urinary calcium. BMD at the lumbar spine (p< 0.001), femur neck (p<0.001), ward triangle (p<0.001), and trochanteric region (p<0.05) was significantly lower and serum b2 microglobulin (p<0.05), alkaline phosphotase (p<0.05), and parathyroid hormone (p<0.05) levels were found to be significantly higher in postmenopausal osteoporotic women as compared to healthy controls. However, b2 microglobulin was not associated with BMD at any of the measured regions and no association was found between serum PTH, ALP, Ca, P, and 24 hour urinary calcium values. Although high levels of b2 microglobulin in postmenopausal osteoporotic women suggest that it might reflect osteoclastic activity, the possible role of this polypeptide in the pathogenesis of increased bone resorption, needs further investigation.http://www.turkosteoporozdergisi.org/article_4176/ve#9462-microglobulin-Levels-In-Patients-With-Postmenopausal-Osteoporosisb2 microglobulinpostmenopausal osteoporosis |
| spellingShingle | Funda Taşçıoğlu Yıldıray Tabak Pınar Ulaşan Cengiz Öner β2 -Microglobulin Levels in Patients with Postmenopausal Osteoporosis Türk Osteoporoz Dergisi b2 microglobulin postmenopausal osteoporosis |
| title | β2 -Microglobulin Levels in Patients with Postmenopausal Osteoporosis |
| title_full | β2 -Microglobulin Levels in Patients with Postmenopausal Osteoporosis |
| title_fullStr | β2 -Microglobulin Levels in Patients with Postmenopausal Osteoporosis |
| title_full_unstemmed | β2 -Microglobulin Levels in Patients with Postmenopausal Osteoporosis |
| title_short | β2 -Microglobulin Levels in Patients with Postmenopausal Osteoporosis |
| title_sort | β2 microglobulin levels in patients with postmenopausal osteoporosis |
| topic | b2 microglobulin postmenopausal osteoporosis |
| url | http://www.turkosteoporozdergisi.org/article_4176/ve#9462-microglobulin-Levels-In-Patients-With-Postmenopausal-Osteoporosis |
| work_keys_str_mv | AT fundatascıoglu b2microglobulinlevelsinpatientswithpostmenopausalosteoporosis AT yıldıraytabak b2microglobulinlevelsinpatientswithpostmenopausalosteoporosis AT pınarulasan b2microglobulinlevelsinpatientswithpostmenopausalosteoporosis AT cengizoner b2microglobulinlevelsinpatientswithpostmenopausalosteoporosis |