The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings
This prospective study aimed to evaluate the variation in magnetic resonance spectroscopic imaging (MRSI)-observed brain metabolite concentrations according to anatomical location, sex, and age, and the relationships among regional metabolite distributions, using short echo time (TE) whole-brain MRS...
| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
MDPI AG
2022-06-01
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| coleção: | Metabolites |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/2218-1989/12/6/543 |
| _version_ | 1827658562557444096 |
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| author | Xinnan Li Kagari Abiko Sulaiman Sheriff Andrew A. Maudsley Yuta Urushibata Sinyeob Ahn Khin Khin Tha |
| author_facet | Xinnan Li Kagari Abiko Sulaiman Sheriff Andrew A. Maudsley Yuta Urushibata Sinyeob Ahn Khin Khin Tha |
| author_sort | Xinnan Li |
| collection | DOAJ |
| description | This prospective study aimed to evaluate the variation in magnetic resonance spectroscopic imaging (MRSI)-observed brain metabolite concentrations according to anatomical location, sex, and age, and the relationships among regional metabolite distributions, using short echo time (TE) whole-brain MRSI (WB-MRSI). Thirty-eight healthy participants underwent short TE WB-MRSI. The major metabolite ratios, i.e., N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr, glutamate + glutamine (Glx)/Cr, and myoinositol (mI)/Cr, were calculated voxel-by-voxel. Their variations according to anatomical regions, sex, and age, and their relationship to each other were evaluated by using repeated-measures analysis of variance, t-tests, and Pearson’s product-moment correlation analyses. All four metabolite ratios exhibited widespread regional variation across the cerebral hemispheres (corrected <i>p</i> < 0.05). Laterality between the two sides and sex-related variation were also shown (<i>p</i> < 0.05). In several regions, NAA/Cr and Glx/Cr decreased and mI/Cr increased with age (corrected <i>p</i> < 0.05). There was a moderate positive correlation between NAA/Cr and mI/Cr in the insular lobe and thalamus and between Glx/Cr and mI/Cr in the parietal lobe (r ≥ 0.348, corrected <i>p</i> ≤ 0.025). These observations demand age- and sex- specific regional reference values in interpreting these metabolites, and they may facilitate the understanding of glial-neuronal interactions in maintaining homeostasis. |
| first_indexed | 2024-03-09T23:04:28Z |
| format | Article |
| id | doaj.art-ef2d35b2ccd64ea5815ae0b02f11028d |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T23:04:28Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ef2d35b2ccd64ea5815ae0b02f11028d2023-11-23T17:56:24ZengMDPI AGMetabolites2218-19892022-06-0112654310.3390/metabo12060543The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging FindingsXinnan Li0Kagari Abiko1Sulaiman Sheriff2Andrew A. Maudsley3Yuta Urushibata4Sinyeob Ahn5Khin Khin Tha6Laboratory for Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo 060-8638, JapanDepartment of Rehabilitation, Hokkaido University Hospital, Sapporo 060-8648, JapanDepartment of Radiology, University of Miami School of Medicine, Miami, FL 33146, USADepartment of Radiology, University of Miami School of Medicine, Miami, FL 33146, USASiemens Healthcare K.K., Tokyo 141-8644, JapanSiemens Healthineers, San Francisco, CA 94553, USALaboratory for Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo 060-8638, JapanThis prospective study aimed to evaluate the variation in magnetic resonance spectroscopic imaging (MRSI)-observed brain metabolite concentrations according to anatomical location, sex, and age, and the relationships among regional metabolite distributions, using short echo time (TE) whole-brain MRSI (WB-MRSI). Thirty-eight healthy participants underwent short TE WB-MRSI. The major metabolite ratios, i.e., N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr, glutamate + glutamine (Glx)/Cr, and myoinositol (mI)/Cr, were calculated voxel-by-voxel. Their variations according to anatomical regions, sex, and age, and their relationship to each other were evaluated by using repeated-measures analysis of variance, t-tests, and Pearson’s product-moment correlation analyses. All four metabolite ratios exhibited widespread regional variation across the cerebral hemispheres (corrected <i>p</i> < 0.05). Laterality between the two sides and sex-related variation were also shown (<i>p</i> < 0.05). In several regions, NAA/Cr and Glx/Cr decreased and mI/Cr increased with age (corrected <i>p</i> < 0.05). There was a moderate positive correlation between NAA/Cr and mI/Cr in the insular lobe and thalamus and between Glx/Cr and mI/Cr in the parietal lobe (r ≥ 0.348, corrected <i>p</i> ≤ 0.025). These observations demand age- and sex- specific regional reference values in interpreting these metabolites, and they may facilitate the understanding of glial-neuronal interactions in maintaining homeostasis.https://www.mdpi.com/2218-1989/12/6/543echo-planarmagnetic resonance spectroscopic imagingmetabolitewhole-brain |
| spellingShingle | Xinnan Li Kagari Abiko Sulaiman Sheriff Andrew A. Maudsley Yuta Urushibata Sinyeob Ahn Khin Khin Tha The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings Metabolites echo-planar magnetic resonance spectroscopic imaging metabolite whole-brain |
| title | The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings |
| title_full | The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings |
| title_fullStr | The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings |
| title_full_unstemmed | The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings |
| title_short | The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings |
| title_sort | distribution of major brain metabolites in normal adults short echo time whole brain mr spectroscopic imaging findings |
| topic | echo-planar magnetic resonance spectroscopic imaging metabolite whole-brain |
| url | https://www.mdpi.com/2218-1989/12/6/543 |
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