Impact of Different Types of Nosocomial Infection on the Neurodevelopmental Outcome of Very Low Birth Weight Infants
Nosocomial infections (NIs) are important conditions associated with mortality and morbidity in very low birth weight infants (VLBWIs). The aim of this study was to investigate the impact of NIs and the different subtypes on neurodevelopmental outcomes in a cohort of VLBWIs. VLBWIs born with a gesta...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/3/207 |
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| author | Karin Pichler Vito Giordano Gereon Tropf Renate Fuiko Angelika Berger Judith Rittenschober-Boehm |
| author_facet | Karin Pichler Vito Giordano Gereon Tropf Renate Fuiko Angelika Berger Judith Rittenschober-Boehm |
| author_sort | Karin Pichler |
| collection | DOAJ |
| description | Nosocomial infections (NIs) are important conditions associated with mortality and morbidity in very low birth weight infants (VLBWIs). The aim of this study was to investigate the impact of NIs and the different subtypes on neurodevelopmental outcomes in a cohort of VLBWIs. VLBWIs born with a gestational age between 23 <sup>0/7</sup> and 31 <sup>6/7</sup> weeks in a level III neonatal center were enrolled. Neonatal morbidities as well as the neurodevelopmental outcome at 2 years of corrected age were analyzed. Six-hundred infants completed the study successfully. Of these, 38% experienced an NI episode. NIs were associated with an increased risk of neonatal complications, such as brain injury, bronchopulmonary dysplasia (BPD) and death, and were a significant risk factor for adverse motor development at 2 years of corrected age in our cohort of VLBWIs. The negative impact of NIs on neurodevelopmental outcomes was particularly associated with necrotizing enterocolitis (NEC), suspected NIs and Gram-positive NIs. This study demonstrated that NIs are a significant risk factor for both morbidity and mortality as well as adverse neurodevelopmental outcomes in VLBWIs. |
| first_indexed | 2024-03-10T13:25:40Z |
| format | Article |
| id | doaj.art-ef2d3d6377d0418fb71e67f92eca3642 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T13:25:40Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-ef2d3d6377d0418fb71e67f92eca36422023-11-21T09:42:47ZengMDPI AGChildren2227-90672021-03-018320710.3390/children8030207Impact of Different Types of Nosocomial Infection on the Neurodevelopmental Outcome of Very Low Birth Weight InfantsKarin Pichler0Vito Giordano1Gereon Tropf2Renate Fuiko3Angelika Berger4Judith Rittenschober-Boehm5Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, AustriaDivision of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, AustriaDivision of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, AustriaDivision of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, AustriaDivision of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, AustriaDivision of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, AustriaNosocomial infections (NIs) are important conditions associated with mortality and morbidity in very low birth weight infants (VLBWIs). The aim of this study was to investigate the impact of NIs and the different subtypes on neurodevelopmental outcomes in a cohort of VLBWIs. VLBWIs born with a gestational age between 23 <sup>0/7</sup> and 31 <sup>6/7</sup> weeks in a level III neonatal center were enrolled. Neonatal morbidities as well as the neurodevelopmental outcome at 2 years of corrected age were analyzed. Six-hundred infants completed the study successfully. Of these, 38% experienced an NI episode. NIs were associated with an increased risk of neonatal complications, such as brain injury, bronchopulmonary dysplasia (BPD) and death, and were a significant risk factor for adverse motor development at 2 years of corrected age in our cohort of VLBWIs. The negative impact of NIs on neurodevelopmental outcomes was particularly associated with necrotizing enterocolitis (NEC), suspected NIs and Gram-positive NIs. This study demonstrated that NIs are a significant risk factor for both morbidity and mortality as well as adverse neurodevelopmental outcomes in VLBWIs.https://www.mdpi.com/2227-9067/8/3/207nosocomial infectionvery low birth weight infantsneurodevelopmental outcome |
| spellingShingle | Karin Pichler Vito Giordano Gereon Tropf Renate Fuiko Angelika Berger Judith Rittenschober-Boehm Impact of Different Types of Nosocomial Infection on the Neurodevelopmental Outcome of Very Low Birth Weight Infants Children nosocomial infection very low birth weight infants neurodevelopmental outcome |
| title | Impact of Different Types of Nosocomial Infection on the Neurodevelopmental Outcome of Very Low Birth Weight Infants |
| title_full | Impact of Different Types of Nosocomial Infection on the Neurodevelopmental Outcome of Very Low Birth Weight Infants |
| title_fullStr | Impact of Different Types of Nosocomial Infection on the Neurodevelopmental Outcome of Very Low Birth Weight Infants |
| title_full_unstemmed | Impact of Different Types of Nosocomial Infection on the Neurodevelopmental Outcome of Very Low Birth Weight Infants |
| title_short | Impact of Different Types of Nosocomial Infection on the Neurodevelopmental Outcome of Very Low Birth Weight Infants |
| title_sort | impact of different types of nosocomial infection on the neurodevelopmental outcome of very low birth weight infants |
| topic | nosocomial infection very low birth weight infants neurodevelopmental outcome |
| url | https://www.mdpi.com/2227-9067/8/3/207 |
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