Evaluation of contrast-induced acute kidney injury using IVIM and DKI MRI in a rat model of diabetic nephropathy
Abstract Objective To assess the potential of intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) in monitoring renal changes in a diabetic nephropathy (DN) rat model with acute kidney injury (CI-AKI) induced by iso-osmotic contrast media (IOCM) and low-osmotic contrast media (L...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-06-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-022-01249-w |
| _version_ | 1818470915055288320 |
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| author | Hongyan Dai Chun Zhao Yuxin Xiong Qian He Wei Su Jianbo Li Ying Yang Ruyun Lin Shutian Xiang Juwei Shao |
| author_facet | Hongyan Dai Chun Zhao Yuxin Xiong Qian He Wei Su Jianbo Li Ying Yang Ruyun Lin Shutian Xiang Juwei Shao |
| author_sort | Hongyan Dai |
| collection | DOAJ |
| description | Abstract Objective To assess the potential of intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) in monitoring renal changes in a diabetic nephropathy (DN) rat model with acute kidney injury (CI-AKI) induced by iso-osmotic contrast media (IOCM) and low-osmotic contrast media (LOCM). Methods A diabetic nephropathy rat model was established, and the animals were randomly split into the LOCM group and IOCM group (n = 13 per group), with iopamidol and iodixanol injection, respectively (4 g iodine/kg). MRI including IVIM and DKI was performed 24 h before contrast medium injections (baseline) and 1, 24, 48, and 72 h after injections. Changes in pure molecular diffusion (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), mean diffusion (MD), mean kurtosis (MK), serum creatinine (SCr) and urea nitrogen (BUN), histopathology alterations, and α-smooth muscle actin (α-SMA) expression were assessed. Inter-observer agreement was evaluated using the intraclass correlation coefficient (ICC). Results Compared against baseline levels, significant decreases in D, D*, and f were observed in all anatomical kidney compartments after contrast injection (p < 0.05). MD in the cortex (CO) and outer medullary (OM) gradually decreased, and MK in OM gradually increased 24–72 h after injection. D, D*, f, and MD were negatively correlated with the histopathologic findings and α-smooth muscle actin (α-SMA) expression in all anatomical kidney compartments. Inter-observer reproducibility was generally good (ICCs ranging from 0.776 to 0.979). Conclusions IVIM and DKI provided noninvasive imaging parameters, which might offer effective detection of CI-AKI in DN. |
| first_indexed | 2024-04-13T21:43:56Z |
| format | Article |
| id | doaj.art-ef2d9e887dea438a8be8901e3548f93a |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-04-13T21:43:56Z |
| publishDate | 2022-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-ef2d9e887dea438a8be8901e3548f93a2022-12-22T02:28:40ZengSpringerOpenInsights into Imaging1869-41012022-06-0113111210.1186/s13244-022-01249-wEvaluation of contrast-induced acute kidney injury using IVIM and DKI MRI in a rat model of diabetic nephropathyHongyan Dai0Chun Zhao1Yuxin Xiong2Qian He3Wei Su4Jianbo Li5Ying Yang6Ruyun Lin7Shutian Xiang8Juwei Shao9Department of Radiology, The Affiliated Hospital of Yunnan UniversityDepartment of Radiology, The Affiliated Hospital of Yunnan UniversityDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Yunnan UniversityDepartment of Radiology, The Affiliated Hospital of Yunnan UniversityDepartment of Radiology, The Affiliated Hospital of Yunnan UniversityDepartment of Radiology, The Affiliated Hospital of Yunnan UniversityDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Yunnan UniversityDepartment of Hospital Quality Control, The Affiliated Hospital of Yunnan UniversityDepartment of Radiology, The Affiliated Hospital of Yunnan UniversityDepartment of Radiology, The Affiliated Hospital of Yunnan UniversityAbstract Objective To assess the potential of intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) in monitoring renal changes in a diabetic nephropathy (DN) rat model with acute kidney injury (CI-AKI) induced by iso-osmotic contrast media (IOCM) and low-osmotic contrast media (LOCM). Methods A diabetic nephropathy rat model was established, and the animals were randomly split into the LOCM group and IOCM group (n = 13 per group), with iopamidol and iodixanol injection, respectively (4 g iodine/kg). MRI including IVIM and DKI was performed 24 h before contrast medium injections (baseline) and 1, 24, 48, and 72 h after injections. Changes in pure molecular diffusion (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), mean diffusion (MD), mean kurtosis (MK), serum creatinine (SCr) and urea nitrogen (BUN), histopathology alterations, and α-smooth muscle actin (α-SMA) expression were assessed. Inter-observer agreement was evaluated using the intraclass correlation coefficient (ICC). Results Compared against baseline levels, significant decreases in D, D*, and f were observed in all anatomical kidney compartments after contrast injection (p < 0.05). MD in the cortex (CO) and outer medullary (OM) gradually decreased, and MK in OM gradually increased 24–72 h after injection. D, D*, f, and MD were negatively correlated with the histopathologic findings and α-smooth muscle actin (α-SMA) expression in all anatomical kidney compartments. Inter-observer reproducibility was generally good (ICCs ranging from 0.776 to 0.979). Conclusions IVIM and DKI provided noninvasive imaging parameters, which might offer effective detection of CI-AKI in DN.https://doi.org/10.1186/s13244-022-01249-wContrast-induced acute kidney injuryDiabetic nephropathyIodinated contrast mediaIntravoxel incoherent motionDiffusion kurtosis imaging |
| spellingShingle | Hongyan Dai Chun Zhao Yuxin Xiong Qian He Wei Su Jianbo Li Ying Yang Ruyun Lin Shutian Xiang Juwei Shao Evaluation of contrast-induced acute kidney injury using IVIM and DKI MRI in a rat model of diabetic nephropathy Insights into Imaging Contrast-induced acute kidney injury Diabetic nephropathy Iodinated contrast media Intravoxel incoherent motion Diffusion kurtosis imaging |
| title | Evaluation of contrast-induced acute kidney injury using IVIM and DKI MRI in a rat model of diabetic nephropathy |
| title_full | Evaluation of contrast-induced acute kidney injury using IVIM and DKI MRI in a rat model of diabetic nephropathy |
| title_fullStr | Evaluation of contrast-induced acute kidney injury using IVIM and DKI MRI in a rat model of diabetic nephropathy |
| title_full_unstemmed | Evaluation of contrast-induced acute kidney injury using IVIM and DKI MRI in a rat model of diabetic nephropathy |
| title_short | Evaluation of contrast-induced acute kidney injury using IVIM and DKI MRI in a rat model of diabetic nephropathy |
| title_sort | evaluation of contrast induced acute kidney injury using ivim and dki mri in a rat model of diabetic nephropathy |
| topic | Contrast-induced acute kidney injury Diabetic nephropathy Iodinated contrast media Intravoxel incoherent motion Diffusion kurtosis imaging |
| url | https://doi.org/10.1186/s13244-022-01249-w |
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