Bacteriophage–Antibiotic Combination Therapy against <i>Pseudomonas aeruginosa</i>
Phage therapy is an alternative therapy that is being used as the last resource against infections caused by multidrug-resistant bacteria after the failure of standard treatments. <i>Pseudomonas aeruginosa</i> can cause pneumonia, septicemia, urinary tract, and surgery site infections ma...
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Format: | Article |
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MDPI AG
2023-06-01
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Series: | Antibiotics |
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Online Access: | https://www.mdpi.com/2079-6382/12/7/1089 |
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author | Guillermo Santamaría-Corral Abrar Senhaji-Kacha Antonio Broncano-Lavado Jaime Esteban Meritxell García-Quintanilla |
author_facet | Guillermo Santamaría-Corral Abrar Senhaji-Kacha Antonio Broncano-Lavado Jaime Esteban Meritxell García-Quintanilla |
author_sort | Guillermo Santamaría-Corral |
collection | DOAJ |
description | Phage therapy is an alternative therapy that is being used as the last resource against infections caused by multidrug-resistant bacteria after the failure of standard treatments. <i>Pseudomonas aeruginosa</i> can cause pneumonia, septicemia, urinary tract, and surgery site infections mainly in immunocompromised people, although it can cause infections in many different patient profiles. Cystic fibrosis patients are particularly vulnerable. In vitro and in vivo studies of phage therapy against <i>P. aeruginosa</i> include both bacteriophages alone and combined with antibiotics. However, the former is the most promising strategy utilized in clinical infections. This review summarizes the recent studies of phage-antibiotic combinations, highlighting the synergistic effects of in vitro and in vivo experiments and successful treatments in patients. |
first_indexed | 2024-03-11T01:23:03Z |
format | Article |
id | doaj.art-ef2ee4f89da5433fac06fbee8941dd55 |
institution | Directory Open Access Journal |
issn | 2079-6382 |
language | English |
last_indexed | 2024-03-11T01:23:03Z |
publishDate | 2023-06-01 |
publisher | MDPI AG |
record_format | Article |
series | Antibiotics |
spelling | doaj.art-ef2ee4f89da5433fac06fbee8941dd552023-11-18T18:02:01ZengMDPI AGAntibiotics2079-63822023-06-01127108910.3390/antibiotics12071089Bacteriophage–Antibiotic Combination Therapy against <i>Pseudomonas aeruginosa</i>Guillermo Santamaría-Corral0Abrar Senhaji-Kacha1Antonio Broncano-Lavado2Jaime Esteban3Meritxell García-Quintanilla4Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Av. Reyes Católicos 2, 28040 Madrid, SpainDepartment of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Av. Reyes Católicos 2, 28040 Madrid, SpainDepartment of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Av. Reyes Católicos 2, 28040 Madrid, SpainDepartment of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Av. Reyes Católicos 2, 28040 Madrid, SpainDepartment of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Av. Reyes Católicos 2, 28040 Madrid, SpainPhage therapy is an alternative therapy that is being used as the last resource against infections caused by multidrug-resistant bacteria after the failure of standard treatments. <i>Pseudomonas aeruginosa</i> can cause pneumonia, septicemia, urinary tract, and surgery site infections mainly in immunocompromised people, although it can cause infections in many different patient profiles. Cystic fibrosis patients are particularly vulnerable. In vitro and in vivo studies of phage therapy against <i>P. aeruginosa</i> include both bacteriophages alone and combined with antibiotics. However, the former is the most promising strategy utilized in clinical infections. This review summarizes the recent studies of phage-antibiotic combinations, highlighting the synergistic effects of in vitro and in vivo experiments and successful treatments in patients.https://www.mdpi.com/2079-6382/12/7/1089<i>Pseudomonas aeruginosa</i>treatmentbacteriophagecombination |
spellingShingle | Guillermo Santamaría-Corral Abrar Senhaji-Kacha Antonio Broncano-Lavado Jaime Esteban Meritxell García-Quintanilla Bacteriophage–Antibiotic Combination Therapy against <i>Pseudomonas aeruginosa</i> Antibiotics <i>Pseudomonas aeruginosa</i> treatment bacteriophage combination |
title | Bacteriophage–Antibiotic Combination Therapy against <i>Pseudomonas aeruginosa</i> |
title_full | Bacteriophage–Antibiotic Combination Therapy against <i>Pseudomonas aeruginosa</i> |
title_fullStr | Bacteriophage–Antibiotic Combination Therapy against <i>Pseudomonas aeruginosa</i> |
title_full_unstemmed | Bacteriophage–Antibiotic Combination Therapy against <i>Pseudomonas aeruginosa</i> |
title_short | Bacteriophage–Antibiotic Combination Therapy against <i>Pseudomonas aeruginosa</i> |
title_sort | bacteriophage antibiotic combination therapy against i pseudomonas aeruginosa i |
topic | <i>Pseudomonas aeruginosa</i> treatment bacteriophage combination |
url | https://www.mdpi.com/2079-6382/12/7/1089 |
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