Asymmetric PTEN distribution regulated by spatial heterogeneity in membrane-binding state transitions.

Asymmetric PTEN distribution regulated by spatial heterogeneity in membrane-binding state transitions.

The molecular mechanisms that underlie asymmetric PTEN distribution at the posterior of polarized motile cells and regulate anterior pseudopod formation were addressed by novel single-molecule tracking analysis. Heterogeneity in the lateral mobility of PTEN on a membrane indicated the existence of t...

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Bibliographic Details
Main Authors: Satomi Matsuoka, Tatsuo Shibata, Masahiro Ueda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3542079?pdf=render

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