Myelosuppression in Patients Treated with the Telomerase Inhibitor Imetelstat Is Not Mediated through Activation of Toll-Like Receptors

Myelosuppression in Patients Treated with the Telomerase Inhibitor Imetelstat Is Not Mediated through Activation of Toll-Like Receptors

Imetelstat sodium (GRN163L; hereafter, imetelstat) is a first-in-class telomerase inhibitor that has demonstrated activity in patients with myeloproliferative neoplasms (MPNs). Treatment with imetelstat has been associated with thrombocytopenia and other hematologic adverse effects that were managea...

Full description

Bibliographic Details
Main Authors: Gabriela M. Baerlocher, Joshua Rusbuldt, Jacqueline Bussolari, Fei Huang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
imetelstat
thrombocytopenia
Toll-like receptor
telomerase inhibitor
oligonucleotide
Online Access:https://www.mdpi.com/1422-0067/21/18/6550

Similar Items

Similar Items