Engineering natural molecule-triggered genetic control systems for tunable gene- and cell-based therapies
The ability to precisely control activities of engineered designer cells provides a novel strategy for modern precision medicine. Dynamically adjustable gene- and cell-based precision therapies are recognized as next generation medicines. However, the translation of these controllable therapeutics i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Synthetic and Systems Biotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405805X23000479 |
| _version_ | 1797727677429317632 |
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| author | Xinyi Wang Xuantong Zhou Liping Kang Yuqin Lai Haifeng Ye |
| author_facet | Xinyi Wang Xuantong Zhou Liping Kang Yuqin Lai Haifeng Ye |
| author_sort | Xinyi Wang |
| collection | DOAJ |
| description | The ability to precisely control activities of engineered designer cells provides a novel strategy for modern precision medicine. Dynamically adjustable gene- and cell-based precision therapies are recognized as next generation medicines. However, the translation of these controllable therapeutics into clinical practice is severely hampered by the lack of safe and highly specific genetic switches controlled by triggers that are nontoxic and side-effect free. Recently, natural products derived from plants have been extensively explored as trigger molecules to control genetic switches and synthetic gene networks for multiple applications. These controlled genetic switches could be further introduced into mammalian cells to obtain synthetic designer cells for adjustable and fine tunable cell-based precision therapy. In this review, we introduce various available natural molecules that were engineered to control genetic switches for controllable transgene expression, complex logic computation, and therapeutic drug delivery to achieve precision therapy. We also discuss current challenges and prospects in translating these natural molecule-controlled genetic switches developed for biomedical applications from the laboratory to the clinic. |
| first_indexed | 2024-03-12T11:03:01Z |
| format | Article |
| id | doaj.art-ef33df84e13c475a88a7f6c907fed9dc |
| institution | Directory Open Access Journal |
| issn | 2405-805X |
| language | English |
| last_indexed | 2024-03-12T11:03:01Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Synthetic and Systems Biotechnology |
| spelling | doaj.art-ef33df84e13c475a88a7f6c907fed9dc2023-09-02T04:31:52ZengKeAi Communications Co., Ltd.Synthetic and Systems Biotechnology2405-805X2023-09-0183416426Engineering natural molecule-triggered genetic control systems for tunable gene- and cell-based therapiesXinyi Wang0Xuantong Zhou1Liping Kang2Yuqin Lai3Haifeng Ye4Synthetic Biology and Biomedical Engineering Laboratory, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, ChinaSynthetic Biology and Biomedical Engineering Laboratory, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, ChinaSynthetic Biology and Biomedical Engineering Laboratory, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, ChinaSynthetic Biology and Biomedical Engineering Laboratory, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, ChinaCorresponding author.; Synthetic Biology and Biomedical Engineering Laboratory, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, ChinaThe ability to precisely control activities of engineered designer cells provides a novel strategy for modern precision medicine. Dynamically adjustable gene- and cell-based precision therapies are recognized as next generation medicines. However, the translation of these controllable therapeutics into clinical practice is severely hampered by the lack of safe and highly specific genetic switches controlled by triggers that are nontoxic and side-effect free. Recently, natural products derived from plants have been extensively explored as trigger molecules to control genetic switches and synthetic gene networks for multiple applications. These controlled genetic switches could be further introduced into mammalian cells to obtain synthetic designer cells for adjustable and fine tunable cell-based precision therapy. In this review, we introduce various available natural molecules that were engineered to control genetic switches for controllable transgene expression, complex logic computation, and therapeutic drug delivery to achieve precision therapy. We also discuss current challenges and prospects in translating these natural molecule-controlled genetic switches developed for biomedical applications from the laboratory to the clinic.http://www.sciencedirect.com/science/article/pii/S2405805X23000479Mammalian synthetic biologyNatural moleculesGenetic switchesGene- and cell-based therapyPrecision medicine |
| spellingShingle | Xinyi Wang Xuantong Zhou Liping Kang Yuqin Lai Haifeng Ye Engineering natural molecule-triggered genetic control systems for tunable gene- and cell-based therapies Synthetic and Systems Biotechnology Mammalian synthetic biology Natural molecules Genetic switches Gene- and cell-based therapy Precision medicine |
| title | Engineering natural molecule-triggered genetic control systems for tunable gene- and cell-based therapies |
| title_full | Engineering natural molecule-triggered genetic control systems for tunable gene- and cell-based therapies |
| title_fullStr | Engineering natural molecule-triggered genetic control systems for tunable gene- and cell-based therapies |
| title_full_unstemmed | Engineering natural molecule-triggered genetic control systems for tunable gene- and cell-based therapies |
| title_short | Engineering natural molecule-triggered genetic control systems for tunable gene- and cell-based therapies |
| title_sort | engineering natural molecule triggered genetic control systems for tunable gene and cell based therapies |
| topic | Mammalian synthetic biology Natural molecules Genetic switches Gene- and cell-based therapy Precision medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2405805X23000479 |
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