Post-Stroke Cognitive Impairment: Pathophysiological Insights into Brain Disconnectome from Advanced Neuroimaging Analysis Techniques
The neurological symptoms of stroke have traditionally provided the foundation for functional mapping of the brain. However, there are many unresolved aspects in our understanding of cerebral activity, especially regarding high-level cognitive functions. This review provides a comprehensive look at...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Stroke Society
2021-09-01
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| Series: | Journal of Stroke |
| Subjects: | |
| Online Access: | http://www.j-stroke.org/upload/pdf/jos-2021-02376.pdf |
| _version_ | 1818689564145876992 |
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| author | Jae-Sung Lim Jae-Joong Lee Choong-Wan Woo |
| author_facet | Jae-Sung Lim Jae-Joong Lee Choong-Wan Woo |
| author_sort | Jae-Sung Lim |
| collection | DOAJ |
| description | The neurological symptoms of stroke have traditionally provided the foundation for functional mapping of the brain. However, there are many unresolved aspects in our understanding of cerebral activity, especially regarding high-level cognitive functions. This review provides a comprehensive look at the pathophysiology of post-stroke cognitive impairment in light of recent findings from advanced imaging techniques. Combining network neuroscience and clinical neurology, our research focuses on how changes in brain networks correlate with post-stroke cognitive prognosis. More specifically, we first discuss the general consequences of stroke lesions due to damage of canonical resting-state large-scale networks or changes in the composition of the entire brain. We also review emerging methods, such as lesion-network mapping and gradient analysis, used to study the aforementioned events caused by stroke lesions. Lastly, we examine other patient vulnerabilities, such as superimposed amyloid pathology and blood-brain barrier leakage, which potentially lead to different outcomes for the brain network compositions even in the presence of similar stroke lesions. This knowledge will allow a better understanding of the pathophysiology of post-stroke cognitive impairment and provide a theoretical basis for the development of new treatments, such as neuromodulation. |
| first_indexed | 2024-12-17T12:12:06Z |
| format | Article |
| id | doaj.art-ef3484bf5f5e40069728f2c4180806d5 |
| institution | Directory Open Access Journal |
| issn | 2287-6391 2287-6405 |
| language | English |
| last_indexed | 2024-12-17T12:12:06Z |
| publishDate | 2021-09-01 |
| publisher | Korean Stroke Society |
| record_format | Article |
| series | Journal of Stroke |
| spelling | doaj.art-ef3484bf5f5e40069728f2c4180806d52022-12-21T21:49:23ZengKorean Stroke SocietyJournal of Stroke2287-63912287-64052021-09-0123329731110.5853/jos.2021.02376388Post-Stroke Cognitive Impairment: Pathophysiological Insights into Brain Disconnectome from Advanced Neuroimaging Analysis TechniquesJae-Sung Lim0Jae-Joong Lee1Choong-Wan Woo2 Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea Department of Biomedical Engineering, Sungkyunkwan University, Suwon, KoreaThe neurological symptoms of stroke have traditionally provided the foundation for functional mapping of the brain. However, there are many unresolved aspects in our understanding of cerebral activity, especially regarding high-level cognitive functions. This review provides a comprehensive look at the pathophysiology of post-stroke cognitive impairment in light of recent findings from advanced imaging techniques. Combining network neuroscience and clinical neurology, our research focuses on how changes in brain networks correlate with post-stroke cognitive prognosis. More specifically, we first discuss the general consequences of stroke lesions due to damage of canonical resting-state large-scale networks or changes in the composition of the entire brain. We also review emerging methods, such as lesion-network mapping and gradient analysis, used to study the aforementioned events caused by stroke lesions. Lastly, we examine other patient vulnerabilities, such as superimposed amyloid pathology and blood-brain barrier leakage, which potentially lead to different outcomes for the brain network compositions even in the presence of similar stroke lesions. This knowledge will allow a better understanding of the pathophysiology of post-stroke cognitive impairment and provide a theoretical basis for the development of new treatments, such as neuromodulation.http://www.j-stroke.org/upload/pdf/jos-2021-02376.pdfstrokecognitive dysfunctiondementianeuroimagingbrain mappingconnectome |
| spellingShingle | Jae-Sung Lim Jae-Joong Lee Choong-Wan Woo Post-Stroke Cognitive Impairment: Pathophysiological Insights into Brain Disconnectome from Advanced Neuroimaging Analysis Techniques Journal of Stroke stroke cognitive dysfunction dementia neuroimaging brain mapping connectome |
| title | Post-Stroke Cognitive Impairment: Pathophysiological Insights into Brain Disconnectome from Advanced Neuroimaging Analysis Techniques |
| title_full | Post-Stroke Cognitive Impairment: Pathophysiological Insights into Brain Disconnectome from Advanced Neuroimaging Analysis Techniques |
| title_fullStr | Post-Stroke Cognitive Impairment: Pathophysiological Insights into Brain Disconnectome from Advanced Neuroimaging Analysis Techniques |
| title_full_unstemmed | Post-Stroke Cognitive Impairment: Pathophysiological Insights into Brain Disconnectome from Advanced Neuroimaging Analysis Techniques |
| title_short | Post-Stroke Cognitive Impairment: Pathophysiological Insights into Brain Disconnectome from Advanced Neuroimaging Analysis Techniques |
| title_sort | post stroke cognitive impairment pathophysiological insights into brain disconnectome from advanced neuroimaging analysis techniques |
| topic | stroke cognitive dysfunction dementia neuroimaging brain mapping connectome |
| url | http://www.j-stroke.org/upload/pdf/jos-2021-02376.pdf |
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