Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice
The goal of the study was to find out the toxic effect of daily treatment with α-Fe2O3 nanoparticles for 14 and 28 days on some biochemical indicators in mice by measuring ferritin, transferrin, cholinesterase enzyme activity, the concentration of Caspase-3, and the concentration of glutathione and...
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| Format: | Article |
| Language: | English |
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Egyptian Society for Animal Management
2023-07-01
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| Series: | Journal of Applied Veterinary Sciences |
| Subjects: | |
| Online Access: | https://javs.journals.ekb.eg/article_304730_f1ff86a1c69c7d26e56b82cd8f050f97.pdf |
| _version_ | 1797782381617217536 |
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| author | Nashwan Al-hamadany Muna Azubaidy |
| author_facet | Nashwan Al-hamadany Muna Azubaidy |
| author_sort | Nashwan Al-hamadany |
| collection | DOAJ |
| description | The goal of the study was to find out the toxic effect of daily treatment with α-Fe2O3 nanoparticles for 14 and 28 days on some biochemical indicators in mice by measuring ferritin, transferrin, cholinesterase enzyme activity, the concentration of Caspase-3, and the concentration of glutathione and malondehyde in brain and liver tissues at doses of 75, 150 and 300 mg/kg. α-Fe2O3 nanoparticles at the dose of 75 mg/kg caused a significant decrease in the activity of the acetyl cholinesterase enzyme in the brain and liver after 14 days of treatment, compared with the control group and the doses of α- Fe2O3 (75, 150, and 300 mg/kg) led to a significant decrease in the activity of the acetyl cholinesterase enzyme in the brain after 28 days of treatment. Fe2O3 at a dose of 75 mg/kg on the 14th day and at a dose of 150 mg/kg on the 28th day of treatment resulted in a significant increase in the caspase-3 enzyme in the brain compared to the control group. While the doses of 150 and 300 mg/kg for 28 days led to a significant increase in transferrin concentration compared with the control group, The α-Fe2O3 nanoparticles at doses of 75, 150, and 300 mg/kg for 28 days caused a significant decrease in the concentration of glutathione in the liver and brain tissues compared with the control group, accompanied by a significant increase in the concentration of malondehyde in the brain and liver tissues at doses of 150 and 300 mg/kg of body weight. We conclude that repeated exposure to α - Fe2O3 nanoparticles has toxic effects on vital organs such as the brain and liver, represented by a decrease in the concentration of acetylcholinesterase and its ability to induce oxidative stress through a decrease in glutathione concentration and an increase in malondehyde concentration in mice . |
| first_indexed | 2024-03-13T00:10:10Z |
| format | Article |
| id | doaj.art-ef352221a7284986b076b60d2fb8f239 |
| institution | Directory Open Access Journal |
| issn | 1687-4072 2090-3308 |
| language | English |
| last_indexed | 2024-03-13T00:10:10Z |
| publishDate | 2023-07-01 |
| publisher | Egyptian Society for Animal Management |
| record_format | Article |
| series | Journal of Applied Veterinary Sciences |
| spelling | doaj.art-ef352221a7284986b076b60d2fb8f2392023-07-12T19:03:15ZengEgyptian Society for Animal ManagementJournal of Applied Veterinary Sciences1687-40722090-33082023-07-0183465310.21608/javs.2023.210749.1232304730Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in MiceNashwan Al-hamadany0Muna Azubaidy1Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqThe goal of the study was to find out the toxic effect of daily treatment with α-Fe2O3 nanoparticles for 14 and 28 days on some biochemical indicators in mice by measuring ferritin, transferrin, cholinesterase enzyme activity, the concentration of Caspase-3, and the concentration of glutathione and malondehyde in brain and liver tissues at doses of 75, 150 and 300 mg/kg. α-Fe2O3 nanoparticles at the dose of 75 mg/kg caused a significant decrease in the activity of the acetyl cholinesterase enzyme in the brain and liver after 14 days of treatment, compared with the control group and the doses of α- Fe2O3 (75, 150, and 300 mg/kg) led to a significant decrease in the activity of the acetyl cholinesterase enzyme in the brain after 28 days of treatment. Fe2O3 at a dose of 75 mg/kg on the 14th day and at a dose of 150 mg/kg on the 28th day of treatment resulted in a significant increase in the caspase-3 enzyme in the brain compared to the control group. While the doses of 150 and 300 mg/kg for 28 days led to a significant increase in transferrin concentration compared with the control group, The α-Fe2O3 nanoparticles at doses of 75, 150, and 300 mg/kg for 28 days caused a significant decrease in the concentration of glutathione in the liver and brain tissues compared with the control group, accompanied by a significant increase in the concentration of malondehyde in the brain and liver tissues at doses of 150 and 300 mg/kg of body weight. We conclude that repeated exposure to α - Fe2O3 nanoparticles has toxic effects on vital organs such as the brain and liver, represented by a decrease in the concentration of acetylcholinesterase and its ability to induce oxidative stress through a decrease in glutathione concentration and an increase in malondehyde concentration in mice .https://javs.journals.ekb.eg/article_304730_f1ff86a1c69c7d26e56b82cd8f050f97.pdfacetyl cholinesteraseα-fe2o3 ferritinnanoparticlesoxidative stresstransferrin |
| spellingShingle | Nashwan Al-hamadany Muna Azubaidy Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice Journal of Applied Veterinary Sciences acetyl cholinesterase α-fe2o3 ferritin nanoparticles oxidative stress transferrin |
| title | Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice |
| title_full | Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice |
| title_fullStr | Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice |
| title_full_unstemmed | Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice |
| title_short | Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice |
| title_sort | sub acute effects of α fe2o3 nanoparticles on some biochemical parameters in mice |
| topic | acetyl cholinesterase α-fe2o3 ferritin nanoparticles oxidative stress transferrin |
| url | https://javs.journals.ekb.eg/article_304730_f1ff86a1c69c7d26e56b82cd8f050f97.pdf |
| work_keys_str_mv | AT nashwanalhamadany subacuteeffectsofafe2o3nanoparticlesonsomebiochemicalparametersinmice AT munaazubaidy subacuteeffectsofafe2o3nanoparticlesonsomebiochemicalparametersinmice |