Age-Related Features of Reactive Catecholamine Shifts in the Spinal Cord in Acute Somatic Pain: Experimental Study
Objective: to study the age-related features of an adrenergic response of the central nervous system to acute somatic pain (ASP).Subjects and methods: The spinal cord (SC) levels of adrenaline (A), noradrenaline (NA), and dopamine (DA) were studied in albino male rats of five age groups: 1) neonatal...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2007-08-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/979 |
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| author | V. G. Ovsyannikov A. V. Kapliyev |
| author_facet | V. G. Ovsyannikov A. V. Kapliyev |
| author_sort | V. G. Ovsyannikov |
| collection | DOAJ |
| description | Objective: to study the age-related features of an adrenergic response of the central nervous system to acute somatic pain (ASP).Subjects and methods: The spinal cord (SC) levels of adrenaline (A), noradrenaline (NA), and dopamine (DA) were studied in albino male rats of five age groups: 1) neonatal (2—4-day) rats; 2) 17—18-day rats that began to see; 3) monthly rats; 4) sexually mature (3—4 month) ones; and 5) old ones aged over 2 years. ASP was reproduced by electrodermal stimulation of the rat tail; the levels of catecholamines (CA) were measured by spectrofluorimetric microassay.Results. During postnatal ontogenesis, the rats were found to have a phase pattern of physiological changes in the spinal concentrations of CA: a decrease in their high neonatal levels (due to DA) by the time the animals began to see; their progressive increase by prepuberty (due to NA) and in sexually maturity (due to A and DA), and a reduction in all CA fractions in old rats. ASP was attended by a rise in the SC concentration of CA in the neonatal animals and by clearly-cut reactive shifts in all fractions in the old ones. With A and DA increases, the SC concentrations of NA halved in the rats that began to see and had ASP; the amount of CA remained unchanged as compared with the controls. In prepubertal and sexually mature male rats, there was a reduction in the spinal CA pool, but due to different components: to A and NA in 35-day rats and to A and DA in 3-month ones.Conclusion. Age-related changes in the pattern of a spinal CA response in rats with ASP show a ontogenetic trend in the development of adrenal responsiveness from the immature generalized forms of an early postnatal period to the definitive differentiated economic reactions of the hypo-to-normergic type and then to the hyperergic destructive reactions of old age. |
| first_indexed | 2024-04-10T01:31:02Z |
| format | Article |
| id | doaj.art-ef353f9e06a94a86bd9698dbd162d147 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:31:02Z |
| publishDate | 2007-08-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-ef353f9e06a94a86bd9698dbd162d1472023-03-13T09:32:47ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102007-08-013411011310.15360/1813-9779-2007-4-110-113979Age-Related Features of Reactive Catecholamine Shifts in the Spinal Cord in Acute Somatic Pain: Experimental StudyV. G. Ovsyannikov0A. V. Kapliyev1Ростовский государственный медицинский университетРостовский государственный медицинский университетObjective: to study the age-related features of an adrenergic response of the central nervous system to acute somatic pain (ASP).Subjects and methods: The spinal cord (SC) levels of adrenaline (A), noradrenaline (NA), and dopamine (DA) were studied in albino male rats of five age groups: 1) neonatal (2—4-day) rats; 2) 17—18-day rats that began to see; 3) monthly rats; 4) sexually mature (3—4 month) ones; and 5) old ones aged over 2 years. ASP was reproduced by electrodermal stimulation of the rat tail; the levels of catecholamines (CA) were measured by spectrofluorimetric microassay.Results. During postnatal ontogenesis, the rats were found to have a phase pattern of physiological changes in the spinal concentrations of CA: a decrease in their high neonatal levels (due to DA) by the time the animals began to see; their progressive increase by prepuberty (due to NA) and in sexually maturity (due to A and DA), and a reduction in all CA fractions in old rats. ASP was attended by a rise in the SC concentration of CA in the neonatal animals and by clearly-cut reactive shifts in all fractions in the old ones. With A and DA increases, the SC concentrations of NA halved in the rats that began to see and had ASP; the amount of CA remained unchanged as compared with the controls. In prepubertal and sexually mature male rats, there was a reduction in the spinal CA pool, but due to different components: to A and NA in 35-day rats and to A and DA in 3-month ones.Conclusion. Age-related changes in the pattern of a spinal CA response in rats with ASP show a ontogenetic trend in the development of adrenal responsiveness from the immature generalized forms of an early postnatal period to the definitive differentiated economic reactions of the hypo-to-normergic type and then to the hyperergic destructive reactions of old age.https://www.reanimatology.com/rmt/article/view/979катехоламиныбольспинной мозгонтогенез |
| spellingShingle | V. G. Ovsyannikov A. V. Kapliyev Age-Related Features of Reactive Catecholamine Shifts in the Spinal Cord in Acute Somatic Pain: Experimental Study Общая реаниматология катехоламины боль спинной мозг онтогенез |
| title | Age-Related Features of Reactive Catecholamine Shifts in the Spinal Cord in Acute Somatic Pain: Experimental Study |
| title_full | Age-Related Features of Reactive Catecholamine Shifts in the Spinal Cord in Acute Somatic Pain: Experimental Study |
| title_fullStr | Age-Related Features of Reactive Catecholamine Shifts in the Spinal Cord in Acute Somatic Pain: Experimental Study |
| title_full_unstemmed | Age-Related Features of Reactive Catecholamine Shifts in the Spinal Cord in Acute Somatic Pain: Experimental Study |
| title_short | Age-Related Features of Reactive Catecholamine Shifts in the Spinal Cord in Acute Somatic Pain: Experimental Study |
| title_sort | age related features of reactive catecholamine shifts in the spinal cord in acute somatic pain experimental study |
| topic | катехоламины боль спинной мозг онтогенез |
| url | https://www.reanimatology.com/rmt/article/view/979 |
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