Anti-Cancer and Ototoxicity Characteristics of the Curcuminoids, CLEFMA and EF24, in Combination with Cisplatin

Anti-Cancer and Ototoxicity Characteristics of the Curcuminoids, CLEFMA and EF24, in Combination with Cisplatin

In this study, we investigated whether the curcuminoids, CLEFMA and EF24, improved cisplatin efficacy and reduced cisplatin ototoxicity. We used the lung cancer cell line, A549, to determine the effects of the curcuminoids and cisplatin on cell viability and several apoptotic signaling mechanisms. C...

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Bibliographic Details
Main Authors: Jerry D. Monroe, Denis Hodzic, Matthew H. Millay, Blaine G. Patty, Michael E. Smith
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
cancer
curcuminoid
cisplatin
zebrafish
reactive oxygen species
auditory evoked potential
apoptosis
cell migration
Online Access:https://www.mdpi.com/1420-3049/24/21/3889

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