miR-376a Provokes Rectum Adenocarcinoma Via CTC1 Depletion-Induced Telomere Dysfunction

miR-376a Provokes Rectum Adenocarcinoma Via CTC1 Depletion-Induced Telomere Dysfunction

CTC1 is a component of the mammalian CST (CTC1–STN1–TEN1) complex which plays essential roles in resolving replication problems to facilitate telomeric DNA and genomic DNA replication. We previously reported that the depletion of CTC1 leads to stalled replication fork restart defects. Moreover, the...

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Bibliographic Details
Main Authors: Yang Liu, Xiaotong Zhao, Bing Wang, Zhijia Liu, Manman Zhang, Jinhan Wang, Chang Xu, Yan Wang, Liqing Du, Feng Wang, Qin Wang, Qiang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CST
telomere
rectum adenocarcinoma
miR-376a
microRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.649328/full

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