Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.
<h4>Background</h4>The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation.<h4>Methods</h4>We systematically searched electronic databases to identify articles reporting the i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0259288 |
| _version_ | 1819007115517231104 |
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| author | Yukinori Takenaka Norihiko Takemoto Ryohei Oya Hidenori Inohara |
| author_facet | Yukinori Takenaka Norihiko Takemoto Ryohei Oya Hidenori Inohara |
| author_sort | Yukinori Takenaka |
| collection | DOAJ |
| description | <h4>Background</h4>The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation.<h4>Methods</h4>We systematically searched electronic databases to identify articles reporting the impact of sarcopenia on the prognosis of patients with HNC. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) were extracted and pooled. HR according to treatment modality were estimated using random-effects models. Statistical analyses were carried out using the Comprehensive Meta-Analysis software.<h4>Results</h4>In total, 18 studies enrolling 3,233 patients were included. Sarcopenia was associated with poor OS in both surgery and radiotherapy groups (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.95-3.21; HR 1.63, 95% CI 1.40-1.90, respectively). The HR was significantly higher in the surgery group than in the radiotherapy group (p = 0.004), with similar results obtained for DFS (HR 2.59, 95% CI 1.56-4.31; HR 1.56, 95% CI 1.24-1.97 for the surgery and radiotherapy groups, respectively) and DSS (HR 2.96, 95% CI 0.73-11.95; HR 2.67, 95% CI 1.51-4.73 for the surgery and RT groups, respectively).<h4>Conclusions</h4>Sarcopenia was a poor prognostic factor for HNC, regardless of the treatment modality. However, the adverse effects of sarcopenia on survival were more prominent in the surgery group than in the radiotherapy group. Sarcopenia assessment is required for appropriate treatment decision-making. |
| first_indexed | 2024-12-21T00:19:27Z |
| format | Article |
| id | doaj.art-ef38580d3b074966be8808f9d64def6e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T00:19:27Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ef38580d3b074966be8808f9d64def6e2022-12-21T19:22:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011610e025928810.1371/journal.pone.0259288Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.Yukinori TakenakaNorihiko TakemotoRyohei OyaHidenori Inohara<h4>Background</h4>The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation.<h4>Methods</h4>We systematically searched electronic databases to identify articles reporting the impact of sarcopenia on the prognosis of patients with HNC. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) were extracted and pooled. HR according to treatment modality were estimated using random-effects models. Statistical analyses were carried out using the Comprehensive Meta-Analysis software.<h4>Results</h4>In total, 18 studies enrolling 3,233 patients were included. Sarcopenia was associated with poor OS in both surgery and radiotherapy groups (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.95-3.21; HR 1.63, 95% CI 1.40-1.90, respectively). The HR was significantly higher in the surgery group than in the radiotherapy group (p = 0.004), with similar results obtained for DFS (HR 2.59, 95% CI 1.56-4.31; HR 1.56, 95% CI 1.24-1.97 for the surgery and radiotherapy groups, respectively) and DSS (HR 2.96, 95% CI 0.73-11.95; HR 2.67, 95% CI 1.51-4.73 for the surgery and RT groups, respectively).<h4>Conclusions</h4>Sarcopenia was a poor prognostic factor for HNC, regardless of the treatment modality. However, the adverse effects of sarcopenia on survival were more prominent in the surgery group than in the radiotherapy group. Sarcopenia assessment is required for appropriate treatment decision-making.https://doi.org/10.1371/journal.pone.0259288 |
| spellingShingle | Yukinori Takenaka Norihiko Takemoto Ryohei Oya Hidenori Inohara Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis. PLoS ONE |
| title | Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis. |
| title_full | Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis. |
| title_fullStr | Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis. |
| title_full_unstemmed | Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis. |
| title_short | Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis. |
| title_sort | prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation a meta analysis |
| url | https://doi.org/10.1371/journal.pone.0259288 |
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