The Role of MSCs and Cell Fusion in Tissue Regeneration
Regenerative medicine is concerned with the investigation of therapeutic agents that can be used to promote the process of regeneration after injury or in different diseases. Mesenchymal stem/stromal cells (MSCs) and their secretome—including extracellular vesicles (EVs) are of great interest, due t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/20/10980 |
| _version_ | 1797514413862813696 |
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| author | Jessica Dörnen Thomas Dittmar |
| author_facet | Jessica Dörnen Thomas Dittmar |
| author_sort | Jessica Dörnen |
| collection | DOAJ |
| description | Regenerative medicine is concerned with the investigation of therapeutic agents that can be used to promote the process of regeneration after injury or in different diseases. Mesenchymal stem/stromal cells (MSCs) and their secretome—including extracellular vesicles (EVs) are of great interest, due to their role in tissue regeneration, immunomodulatory capacity and low immunogenicity. So far, clinical studies are not very conclusive as they show conflicting efficacies regarding the use of MSCs. An additional process possibly involved in regeneration might be cell fusion. This process occurs in both a physiological and a pathophysiological context and can be affected by immune response due to inflammation. In this review the role of MSCs and cell fusion in tissue regeneration is discussed. |
| first_indexed | 2024-03-10T06:31:17Z |
| format | Article |
| id | doaj.art-ef3a8f192b3b4eaf870ad302aa0083a4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:31:17Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ef3a8f192b3b4eaf870ad302aa0083a42023-11-22T18:31:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122201098010.3390/ijms222010980The Role of MSCs and Cell Fusion in Tissue RegenerationJessica Dörnen0Thomas Dittmar1Institute of Immunology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Str. 10, 58448 Witten, GermanyInstitute of Immunology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Str. 10, 58448 Witten, GermanyRegenerative medicine is concerned with the investigation of therapeutic agents that can be used to promote the process of regeneration after injury or in different diseases. Mesenchymal stem/stromal cells (MSCs) and their secretome—including extracellular vesicles (EVs) are of great interest, due to their role in tissue regeneration, immunomodulatory capacity and low immunogenicity. So far, clinical studies are not very conclusive as they show conflicting efficacies regarding the use of MSCs. An additional process possibly involved in regeneration might be cell fusion. This process occurs in both a physiological and a pathophysiological context and can be affected by immune response due to inflammation. In this review the role of MSCs and cell fusion in tissue regeneration is discussed.https://www.mdpi.com/1422-0067/22/20/10980tissue regenerationcell fusionmesenchymal stem/progenitor cells |
| spellingShingle | Jessica Dörnen Thomas Dittmar The Role of MSCs and Cell Fusion in Tissue Regeneration International Journal of Molecular Sciences tissue regeneration cell fusion mesenchymal stem/progenitor cells |
| title | The Role of MSCs and Cell Fusion in Tissue Regeneration |
| title_full | The Role of MSCs and Cell Fusion in Tissue Regeneration |
| title_fullStr | The Role of MSCs and Cell Fusion in Tissue Regeneration |
| title_full_unstemmed | The Role of MSCs and Cell Fusion in Tissue Regeneration |
| title_short | The Role of MSCs and Cell Fusion in Tissue Regeneration |
| title_sort | role of mscs and cell fusion in tissue regeneration |
| topic | tissue regeneration cell fusion mesenchymal stem/progenitor cells |
| url | https://www.mdpi.com/1422-0067/22/20/10980 |
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