One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study
Immune activation in HIV-1-infected individuals is reduced under antiretroviral therapies, but persists, resulting in various morbidities. To better characterize this phenomenon, using a panel of 68 soluble and cell surface markers, we measured the level of activation in circulating CD4+ and CD8+ T...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-06-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396416301918 |
| _version_ | 1828530841026822144 |
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| author | Christina Psomas Mehwish Younas Christelle Reynes Renaud Cezar Pierre Portalès Edouard Tuaillon Adeline Guigues Corinne Merle Nadine Atoui Céline Fernandez Vincent Le Moing Claudine Barbuat Grégory Marin Nicolas Nagot Albert Sotto Jean-François Eliaou Robert Sabatier Jacques Reynes Pierre Corbeau |
| author_facet | Christina Psomas Mehwish Younas Christelle Reynes Renaud Cezar Pierre Portalès Edouard Tuaillon Adeline Guigues Corinne Merle Nadine Atoui Céline Fernandez Vincent Le Moing Claudine Barbuat Grégory Marin Nicolas Nagot Albert Sotto Jean-François Eliaou Robert Sabatier Jacques Reynes Pierre Corbeau |
| author_sort | Christina Psomas |
| collection | DOAJ |
| description | Immune activation in HIV-1-infected individuals is reduced under antiretroviral therapies, but persists, resulting in various morbidities. To better characterize this phenomenon, using a panel of 68 soluble and cell surface markers, we measured the level of activation in circulating CD4+ and CD8+ T cells, B cells, monocytes, NK cells, polynuclear and endothelial cells as well as of inflammation and fibrinolysis in 120 virologic responders over 45 years of age. As compared with age- and sex-matched uninfected individuals, we observed a persistence of activation in all the cell subpopulations analyzed, together with marks of inflammation and fibrinolysis. Two independent hierarchical clustering analyses allowed us to identify five clusters of markers that varied concurrently, and five patient groups, each with the same activation profile. The five groups of patients could be characterized by a marker of CD4+ T cell, CD8+ T cell, NK cell, monocyte activation or of inflammation, respectively. One of these profiles was strongly associated with marks of metabolic syndrome, particularly with hyperinsulinemia (OR 12.17 [95% CI 1.79–82.86], p = 0.011). In conclusion, our study unveils biomarkers linked to metabolic syndrome that could be tested as predictive markers, and opens the way to new therapeutic approaches tailored to each patient group. |
| first_indexed | 2024-12-11T22:29:01Z |
| format | Article |
| id | doaj.art-ef3beccf731a47929b3962937d9df2ae |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-11T22:29:01Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-ef3beccf731a47929b3962937d9df2ae2022-12-22T00:48:12ZengElsevierEBioMedicine2352-39642016-06-018C26527610.1016/j.ebiom.2016.05.008One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH studyChristina Psomas0Mehwish Younas1Christelle Reynes2Renaud Cezar3Pierre Portalès4Edouard Tuaillon5Adeline Guigues6Corinne Merle7Nadine Atoui8Céline Fernandez9Vincent Le Moing10Claudine Barbuat11Grégory Marin12Nicolas Nagot13Albert Sotto14Jean-François Eliaou15Robert Sabatier16Jacques Reynes17Pierre Corbeau18Institute for Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, 34396, Montpellier cedex 5, FranceInstitute for Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, 34396, Montpellier cedex 5, FranceInstitute for Functional Genomics, Montpellier University, UMR5203, 141 rue de la Cardonille, 34396 Montpellier cedex 5, FranceImmunology Department, University Hospital, Place du Pr Debré, 30029 Nîmes cedex, FranceImmunology Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, FranceMicrobiology Department, University Hospital, 371 Av. du Doyen Gaston Giraud, 34295 Montpellier cedex 5, FranceInstitute for Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, 34396, Montpellier cedex 5, FranceInfectious Diseases Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, FranceInfectious Diseases Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, FranceInfectious Diseases Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, FranceInfectious Diseases Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, FranceInfectious Diseases Department, University Hospital, Place du Pr Debré, 30029 Nîmes cedex, FranceMedical Informatics Department, University Hospital, 39 Avenue Charles Flahault, 34090 Montpellier cedex 5, FranceMedical Informatics Department, University Hospital, 39 Avenue Charles Flahault, 34090 Montpellier cedex 5, FranceMontpellier University, 5 Boulevard Henri IV, 34967 Montpellier cedex 2, FranceImmunology Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, FranceInstitute for Functional Genomics, Montpellier University, UMR5203, 141 rue de la Cardonille, 34396 Montpellier cedex 5, FranceInfectious Diseases Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, FranceInstitute for Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, 34396, Montpellier cedex 5, FranceImmune activation in HIV-1-infected individuals is reduced under antiretroviral therapies, but persists, resulting in various morbidities. To better characterize this phenomenon, using a panel of 68 soluble and cell surface markers, we measured the level of activation in circulating CD4+ and CD8+ T cells, B cells, monocytes, NK cells, polynuclear and endothelial cells as well as of inflammation and fibrinolysis in 120 virologic responders over 45 years of age. As compared with age- and sex-matched uninfected individuals, we observed a persistence of activation in all the cell subpopulations analyzed, together with marks of inflammation and fibrinolysis. Two independent hierarchical clustering analyses allowed us to identify five clusters of markers that varied concurrently, and five patient groups, each with the same activation profile. The five groups of patients could be characterized by a marker of CD4+ T cell, CD8+ T cell, NK cell, monocyte activation or of inflammation, respectively. One of these profiles was strongly associated with marks of metabolic syndrome, particularly with hyperinsulinemia (OR 12.17 [95% CI 1.79–82.86], p = 0.011). In conclusion, our study unveils biomarkers linked to metabolic syndrome that could be tested as predictive markers, and opens the way to new therapeutic approaches tailored to each patient group.http://www.sciencedirect.com/science/article/pii/S2352396416301918HyperinsulinemiaCell activationInflammationCoagulationEndothelium |
| spellingShingle | Christina Psomas Mehwish Younas Christelle Reynes Renaud Cezar Pierre Portalès Edouard Tuaillon Adeline Guigues Corinne Merle Nadine Atoui Céline Fernandez Vincent Le Moing Claudine Barbuat Grégory Marin Nicolas Nagot Albert Sotto Jean-François Eliaou Robert Sabatier Jacques Reynes Pierre Corbeau One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study EBioMedicine Hyperinsulinemia Cell activation Inflammation Coagulation Endothelium |
| title | One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study |
| title_full | One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study |
| title_fullStr | One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study |
| title_full_unstemmed | One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study |
| title_short | One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study |
| title_sort | one of the immune activation profiles observed in hiv 1 infected adults with suppressed viremia is linked to metabolic syndrome the activih study |
| topic | Hyperinsulinemia Cell activation Inflammation Coagulation Endothelium |
| url | http://www.sciencedirect.com/science/article/pii/S2352396416301918 |
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