Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold

Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold

Abstract Background and aims This study sought to determine the value of patient-derived organoids (PDOs) from esophago-gastric adenocarcinoma (EGC) for response prediction to neoadjuvant chemotherapy (neoCTx). Methods Endoscopic biopsies of patients with locally advanced EGC (n = 120) were taken in...

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Main Authors: Tim Schmäche, Juliane Fohgrub, Anna Klimova, Karin Laaber, Stephan Drukewitz, Felix Merboth, Alexander Hennig, Therese Seidlitz, Friederike Herbst, Franziska Baenke, Anne-Marlen Ada, Thomas Groß, Carina Wenzel, Claudia R. Ball, Christian Praetorius, Thomas Schmidt, Barbara Ringelband-Schilling, Ronald Koschny, Albrecht Stenzinger, Ingo Roeder, Dirk Jaeger, Sebastian Zeissig, Thilo Welsch, Daniela Aust, Hanno Glimm, Gunnar Folprecht, Jürgen Weitz, Georg M. Haag, Daniel E. Stange
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Molecular Cancer
Subjects:
Gastric cancer
Personalized medicine
Patient-derived organoids
Response prediction
Online Access:https://doi.org/10.1186/s12943-023-01919-3

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