Vaginal Microbiome in Reproductive Medicine
The human microbiome has been given increasing importance in recent years. The establishment of sequencing-based technology has made it possible to identify a large number of bacterial species that were previously beyond the scope of culture-based technologies. Just as microbiome diagnostics has eme...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/8/1948 |
| _version_ | 1797446047882018816 |
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| author | Veronika Günther Leila Allahqoli Rafal Watrowski Nicolai Maass Johannes Ackermann Sören von Otte Ibrahim Alkatout |
| author_facet | Veronika Günther Leila Allahqoli Rafal Watrowski Nicolai Maass Johannes Ackermann Sören von Otte Ibrahim Alkatout |
| author_sort | Veronika Günther |
| collection | DOAJ |
| description | The human microbiome has been given increasing importance in recent years. The establishment of sequencing-based technology has made it possible to identify a large number of bacterial species that were previously beyond the scope of culture-based technologies. Just as microbiome diagnostics has emerged as a major point of focus in science, reproductive medicine has developed into a subject of avid interest, particularly with regard to causal research and treatment options for implantation failure. Thus, the vaginal microbiome is discussed as a factor influencing infertility and a promising target for treatment options. The present review provides an overview of current research concerning the impact of the vaginal microbiome on the outcome of reproductive measures. A non-<i>Lactobacillus</i>-dominated microbiome was shown to be associated with dysbiosis, possibly even bacterial vaginosis. This imbalance has a negative impact on implantation rates in assisted reproductive technologies and may also be responsible for habitual abortions. Screening of the microbiome in conjunction with antibiotic and/or probiotic treatment appears to be one way of improving pregnancy outcomes. |
| first_indexed | 2024-03-09T13:35:35Z |
| format | Article |
| id | doaj.art-ef3d68367a7248788f73055e56a6a341 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T13:35:35Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-ef3d68367a7248788f73055e56a6a3412023-11-30T21:13:38ZengMDPI AGDiagnostics2075-44182022-08-01128194810.3390/diagnostics12081948Vaginal Microbiome in Reproductive MedicineVeronika Günther0Leila Allahqoli1Rafal Watrowski2Nicolai Maass3Johannes Ackermann4Sören von Otte5Ibrahim Alkatout6Department of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3 (House C), 24105 Kiel, GermanySchool of Public Health, Iran University of Medical Sciences (IUMS), Tehran 14535, IranFaculty of Medicine (Faculty Associate), University of Freiburg, 79104 Freiburg, GermanyDepartment of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3 (House C), 24105 Kiel, GermanyDepartment of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3 (House C), 24105 Kiel, GermanyUniversity Fertility Center, Ambulanzzentrum des UKSH gGmbH, Arnold-Heller-Straße 3 (House C), 24105 Kiel, GermanyDepartment of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3 (House C), 24105 Kiel, GermanyThe human microbiome has been given increasing importance in recent years. The establishment of sequencing-based technology has made it possible to identify a large number of bacterial species that were previously beyond the scope of culture-based technologies. Just as microbiome diagnostics has emerged as a major point of focus in science, reproductive medicine has developed into a subject of avid interest, particularly with regard to causal research and treatment options for implantation failure. Thus, the vaginal microbiome is discussed as a factor influencing infertility and a promising target for treatment options. The present review provides an overview of current research concerning the impact of the vaginal microbiome on the outcome of reproductive measures. A non-<i>Lactobacillus</i>-dominated microbiome was shown to be associated with dysbiosis, possibly even bacterial vaginosis. This imbalance has a negative impact on implantation rates in assisted reproductive technologies and may also be responsible for habitual abortions. Screening of the microbiome in conjunction with antibiotic and/or probiotic treatment appears to be one way of improving pregnancy outcomes.https://www.mdpi.com/2075-4418/12/8/1948assisted reproductive technologiesmicrobiomeimplantation failuredysbiosispregnancy |
| spellingShingle | Veronika Günther Leila Allahqoli Rafal Watrowski Nicolai Maass Johannes Ackermann Sören von Otte Ibrahim Alkatout Vaginal Microbiome in Reproductive Medicine Diagnostics assisted reproductive technologies microbiome implantation failure dysbiosis pregnancy |
| title | Vaginal Microbiome in Reproductive Medicine |
| title_full | Vaginal Microbiome in Reproductive Medicine |
| title_fullStr | Vaginal Microbiome in Reproductive Medicine |
| title_full_unstemmed | Vaginal Microbiome in Reproductive Medicine |
| title_short | Vaginal Microbiome in Reproductive Medicine |
| title_sort | vaginal microbiome in reproductive medicine |
| topic | assisted reproductive technologies microbiome implantation failure dysbiosis pregnancy |
| url | https://www.mdpi.com/2075-4418/12/8/1948 |
| work_keys_str_mv | AT veronikagunther vaginalmicrobiomeinreproductivemedicine AT leilaallahqoli vaginalmicrobiomeinreproductivemedicine AT rafalwatrowski vaginalmicrobiomeinreproductivemedicine AT nicolaimaass vaginalmicrobiomeinreproductivemedicine AT johannesackermann vaginalmicrobiomeinreproductivemedicine AT sorenvonotte vaginalmicrobiomeinreproductivemedicine AT ibrahimalkatout vaginalmicrobiomeinreproductivemedicine |