Maturation of metabolic connectivity of the adolescent rat brain
Neuroimaging has been used to examine developmental changes of the brain. While PET studies revealed maturation-related changes, maturation of metabolic connectivity of the brain is not yet understood. Here, we show that rat brain metabolism is reconfigured to achieve long-distance connections with...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/11571 |
| _version_ | 1811236848122462208 |
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| author | Hongyoon Choi Yoori Choi Kyu Wan Kim Hyejin Kang Do Won Hwang E Edmund Kim June-Key Chung Dong Soo Lee |
| author_facet | Hongyoon Choi Yoori Choi Kyu Wan Kim Hyejin Kang Do Won Hwang E Edmund Kim June-Key Chung Dong Soo Lee |
| author_sort | Hongyoon Choi |
| collection | DOAJ |
| description | Neuroimaging has been used to examine developmental changes of the brain. While PET studies revealed maturation-related changes, maturation of metabolic connectivity of the brain is not yet understood. Here, we show that rat brain metabolism is reconfigured to achieve long-distance connections with higher energy efficiency during maturation. Metabolism increased in anterior cerebrum and decreased in thalamus and cerebellum during maturation. When functional covariance patterns of PET images were examined, metabolic networks including default mode network (DMN) were extracted. Connectivity increased between the anterior and posterior parts of DMN and sensory-motor cortices during maturation. Energy efficiency, a ratio of connectivity strength to metabolism of a region, increased in medial prefrontal and retrosplenial cortices. Our data revealed that metabolic networks mature to increase metabolic connections and establish its efficiency between large-scale spatial components from childhood to early adulthood. Neurodevelopmental diseases might be understood by abnormal reconfiguration of metabolic connectivity and efficiency. |
| first_indexed | 2024-04-12T12:16:13Z |
| format | Article |
| id | doaj.art-ef40e0e4b5ef4eda82b5ceb4d76e89b0 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:16:13Z |
| publishDate | 2015-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ef40e0e4b5ef4eda82b5ceb4d76e89b02022-12-22T03:33:26ZengeLife Sciences Publications LtdeLife2050-084X2015-11-01410.7554/eLife.11571Maturation of metabolic connectivity of the adolescent rat brainHongyoon Choi0Yoori Choi1Kyu Wan Kim2Hyejin Kang3Do Won Hwang4E Edmund Kim5June-Key Chung6Dong Soo Lee7Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of KoreaDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of KoreaDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of KoreaDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of KoreaNeuroimaging has been used to examine developmental changes of the brain. While PET studies revealed maturation-related changes, maturation of metabolic connectivity of the brain is not yet understood. Here, we show that rat brain metabolism is reconfigured to achieve long-distance connections with higher energy efficiency during maturation. Metabolism increased in anterior cerebrum and decreased in thalamus and cerebellum during maturation. When functional covariance patterns of PET images were examined, metabolic networks including default mode network (DMN) were extracted. Connectivity increased between the anterior and posterior parts of DMN and sensory-motor cortices during maturation. Energy efficiency, a ratio of connectivity strength to metabolism of a region, increased in medial prefrontal and retrosplenial cortices. Our data revealed that metabolic networks mature to increase metabolic connections and establish its efficiency between large-scale spatial components from childhood to early adulthood. Neurodevelopmental diseases might be understood by abnormal reconfiguration of metabolic connectivity and efficiency.https://elifesciences.org/articles/11571FDG PETmetabolic connectivitybrain maturationresting-state networkadolescentenergy efficiency |
| spellingShingle | Hongyoon Choi Yoori Choi Kyu Wan Kim Hyejin Kang Do Won Hwang E Edmund Kim June-Key Chung Dong Soo Lee Maturation of metabolic connectivity of the adolescent rat brain eLife FDG PET metabolic connectivity brain maturation resting-state network adolescent energy efficiency |
| title | Maturation of metabolic connectivity of the adolescent rat brain |
| title_full | Maturation of metabolic connectivity of the adolescent rat brain |
| title_fullStr | Maturation of metabolic connectivity of the adolescent rat brain |
| title_full_unstemmed | Maturation of metabolic connectivity of the adolescent rat brain |
| title_short | Maturation of metabolic connectivity of the adolescent rat brain |
| title_sort | maturation of metabolic connectivity of the adolescent rat brain |
| topic | FDG PET metabolic connectivity brain maturation resting-state network adolescent energy efficiency |
| url | https://elifesciences.org/articles/11571 |
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