Diallyl trisulfide (DATS) ameliorates cardiac fibrosis in a rat model of diabetes
Cardiac fibrosis is a prevalent pathological complication observed in individuals with diabetes. Diallyl trisulfide (DATS), a bioactive compound found in garlic oil, has been reported to exhibit anti-inflammatory and anti-apoptotic effects in various cardiovascular diseases. However, its potential i...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623005017 |
| _version_ | 1827620857986416640 |
|---|---|
| author | Dennis Jine-Yuan Hsieh Shang-Chuan Ng Shang-Yeh Lu Yen-Tun Chiu Kuan-Ho Lin Yueh-Min Lin Chih-Yang Huang Wei-Wen Kuo |
| author_facet | Dennis Jine-Yuan Hsieh Shang-Chuan Ng Shang-Yeh Lu Yen-Tun Chiu Kuan-Ho Lin Yueh-Min Lin Chih-Yang Huang Wei-Wen Kuo |
| author_sort | Dennis Jine-Yuan Hsieh |
| collection | DOAJ |
| description | Cardiac fibrosis is a prevalent pathological complication observed in individuals with diabetes. Diallyl trisulfide (DATS), a bioactive compound found in garlic oil, has been reported to exhibit anti-inflammatory and anti-apoptotic effects in various cardiovascular diseases. However, its potential impact on cardiac fibrosis, particularly in the context of diabetes, remains unknown. In the neonatal rat ventricular fibroblasts (NRVFs) model, our results demonstrated that DATS effectively attenuated advanced glycation end products (AGEs)-induced activation of Nuclear factor kappa B (NF-κB) and Smad2/3 signaling pathways, leading to a reduction in the downstream secretion of pro-inflammatory cytokines and collagen synthesis. In the in vivo study using echocardiographic assessment, administration of DATS significantly ameliorated cardiac dysfunction induced by streptozotocin (STZ). Taken together, our findings highlight the potential of DATS as a promising therapeutic agent for mitigating cardiac fibrosis associated with diabetes, emphasizing its potential clinical relevance in the prevention and management of diabetic cardiomyopathy. |
| first_indexed | 2024-03-09T10:53:51Z |
| format | Article |
| id | doaj.art-ef4172a961aa40c1929b02fe526943eb |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-09T10:53:51Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ef4172a961aa40c1929b02fe526943eb2023-12-01T05:01:14ZengElsevierJournal of Functional Foods1756-46462023-12-01111105901Diallyl trisulfide (DATS) ameliorates cardiac fibrosis in a rat model of diabetesDennis Jine-Yuan Hsieh0Shang-Chuan Ng1Shang-Yeh Lu2Yen-Tun Chiu3Kuan-Ho Lin4Yueh-Min Lin5Chih-Yang Huang6Wei-Wen Kuo7School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan, ROC; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan, ROCDepartment of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung 406, Taiwan, ROC; Ph.D. Program for Biotechnology Industry, China Medical University, Taichung 406, Taiwan, ROCDivision of Cardiovascular Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung 404, Taiwan, ROC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROCDepartment of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung 406, Taiwan, ROC; Ph.D. Program for Biotechnology Industry, China Medical University, Taichung 406, Taiwan, ROCCollege of Medicine, China Medical University, Taichung 404, Taiwan, ROC; Department of Emergency Medicine, China Medical University Hospital, Taichung 404, Taiwan, ROCDepartment of Surgical Pathology, Changhua Christian Hospital, Changhua 500, Taiwan, ROC; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan, ROC; Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan, ROCGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROC; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan, ROC; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien 970, Taiwan, ROC; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan, ROC; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 413, Taiwan, ROCDepartment of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung 406, Taiwan, ROC; Ph.D. Program for Biotechnology Industry, China Medical University, Taichung 406, Taiwan, ROC; Corresponding author at: Dept. of Biological Science & Technology, School of Life Science, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan, ROC (W.-W. Kuo).Cardiac fibrosis is a prevalent pathological complication observed in individuals with diabetes. Diallyl trisulfide (DATS), a bioactive compound found in garlic oil, has been reported to exhibit anti-inflammatory and anti-apoptotic effects in various cardiovascular diseases. However, its potential impact on cardiac fibrosis, particularly in the context of diabetes, remains unknown. In the neonatal rat ventricular fibroblasts (NRVFs) model, our results demonstrated that DATS effectively attenuated advanced glycation end products (AGEs)-induced activation of Nuclear factor kappa B (NF-κB) and Smad2/3 signaling pathways, leading to a reduction in the downstream secretion of pro-inflammatory cytokines and collagen synthesis. In the in vivo study using echocardiographic assessment, administration of DATS significantly ameliorated cardiac dysfunction induced by streptozotocin (STZ). Taken together, our findings highlight the potential of DATS as a promising therapeutic agent for mitigating cardiac fibrosis associated with diabetes, emphasizing its potential clinical relevance in the prevention and management of diabetic cardiomyopathy.http://www.sciencedirect.com/science/article/pii/S1756464623005017Diallyl trisulfide (DATS)FibrosisDiabetic mellitus (Hsieh et al.)NFκBSmad2/3 |
| spellingShingle | Dennis Jine-Yuan Hsieh Shang-Chuan Ng Shang-Yeh Lu Yen-Tun Chiu Kuan-Ho Lin Yueh-Min Lin Chih-Yang Huang Wei-Wen Kuo Diallyl trisulfide (DATS) ameliorates cardiac fibrosis in a rat model of diabetes Journal of Functional Foods Diallyl trisulfide (DATS) Fibrosis Diabetic mellitus (Hsieh et al.) NFκB Smad2/3 |
| title | Diallyl trisulfide (DATS) ameliorates cardiac fibrosis in a rat model of diabetes |
| title_full | Diallyl trisulfide (DATS) ameliorates cardiac fibrosis in a rat model of diabetes |
| title_fullStr | Diallyl trisulfide (DATS) ameliorates cardiac fibrosis in a rat model of diabetes |
| title_full_unstemmed | Diallyl trisulfide (DATS) ameliorates cardiac fibrosis in a rat model of diabetes |
| title_short | Diallyl trisulfide (DATS) ameliorates cardiac fibrosis in a rat model of diabetes |
| title_sort | diallyl trisulfide dats ameliorates cardiac fibrosis in a rat model of diabetes |
| topic | Diallyl trisulfide (DATS) Fibrosis Diabetic mellitus (Hsieh et al.) NFκB Smad2/3 |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623005017 |
| work_keys_str_mv | AT dennisjineyuanhsieh diallyltrisulfidedatsamelioratescardiacfibrosisinaratmodelofdiabetes AT shangchuanng diallyltrisulfidedatsamelioratescardiacfibrosisinaratmodelofdiabetes AT shangyehlu diallyltrisulfidedatsamelioratescardiacfibrosisinaratmodelofdiabetes AT yentunchiu diallyltrisulfidedatsamelioratescardiacfibrosisinaratmodelofdiabetes AT kuanholin diallyltrisulfidedatsamelioratescardiacfibrosisinaratmodelofdiabetes AT yuehminlin diallyltrisulfidedatsamelioratescardiacfibrosisinaratmodelofdiabetes AT chihyanghuang diallyltrisulfidedatsamelioratescardiacfibrosisinaratmodelofdiabetes AT weiwenkuo diallyltrisulfidedatsamelioratescardiacfibrosisinaratmodelofdiabetes |