A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-<i>a</i>]pyrimidines Molecules
A method for the technically easy-to-implement synthesis of deuterium-labeled pyrazolo[1,5-<i>a</i>]pyrimidines and 1,2,4-triazolo[1,5-<i>a</i>]pyrimidines have been developed. The regioselectivity of such transformations has been shown. <sup>1</sup>H NMR and mass...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/6/2869 |
| Summary: | A method for the technically easy-to-implement synthesis of deuterium-labeled pyrazolo[1,5-<i>a</i>]pyrimidines and 1,2,4-triazolo[1,5-<i>a</i>]pyrimidines have been developed. The regioselectivity of such transformations has been shown. <sup>1</sup>H NMR and mass spectrometric methods have proved the quantitative nature of such transformations and the kinetics of deuterium exchange has been studied. Spectrally, at different temperatures (+30 °C, −10 °C and −15 °C), the kinetics of the process was studied both in CD<sub>3</sub>OD and in deuterated alkali. |
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| ISSN: | 1420-3049 |