Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents
Objective: This study aimed to identify the prevalence of hypertriglyceridemic waist (HTW) phenotype, and to evaluate its association with metabolic abnormalities in adolescents of low socioeconomic status. Method: This was a cross-sectional study with a random sample of 1,076 adolescents between 11...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2013-01-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553613000104 |
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| author | Maria Ester P. da Conceição-Machado Luciana R. Silva Mônica Leila P. Santana Elizabete J. Pinto Rita de Cássia R. Silva Lia Terezinha L.P. Moraes Ricardo D. Couto Ana Marlúcia O. Assis |
| author_facet | Maria Ester P. da Conceição-Machado Luciana R. Silva Mônica Leila P. Santana Elizabete J. Pinto Rita de Cássia R. Silva Lia Terezinha L.P. Moraes Ricardo D. Couto Ana Marlúcia O. Assis |
| author_sort | Maria Ester P. da Conceição-Machado |
| collection | DOAJ |
| description | Objective: This study aimed to identify the prevalence of hypertriglyceridemic waist (HTW) phenotype, and to evaluate its association with metabolic abnormalities in adolescents of low socioeconomic status.
Method: This was a cross-sectional study with a random sample of 1,076 adolescents between 11 and 17 years, of both genders, from public schools. The participants underwent anthropometric measurements (weight, height, and waist circumference), and levels of total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), non-HDL cholesterol, triglyceride (TG), and fasting glucose were measured. Information regarding the socioeconomic status of the participants’ families was obtained. The HTW phenotype was defined by the simultaneous presence of increased waist circumference (≥ 90th percentile for age and gender) and serum triglyceride levels (≥ 100 mg/dL). A logistic regression analysis was used to evaluate the associations of interest.
Results: The prevalence of HTW phenotype was 7.2% among the adolescents, being higher in the presence of obesity (63.4%) and high levels of non-HDL cholesterol (16.6%) and LDL-C (13.7%). The bivariate analysis indicated that, of the metabolic variables, only blood glucose was not associated with the HTW phenotype. Multivariate analysis adjusted for age and gender indicated that the HTW phenotype was positively associated with high non-HDL cholesterol (odds ratio: 7.0; 95% CI: 3.9-12.6) and low HDL-C levels (odds ratio: 2.7; 95% CI: 1.5-4.8).
Conclusions: This study demonstrated that the HTW phenotype was associated with an atherogenic lipid profile, and this phenotype is suggested as a screening tool to identify adolescents with metabolic alterations. |
| first_indexed | 2024-04-12T00:01:11Z |
| format | Article |
| id | doaj.art-ef44face014945068bf3ec941e00a399 |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T00:01:11Z |
| publishDate | 2013-01-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-ef44face014945068bf3ec941e00a3992022-12-22T03:56:14ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362013-01-01891566310.1016/j.jpedp.2012.08.006Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescentsMaria Ester P. da Conceição-Machado0Luciana R. Silva1Mônica Leila P. Santana2Elizabete J. Pinto3Rita de Cássia R. Silva4Lia Terezinha L.P. Moraes5Ricardo D. Couto6Ana Marlúcia O. Assis7PhD Candidate, Postgraduate Program in Medicine and Health, Universidade Federal da Bahia Medical School (FAMED), Salvador, BA, Brazil. Adjunct Professor, Department of Nutritional Science, School of Nutrition, Universidade Federal da Bahia (ENUFBA), Salvador, BA, BrazilFull Professor, Pediatric Gastroenterology, Department of Pediatrics, FAMED, Salvador, BA, Brazil. Chief, Pediatric Gastroenterology and Hepatology Unit, Complexo Hospitalar Universitário Professor Edgard Santos (C-HUPES), Salvador, BA, BrazilPhD, Adjunct Professor, Department of Nutritional Science, ENUFBA, Salvador, BA, BrazilStatistician. MSc, Postgraduate Program in Medicine and Health, FAMED, Salvador, BA, BrazilPost-doctorate. Associate Professor, Postgraduate Program in Food and Nutrition, ENUFBA, Salvador, BA, BrazilProfessor, Department of Statistics, Instituto de Matemática, Universidade Federal da Bahia (UFBA), Salvador, BA, BrazilPost-doctorate. Adjunct Professor, Department of Clinical and Toxicological Analysis, Pharmacy School, UFBA, Salvador, BA, Brazil. Professor Chief, Laboratório Central, C-HUPES, Salvador, BA, BrazilPhD. Full Professor, Postgraduate Program in Food and Nutrition, Department of Nutritional Science, ENUFBA, Salvador, BA, BrazilObjective: This study aimed to identify the prevalence of hypertriglyceridemic waist (HTW) phenotype, and to evaluate its association with metabolic abnormalities in adolescents of low socioeconomic status. Method: This was a cross-sectional study with a random sample of 1,076 adolescents between 11 and 17 years, of both genders, from public schools. The participants underwent anthropometric measurements (weight, height, and waist circumference), and levels of total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), non-HDL cholesterol, triglyceride (TG), and fasting glucose were measured. Information regarding the socioeconomic status of the participants’ families was obtained. The HTW phenotype was defined by the simultaneous presence of increased waist circumference (≥ 90th percentile for age and gender) and serum triglyceride levels (≥ 100 mg/dL). A logistic regression analysis was used to evaluate the associations of interest. Results: The prevalence of HTW phenotype was 7.2% among the adolescents, being higher in the presence of obesity (63.4%) and high levels of non-HDL cholesterol (16.6%) and LDL-C (13.7%). The bivariate analysis indicated that, of the metabolic variables, only blood glucose was not associated with the HTW phenotype. Multivariate analysis adjusted for age and gender indicated that the HTW phenotype was positively associated with high non-HDL cholesterol (odds ratio: 7.0; 95% CI: 3.9-12.6) and low HDL-C levels (odds ratio: 2.7; 95% CI: 1.5-4.8). Conclusions: This study demonstrated that the HTW phenotype was associated with an atherogenic lipid profile, and this phenotype is suggested as a screening tool to identify adolescents with metabolic alterations.http://www.sciencedirect.com/science/article/pii/S2255553613000104Hypertriglyceridemic waistAbdominal obesityHypertriglyceridemiaLipidsAdolescent |
| spellingShingle | Maria Ester P. da Conceição-Machado Luciana R. Silva Mônica Leila P. Santana Elizabete J. Pinto Rita de Cássia R. Silva Lia Terezinha L.P. Moraes Ricardo D. Couto Ana Marlúcia O. Assis Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents Jornal de Pediatria (Versão em Português) Hypertriglyceridemic waist Abdominal obesity Hypertriglyceridemia Lipids Adolescent |
| title | Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents |
| title_full | Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents |
| title_fullStr | Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents |
| title_full_unstemmed | Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents |
| title_short | Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents |
| title_sort | hypertriglyceridemic waist phenotype association with metabolic abnormalities in adolescents |
| topic | Hypertriglyceridemic waist Abdominal obesity Hypertriglyceridemia Lipids Adolescent |
| url | http://www.sciencedirect.com/science/article/pii/S2255553613000104 |
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