Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature review
BackgroundEarly studies have revealed antagonistic effects associated with stacking chemotherapy (CT) and endocrine therapy (ET), thereby conventional wisdom does not advocate the simultaneous combination of these two treatment modalities. Limited clinical studies exist on the combined use of neoadj...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1362725/full |
| _version_ | 1797262476779192320 |
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| author | Nengying Zhang Nengying Zhang Chengmin Luo Jiayang Li Yuxiang Bao Zhongliang Yan Xiaoming Cheng Taolang Li Junyuan Lv Junyuan Lv |
| author_facet | Nengying Zhang Nengying Zhang Chengmin Luo Jiayang Li Yuxiang Bao Zhongliang Yan Xiaoming Cheng Taolang Li Junyuan Lv Junyuan Lv |
| author_sort | Nengying Zhang |
| collection | DOAJ |
| description | BackgroundEarly studies have revealed antagonistic effects associated with stacking chemotherapy (CT) and endocrine therapy (ET), thereby conventional wisdom does not advocate the simultaneous combination of these two treatment modalities. Limited clinical studies exist on the combined use of neoadjuvant CT (NACT) and neoadjuvant ET (NET), and there are no reported instances of concurrent neoadjuvant treatment for locally advanced breast cancer (LABC) using capecitabine and fulvestrant (FUL).Case presentationWe reported a 54-year-old woman who was diagnosed with hormone receptor-positive (HR+) LABC at our hospital. After neoadjuvant treatment involving two distinct CT regimens did not lead to tumor regression. Consequently, the patient was transitioned to concurrent capecitabine and FUL therapy. This change resulted in favorable pathological remission without any significant adverse events during treatment.ConclusionsA novel approach involving concurrent neoadjuvant therapy with CT and endocrine therapy may offer a potentially effective treatment avenue for some cases with HR+ LABC. |
| first_indexed | 2024-04-24T23:57:43Z |
| format | Article |
| id | doaj.art-ef450f0b017445d3963559c01142a6d0 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T23:57:43Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ef450f0b017445d3963559c01142a6d02024-03-14T11:41:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13627251362725Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature reviewNengying Zhang0Nengying Zhang1Chengmin Luo2Jiayang Li3Yuxiang Bao4Zhongliang Yan5Xiaoming Cheng6Taolang Li7Junyuan Lv8Junyuan Lv9Department of General Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of General Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDrug Clinical Trial Institution, The Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of General Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of General Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of General Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of General Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of General Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, ChinaBackgroundEarly studies have revealed antagonistic effects associated with stacking chemotherapy (CT) and endocrine therapy (ET), thereby conventional wisdom does not advocate the simultaneous combination of these two treatment modalities. Limited clinical studies exist on the combined use of neoadjuvant CT (NACT) and neoadjuvant ET (NET), and there are no reported instances of concurrent neoadjuvant treatment for locally advanced breast cancer (LABC) using capecitabine and fulvestrant (FUL).Case presentationWe reported a 54-year-old woman who was diagnosed with hormone receptor-positive (HR+) LABC at our hospital. After neoadjuvant treatment involving two distinct CT regimens did not lead to tumor regression. Consequently, the patient was transitioned to concurrent capecitabine and FUL therapy. This change resulted in favorable pathological remission without any significant adverse events during treatment.ConclusionsA novel approach involving concurrent neoadjuvant therapy with CT and endocrine therapy may offer a potentially effective treatment avenue for some cases with HR+ LABC.https://www.frontiersin.org/articles/10.3389/fendo.2024.1362725/fullbreast cancerchemotherapyendocrine therapycapecitabinefulvestrant |
| spellingShingle | Nengying Zhang Nengying Zhang Chengmin Luo Jiayang Li Yuxiang Bao Zhongliang Yan Xiaoming Cheng Taolang Li Junyuan Lv Junyuan Lv Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature review Frontiers in Endocrinology breast cancer chemotherapy endocrine therapy capecitabine fulvestrant |
| title | Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature review |
| title_full | Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature review |
| title_fullStr | Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature review |
| title_full_unstemmed | Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature review |
| title_short | Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature review |
| title_sort | chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor positive local advanced breast cancer a case report and literature review |
| topic | breast cancer chemotherapy endocrine therapy capecitabine fulvestrant |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1362725/full |
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