The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure
Abstract Aims Measurement of B‐type natriuretic peptide (BNP) or N‐terminal pro‐BNP is recommended as part of the diagnostic workup of patients with suspected heart failure (HF). We evaluated the diagnostic and prognostic utility of the novel urinary proteomic classifier HF1, compared with BNP, in H...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-08-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.12708 |
| _version_ | 1818416812475285504 |
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| author | Ross T. Campbell Adam Jasilek Harald Mischak Esther Nkuipou‐Kenfack Agnieszka Latosinska Paul I. Welsh Colette E. Jackson Jane Cannon Alex McConnachie Christian Delles John J.V. McMurray |
| author_facet | Ross T. Campbell Adam Jasilek Harald Mischak Esther Nkuipou‐Kenfack Agnieszka Latosinska Paul I. Welsh Colette E. Jackson Jane Cannon Alex McConnachie Christian Delles John J.V. McMurray |
| author_sort | Ross T. Campbell |
| collection | DOAJ |
| description | Abstract Aims Measurement of B‐type natriuretic peptide (BNP) or N‐terminal pro‐BNP is recommended as part of the diagnostic workup of patients with suspected heart failure (HF). We evaluated the diagnostic and prognostic utility of the novel urinary proteomic classifier HF1, compared with BNP, in HF. HF1 consists of 85 unique urinary peptide fragments thought, mainly, to reflect collagen turnover. Methods and results We performed urinary proteome analysis using capillary electrophoresis coupled with mass spectrometry in 829 participants. Of these, 622 had HF (504 had chronic HF and 118 acute HF) and 207 were controls (62 coronary heart disease patients without HF and 145 healthy controls). The area under the receiver operating characteristic (ROC) curve (AUC) using HF1 for the diagnosis of HF (cases vs. controls) was 0.94 (95% CI, 0.92–0.96). This compared with an AUC for BNP of 0.98 (95% CI, 0.97–0.99). Adding HF1 to BNP increased the AUC to 0.99 (0.98–0.99), P < 0.001, and led to a net reclassification improvement of 0.67 (95% CI, 0.54–0.77), P < 0.001. Among 433 HF patients followed up for a median of 989 days, we observed 186 deaths. HF1 had poorer predictive value to BNP for all‐cause mortality and did not add prognostic information when combined with BNP. Conclusions The urinary proteomic classifier HF1 performed as well, diagnostically, as BNP and provided incremental diagnostic information when added to BNP. HF1 had less prognostic utility than BNP. |
| first_indexed | 2024-12-14T11:56:50Z |
| format | Article |
| id | doaj.art-ef46f42dcbe34cdba9bc08a266064c61 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-12-14T11:56:50Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-ef46f42dcbe34cdba9bc08a266064c612022-12-21T23:02:06ZengWileyESC Heart Failure2055-58222020-08-01741595160410.1002/ehf2.12708The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failureRoss T. Campbell0Adam Jasilek1Harald Mischak2Esther Nkuipou‐Kenfack3Agnieszka Latosinska4Paul I. Welsh5Colette E. Jackson6Jane Cannon7Alex McConnachie8Christian Delles9John J.V. McMurray10Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow G12 8TA UKRoberson Centre for Biostatistics University of Glasgow Glasgow UKInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow G12 8TA UKMosaiques Diagnostics GmbH Hannover GermanyMosaiques Diagnostics GmbH Hannover GermanyInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow G12 8TA UKQueen Elizabeth University Hospital Glasgow UKHarefield Hospital Harefield London UKRoberson Centre for Biostatistics University of Glasgow Glasgow UKInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow G12 8TA UKInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow G12 8TA UKAbstract Aims Measurement of B‐type natriuretic peptide (BNP) or N‐terminal pro‐BNP is recommended as part of the diagnostic workup of patients with suspected heart failure (HF). We evaluated the diagnostic and prognostic utility of the novel urinary proteomic classifier HF1, compared with BNP, in HF. HF1 consists of 85 unique urinary peptide fragments thought, mainly, to reflect collagen turnover. Methods and results We performed urinary proteome analysis using capillary electrophoresis coupled with mass spectrometry in 829 participants. Of these, 622 had HF (504 had chronic HF and 118 acute HF) and 207 were controls (62 coronary heart disease patients without HF and 145 healthy controls). The area under the receiver operating characteristic (ROC) curve (AUC) using HF1 for the diagnosis of HF (cases vs. controls) was 0.94 (95% CI, 0.92–0.96). This compared with an AUC for BNP of 0.98 (95% CI, 0.97–0.99). Adding HF1 to BNP increased the AUC to 0.99 (0.98–0.99), P < 0.001, and led to a net reclassification improvement of 0.67 (95% CI, 0.54–0.77), P < 0.001. Among 433 HF patients followed up for a median of 989 days, we observed 186 deaths. HF1 had poorer predictive value to BNP for all‐cause mortality and did not add prognostic information when combined with BNP. Conclusions The urinary proteomic classifier HF1 performed as well, diagnostically, as BNP and provided incremental diagnostic information when added to BNP. HF1 had less prognostic utility than BNP.https://doi.org/10.1002/ehf2.12708Heart failureBiomarkersProteomicsCollagenDiagnosisPrognosis |
| spellingShingle | Ross T. Campbell Adam Jasilek Harald Mischak Esther Nkuipou‐Kenfack Agnieszka Latosinska Paul I. Welsh Colette E. Jackson Jane Cannon Alex McConnachie Christian Delles John J.V. McMurray The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure ESC Heart Failure Heart failure Biomarkers Proteomics Collagen Diagnosis Prognosis |
| title | The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure |
| title_full | The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure |
| title_fullStr | The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure |
| title_full_unstemmed | The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure |
| title_short | The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure |
| title_sort | novel urinary proteomic classifier hf1 has similar diagnostic and prognostic utility to bnp in heart failure |
| topic | Heart failure Biomarkers Proteomics Collagen Diagnosis Prognosis |
| url | https://doi.org/10.1002/ehf2.12708 |
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