In silico analysis of overall survival with YBX1 in male and female solid tumours
Abstract The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology. Disparities in treatment outcomes between male and female cancer patients are increasingly reported. This study aimed...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-57771-y |
| _version_ | 1797233707974656000 |
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| author | David Robert Grimes Treewut Rassamegevanon Laure Marignol |
| author_facet | David Robert Grimes Treewut Rassamegevanon Laure Marignol |
| author_sort | David Robert Grimes |
| collection | DOAJ |
| description | Abstract The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology. Disparities in treatment outcomes between male and female cancer patients are increasingly reported. This study aimed to examine the relationship between YBX1 expression and overall survival in male and female patients with solid tumours. Overall survival and YBX1 expression data for cohorts of male and female cancer patients obtained from freely available databases were analysed with a cox proportional hazard model with covariates of biological sex and YBX1 expression. Kaplan–Meier curves and Violin plots were constructed for segregated male and female cohorts. High YBX1 expression was significantly associated with poor survival in 2 female-only and 4 mixed-sex cancer sites. In female lung cancer patients, better survival and lower YBX1 expression were identified. The clinical importance of YBX1 expression in cancer ought to be evaluated in a sex-specific manner, especially in lung cancer. |
| first_indexed | 2024-04-24T16:20:27Z |
| format | Article |
| id | doaj.art-ef4964139bd14a4fb88879a64b10a243 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T16:20:27Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ef4964139bd14a4fb88879a64b10a2432024-03-31T11:16:11ZengNature PortfolioScientific Reports2045-23222024-03-011411910.1038/s41598-024-57771-yIn silico analysis of overall survival with YBX1 in male and female solid tumoursDavid Robert Grimes0Treewut Rassamegevanon1Laure Marignol2Applied Radiation Therapy Trinity, Discipline of Radiation Therapy, Trinity College DublinOncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden–RossendorfApplied Radiation Therapy Trinity, Discipline of Radiation Therapy, Trinity College DublinAbstract The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology. Disparities in treatment outcomes between male and female cancer patients are increasingly reported. This study aimed to examine the relationship between YBX1 expression and overall survival in male and female patients with solid tumours. Overall survival and YBX1 expression data for cohorts of male and female cancer patients obtained from freely available databases were analysed with a cox proportional hazard model with covariates of biological sex and YBX1 expression. Kaplan–Meier curves and Violin plots were constructed for segregated male and female cohorts. High YBX1 expression was significantly associated with poor survival in 2 female-only and 4 mixed-sex cancer sites. In female lung cancer patients, better survival and lower YBX1 expression were identified. The clinical importance of YBX1 expression in cancer ought to be evaluated in a sex-specific manner, especially in lung cancer.https://doi.org/10.1038/s41598-024-57771-yY-box-binding protein 1SurvivalCancerBiological sex |
| spellingShingle | David Robert Grimes Treewut Rassamegevanon Laure Marignol In silico analysis of overall survival with YBX1 in male and female solid tumours Scientific Reports Y-box-binding protein 1 Survival Cancer Biological sex |
| title | In silico analysis of overall survival with YBX1 in male and female solid tumours |
| title_full | In silico analysis of overall survival with YBX1 in male and female solid tumours |
| title_fullStr | In silico analysis of overall survival with YBX1 in male and female solid tumours |
| title_full_unstemmed | In silico analysis of overall survival with YBX1 in male and female solid tumours |
| title_short | In silico analysis of overall survival with YBX1 in male and female solid tumours |
| title_sort | in silico analysis of overall survival with ybx1 in male and female solid tumours |
| topic | Y-box-binding protein 1 Survival Cancer Biological sex |
| url | https://doi.org/10.1038/s41598-024-57771-y |
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