tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
Mycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovisBCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use of synonymous codons in survival genes.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13302 |
| _version_ | 1819195223659511808 |
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| author | Yok Hian Chionh Megan McBee I. Ramesh Babu Fabian Hia Wenwei Lin Wei Zhao Jianshu Cao Agnieszka Dziergowska Andrzej Malkiewicz Thomas J. Begley Sylvie Alonso Peter C. Dedon |
| author_facet | Yok Hian Chionh Megan McBee I. Ramesh Babu Fabian Hia Wenwei Lin Wei Zhao Jianshu Cao Agnieszka Dziergowska Andrzej Malkiewicz Thomas J. Begley Sylvie Alonso Peter C. Dedon |
| author_sort | Yok Hian Chionh |
| collection | DOAJ |
| description | Mycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovisBCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use of synonymous codons in survival genes. |
| first_indexed | 2024-12-23T02:09:21Z |
| format | Article |
| id | doaj.art-ef49a7068372488eae9591272d451d23 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:09:21Z |
| publishDate | 2016-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ef49a7068372488eae9591272d451d232022-12-21T18:03:49ZengNature PortfolioNature Communications2041-17232016-11-017111210.1038/ncomms13302tRNA-mediated codon-biased translation in mycobacterial hypoxic persistenceYok Hian Chionh0Megan McBee1I. Ramesh Babu2Fabian Hia3Wenwei Lin4Wei Zhao5Jianshu Cao6Agnieszka Dziergowska7Andrzej Malkiewicz8Thomas J. Begley9Sylvie Alonso10Peter C. Dedon11Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and TechnologyInfectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyInfectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and TechnologyDepartment of Microbiology and Immunology Programme, Yong Loo Lin School of Medicine, 28 Medical Drive, Centre for Life Sciences, Level 3, National University of SingaporeInfectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and TechnologyInfectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and TechnologyInstitute of Organic Chemistry, Lodz University of TechnologyInstitute of Organic Chemistry, Lodz University of TechnologyCollege of Nanoscale Science and Engineering, State University of New YorkInfectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and TechnologyInfectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and TechnologyMycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovisBCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use of synonymous codons in survival genes.https://doi.org/10.1038/ncomms13302 |
| spellingShingle | Yok Hian Chionh Megan McBee I. Ramesh Babu Fabian Hia Wenwei Lin Wei Zhao Jianshu Cao Agnieszka Dziergowska Andrzej Malkiewicz Thomas J. Begley Sylvie Alonso Peter C. Dedon tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence Nature Communications |
| title | tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence |
| title_full | tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence |
| title_fullStr | tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence |
| title_full_unstemmed | tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence |
| title_short | tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence |
| title_sort | trna mediated codon biased translation in mycobacterial hypoxic persistence |
| url | https://doi.org/10.1038/ncomms13302 |
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