Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus-2 (SARS-CoV-2), is the most important health issue, internationally. With no specific and effective antiviral therapy for COVID-19, new or repurposed antiviral are urgently needed. Phytochemica...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/6/1775 |
| _version_ | 1797540525698449408 |
|---|---|
| author | Arumugam Vijaya Anand Balasubramanian Balamuralikrishnan Mohandass Kaviya Kathirvel Bharathi Aluru Parithathvi Meyyazhagan Arun Nachiappan Senthilkumar Shanmugam Velayuthaprabhu Muthukrishnan Saradhadevi Naif Abdullah Al-Dhabi Mariadhas Valan Arasu Mohammad Iqbal Yatoo Ruchi Tiwari Kuldeep Dhama |
| author_facet | Arumugam Vijaya Anand Balasubramanian Balamuralikrishnan Mohandass Kaviya Kathirvel Bharathi Aluru Parithathvi Meyyazhagan Arun Nachiappan Senthilkumar Shanmugam Velayuthaprabhu Muthukrishnan Saradhadevi Naif Abdullah Al-Dhabi Mariadhas Valan Arasu Mohammad Iqbal Yatoo Ruchi Tiwari Kuldeep Dhama |
| author_sort | Arumugam Vijaya Anand |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus-2 (SARS-CoV-2), is the most important health issue, internationally. With no specific and effective antiviral therapy for COVID-19, new or repurposed antiviral are urgently needed. Phytochemicals pose a ray of hope for human health during this pandemic, and a great deal of research is concentrated on it. Phytochemicals have been used as antiviral agents against several viruses since they could inhibit several viruses via different mechanisms of direct inhibition either at the viral entry point or the replication stages and via immunomodulation potentials. Recent evidence also suggests that some plants and its components have shown promising antiviral properties against SARS-CoV-2. This review summarizes certain phytochemical agents along with their mode of actions and potential antiviral activities against important viral pathogens. A special focus has been given on medicinal plants and their extracts as well as herbs which have shown promising results to combat SARS-CoV-2 infection and can be useful in treating patients with COVID-19 as alternatives for treatment under phytotherapy approaches during this devastating pandemic situation. |
| first_indexed | 2024-03-10T13:01:27Z |
| format | Article |
| id | doaj.art-ef4a773a45964e6097fe4e173aae30b3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:01:27Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ef4a773a45964e6097fe4e173aae30b32023-11-21T11:30:06ZengMDPI AGMolecules1420-30492021-03-01266177510.3390/molecules26061775Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2Arumugam Vijaya Anand0Balasubramanian Balamuralikrishnan1Mohandass Kaviya2Kathirvel Bharathi3Aluru Parithathvi4Meyyazhagan Arun5Nachiappan Senthilkumar6Shanmugam Velayuthaprabhu7Muthukrishnan Saradhadevi8Naif Abdullah Al-Dhabi9Mariadhas Valan Arasu10Mohammad Iqbal Yatoo11Ruchi Tiwari12Kuldeep Dhama13Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, IndiaDepartment of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul 05006, KoreaMedical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, IndiaMedical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, IndiaMedical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, IndiaDepartment of Life Sciences, CHRIST (Deemed to be University), Bengaluru 560029, IndiaInstitute of Forest Genetics and Tree Breeding (IFGTB), Forest Campus, Cowley Brown Road, RS Puram, Coimbatore 641002, IndiaDepartment of Biotechnology, Bharathiar University, Coimbatore 641046, IndiaDepartment of Biochemistry, Bharathiar University, Coimbatore 641046, IndiaDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaFaculty of Veterinary Sciences and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar 190006, IndiaDepartment of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura 281001, IndiaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, IndiaThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus-2 (SARS-CoV-2), is the most important health issue, internationally. With no specific and effective antiviral therapy for COVID-19, new or repurposed antiviral are urgently needed. Phytochemicals pose a ray of hope for human health during this pandemic, and a great deal of research is concentrated on it. Phytochemicals have been used as antiviral agents against several viruses since they could inhibit several viruses via different mechanisms of direct inhibition either at the viral entry point or the replication stages and via immunomodulation potentials. Recent evidence also suggests that some plants and its components have shown promising antiviral properties against SARS-CoV-2. This review summarizes certain phytochemical agents along with their mode of actions and potential antiviral activities against important viral pathogens. A special focus has been given on medicinal plants and their extracts as well as herbs which have shown promising results to combat SARS-CoV-2 infection and can be useful in treating patients with COVID-19 as alternatives for treatment under phytotherapy approaches during this devastating pandemic situation.https://www.mdpi.com/1420-3049/26/6/1775COVID-19medicinal plantsphytochemicalsherbsantiviral agentsSARS-CoV-2 |
| spellingShingle | Arumugam Vijaya Anand Balasubramanian Balamuralikrishnan Mohandass Kaviya Kathirvel Bharathi Aluru Parithathvi Meyyazhagan Arun Nachiappan Senthilkumar Shanmugam Velayuthaprabhu Muthukrishnan Saradhadevi Naif Abdullah Al-Dhabi Mariadhas Valan Arasu Mohammad Iqbal Yatoo Ruchi Tiwari Kuldeep Dhama Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2 Molecules COVID-19 medicinal plants phytochemicals herbs antiviral agents SARS-CoV-2 |
| title | Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2 |
| title_full | Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2 |
| title_fullStr | Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2 |
| title_full_unstemmed | Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2 |
| title_short | Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2 |
| title_sort | medicinal plants phytochemicals and herbs to combat viral pathogens including sars cov 2 |
| topic | COVID-19 medicinal plants phytochemicals herbs antiviral agents SARS-CoV-2 |
| url | https://www.mdpi.com/1420-3049/26/6/1775 |
| work_keys_str_mv | AT arumugamvijayaanand medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT balasubramanianbalamuralikrishnan medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT mohandasskaviya medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT kathirvelbharathi medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT aluruparithathvi medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT meyyazhaganarun medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT nachiappansenthilkumar medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT shanmugamvelayuthaprabhu medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT muthukrishnansaradhadevi medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT naifabdullahaldhabi medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT mariadhasvalanarasu medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT mohammadiqbalyatoo medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT ruchitiwari medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 AT kuldeepdhama medicinalplantsphytochemicalsandherbstocombatviralpathogensincludingsarscov2 |