A short peptide exerts neuroprotective effects on cerebral ischemia–reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis

A short peptide exerts neuroprotective effects on cerebral ischemia–reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis

Abstract Background Despite considerable efforts, ischemic stroke (IS) remains a challenging clinical problem. Therefore, the discovery of effective therapeutic and targeted drugs based on the underlying molecular mechanism is crucial for effective IS treatment. Methods A cDNA-encoding peptide was c...

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Bibliographic Details
Main Authors: Yilin Li, Tao Jin, Naixin Liu, Junsong Wang, Zihan Qin, Saige Yin, Yingxuan Zhang, Zhe Fu, Yutong Wu, Yinglei Wang, Yixiang Liu, Meifeng Yang, Ailan Pang, Jun Sun, Ying Wang, Xinwang Yang
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic stroke
Peptide
miR-6328
Neuroprotection
IKKβ
NF-κB
Online Access:https://doi.org/10.1186/s12974-023-02739-4

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