Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies

Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies

Thirteen benzylethoxyaryl ureas have been synthesized and biologically evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins to overcome resistance phenomena offered by cancer. The antiproliferative activity of these molecules on several tumor cell lines (HT-29 and A549), on the endothel...

Full description

Bibliographic Details
Main Authors:	Raquel Gil-Edo, German Hernández-Ribelles, Santiago Royo, Natasha Thawait, Alan Serrels, Miguel Carda, Eva Falomir
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Series:	International Journal of Molecular Sciences
Subjects:	aryl urea benzylethoxyaryl urea angiogenesis PD-L1 VEGFR-2 TLCRs
Online Access:	https://www.mdpi.com/1422-0067/24/10/8582

Similar Items

Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies
by: Celia Martín-Beltrán, et al.
Published: (2021-04-01)

Unveiling the Potential of BenzylethyleneAryl–Urea Scaffolds for the Design of New Onco Immunomodulating Agents
by: Raquel Gil-Edo, et al.
Published: (2023-05-01)

Antimicrobial and anthelmintic activities of aryl urea agents
by: Pedro Ernesto de Resende, et al.
Published: (2023-06-01)

Green Urea : for Future Sustainability /
by: Yahya, Noorhana, author
Published: (2018)

Urea in perspective
Published: (1988)

Formation of urea planar in urea crystal : a computational study /
by: Siti Fatimah Zaharah Mustafa, 1987-, et al.
Published: (2012)

Methods of test for urea
by: 8096 British Standards Institution

Formation of urea planar in urea crystal : a computational study [electronic resource] /
by: Siti Fatimah Zaharah Mustafa, 1987-
Published: (2012)

Milk Urea Dynamics during its Transformation into Yogurt
by: Cornelia Vintilă, et al.
Published: (2023-11-01)

Preparation and Characterization of Urea with Coated-Urea Materials and their Performance to Reduce Ammonia Volatilization and Improve Crop Production
by: Junejo, Nasima
Published: (2011)

Studies on comparison of nano-urea and prilled urea for enhancing maize (Zea mays) growth and productivity
by: SATYAM RAWAT, et al.
Published: (2024-03-01)

Melting and Heat Transfer Characteristics of Urea Water Solution According to a Heating Module’s Operating Conditions in a Frozen Urea Tank
by: Byeong Gyu Jeong, et al.
Published: (2021-12-01)

Design, synthesis and biological evaluation of aryl urea derivatives of oxazole-pyrimidine as anticancer agents
by: Veeranjaneyulu Pattabi, et al.
Published: (2024-01-01)

Multialgorithm-Based Docking Reveals Imidazolidinyl Urea as a Multitargeted Inhibitor for Lung Cancer
by: Shaban Ahmad, et al.
Published: (2023-03-01)

Development of coating technology using rotary pan for production of slow-release urea
by: Babadi, Farahnaz Eghbali
Published: (2015)

The use of urea nitrogen for pasture and fodder production /
by: 210150 Chin, Fook Yuen
Published: (1979)

Microbial Degradation of Urea from Urea Bearing Wastewaters
by: P. P. Pathe, et al.
Published: (2001-03-01)

Improved Synthesis of Unsymmetrical Ureas via Carbamates
by: Ramteke Prachi, et al.
Published: (2023-10-01)

A Structure-Based Mechanism for the Denaturing Action of Urea, Guanidinium Ion and Thiocyanate Ion
by: Antonella Paladino, et al.
Published: (2022-12-01)

Development of a paper strip test for colorimetric detection of urea in raw materials for animal feed
by: Chuthamart Chanawanno, et al.
Published: (2023-06-01)

Intercalation of urea between kaolinite nanolayers for controlled release fertilizer application
by: Mahdavi, Fariba
Published: (2012)

Effectiveness of sulfur-coated and uncoated urea fertilizers as nitrogen sources for rice
by: Said, Nur Fazlina
Published: (2012)

Utilizing Urea–Chitosan Nanohybrid for Minimizing Synthetic Urea Application and Maximizing <i>Oryza sativa</i> L. Productivity and N Uptake
by: Omnia M. Elshayb, et al.
Published: (2022-06-01)

Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents
by: Maxim Oshchepkov, et al.
Published: (2022-06-01)

Numerical evaluation of urea-mixing devices for close-coupled selective catalytic reduction systems
by: Bartosz Grzegorz Kaźmierski, et al.
Published: (2023-04-01)

Dried of Poultry Waste Urea-Molasses Block (dpw-umb) as Potential for Feed Supplementation
by: Danung Nur Adli, et al.
Published: (2017-10-01)

Fibrinogen-to-Albumin Ratio and Blood Urea Nitrogen-to-Albumin Ratio in COVID-19 Patients: A Systematic Review and Meta-Analysis
by: Juan R. Ulloque-Badaracco, et al.
Published: (2022-07-01)

Effects of coated urea fertilizers on growth and yield of MR219 rice (Oryza sativa L.)
by: A. Rahman, Nur Syamimi
Published: (2016)

Insights into the synergistic effect between nickel and molybdenum for catalyzing urea electrooxidation
by: Jiaqi Wang, et al.
Published: (2022-12-01)

Milk Urea Disappears During Milk Processing into Cheese
by: Cornelia Vintilă, et al.
Published: (2023-11-01)

Large scale uniform Ni-P plated carbon fiber for boosting urea electro-oxidation and electro-detection
by: Yan-Ru Fan, et al.
Published: (2023-10-01)

Comparative Study Effect of Urea-Sulfur Fertilizers on Nitrogen Uptake and Maize Productivity
by: Samar Swify, et al.
Published: (2022-11-01)

Design, Synthesis and Anticancer Activity of a New Series of <i>N</i>-aryl-<i>N</i>′-[4-(pyridin-2-ylmethoxy)benzyl]urea Derivatives
by: Shicheng Hou, et al.
Published: (2021-06-01)

Evaluation of enhanced efficient fertilizer urea on rice production and environment
by: Hashim, Mohammad Mu'az
Published: (2016)

Polyurethane Recycling: Thermal Decomposition of 1,3-Diphenyl Urea to Isocyanates
by: Shahab Zamani, et al.
Published: (2023-05-01)

Coupling of NiFe Layered Double Hydroxides with Sulfides for Highly Efficient Urea Electrolysis and Hydrogen Evolution
by: Wenxian Liu, et al.
Published: (2023-01-01)

Effects of peat derived humic acid on ammonia volatilization from urea fertilizer
by: Lee, Jia Huey
Published: (2011)

Selective and low-cost triterpene urea and amide derivatives of high cytotoxicity and selectivity
by: Benjamin Brandes, et al.
Published: (2022-01-01)

Diarylureas: New Promising Small Molecules against <i>Streptococcus mutans</i> for the Treatment of Dental Caries
by: Domenico Iacopetta, et al.
Published: (2023-01-01)

Novel Poly(ester urethane urea)/Polydioxanone Blends: Electrospun Fibrous Meshes and Films
by: Kiran R. Adhikari, et al.
Published: (2021-06-01)