MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise

MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise

Diabetic muscle atrophy is an inflammation-related complication of type-2 diabetes mellitus (T2DM). Even though regular exercise prevents further deterioration of atrophic status, there is no effective mediator available for treatment and the underlying cellular mechanisms are less explored. In this...

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Bibliographic Details
Main Authors: Xiaoyu Yan, Pengyu Fu, Yimin Zhang, Dongmei Ling, Lewis Reynolds, Weicheng Hua, Zhiyuan Wang, Fangyuan Ma, Boxuan Li, Jingjing Yu, Yujia Liu, Lijing Gong, Enming Zhang
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
diabetes
muscle atrophy
MCC950
NLRP3
pyroptosis
aerobic exercise
Online Access:https://www.mdpi.com/1420-3049/29/3/712

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