Virulence and Cross-Protection Conferred by an Attenuated Genotype I-Based Chimeric Japanese Encephalitis Virus Strain Harboring the E Protein of Genotype V in Mice

Virulence and Cross-Protection Conferred by an Attenuated Genotype I-Based Chimeric Japanese Encephalitis Virus Strain Harboring the E Protein of Genotype V in Mice

ABSTRACT Japanese encephalitis virus (JEV) genotype V (GV) emerged in China in 2009, then South Korea, and has since spread to other regions in Asia and beyond, raising concern about its pathogenicity and the cross-protection offered by JEV vaccines against different genotypes. In this study, we rep...

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Bibliographic Details
Main Authors: Qiqi Xia, Yan Zhang, Yang Yang, Xiaochun Ma, Zhixin Guan, Junjie Zhang, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Jianchao Wei, Zhiyong Ma
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
Japanese encephalitis virus
genotype V
virulence
vaccine
cross-protection
toxicity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01990-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01990-22

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