The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea
The objective: to study the effect of sleep-related breathing disorders on the activation of blood coagulation reactions associated with systemic inflammation in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea.Subjects and methods. An open prospective compa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2020-05-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1414 |
| _version_ | 1826563021728645120 |
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| author | I. Ya. Tseymakh Ya. N. Shoykhet A. E. Tseymakh |
| author_facet | I. Ya. Tseymakh Ya. N. Shoykhet A. E. Tseymakh |
| author_sort | I. Ya. Tseymakh |
| collection | DOAJ |
| description | The objective: to study the effect of sleep-related breathing disorders on the activation of blood coagulation reactions associated with systemic inflammation in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea.Subjects and methods. An open prospective comparative study analyzed thrombogenic risk factors, markers of inflammation and insulin resistance in 65 patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea, 26 of them received non-invasive ventilation as a part of their therapy (main group).Results. The blood levels of homocysteine and prothrombin fragments 1+2 are closely associated with the duration of nocturnal hypoxemia, concentrations of C-reactive protein, C-peptide, and endothelial vascular growth factor and can be managed with CPAP therapy.The authors state that they have no conflict of interests. |
| first_indexed | 2024-03-12T03:30:22Z |
| format | Article |
| id | doaj.art-ef4f722499464172ab2397a8964258bf |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2025-03-14T09:57:21Z |
| publishDate | 2020-05-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-ef4f722499464172ab2397a8964258bf2025-03-02T11:22:32ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062020-05-01984243110.21292/2075-1230-2020-98-4-24-311413The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apneaI. Ya. Tseymakh0Ya. N. Shoykhet1A. E. Tseymakh2Altai State Medical UniversityAltai State Medical UniversityAltai State Medical UniversityThe objective: to study the effect of sleep-related breathing disorders on the activation of blood coagulation reactions associated with systemic inflammation in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea.Subjects and methods. An open prospective comparative study analyzed thrombogenic risk factors, markers of inflammation and insulin resistance in 65 patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea, 26 of them received non-invasive ventilation as a part of their therapy (main group).Results. The blood levels of homocysteine and prothrombin fragments 1+2 are closely associated with the duration of nocturnal hypoxemia, concentrations of C-reactive protein, C-peptide, and endothelial vascular growth factor and can be managed with CPAP therapy.The authors state that they have no conflict of interests.https://www.tibl-journal.com/jour/article/view/1414chronic obstructive pulmonary diseaseobstructive sleep apneahomocysteineendothelial vascular growth factor |
| spellingShingle | I. Ya. Tseymakh Ya. N. Shoykhet A. E. Tseymakh The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea Туберкулез и болезни лёгких chronic obstructive pulmonary disease obstructive sleep apnea homocysteine endothelial vascular growth factor |
| title | The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea |
| title_full | The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea |
| title_fullStr | The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea |
| title_full_unstemmed | The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea |
| title_short | The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea |
| title_sort | role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea |
| topic | chronic obstructive pulmonary disease obstructive sleep apnea homocysteine endothelial vascular growth factor |
| url | https://www.tibl-journal.com/jour/article/view/1414 |
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