Evaluation of Natural and Vaccine-Induced Anti-SARS-CoV-2 Immunity: A Comparative Study between Different Groups of Volunteers
(1) Background: The production of anti-SARS-CoV-2 antibodies should help minimize the severity of COVID-19 disease. Our focus was to investigate and compare different vaccination schedules, monitoring circulating S-RBD Ab (antibodies anti—Spike protein—Receptor Binding Domain) levels after administe...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/10/2/25 |
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| author | Maria Caterina Schipani Flaminia Tomassetti Isabella Polidori Paola Ricci Maria Loredana Frassanito Silva Seraceni Maria Morello Eleonora Nicolai Stefano Aquaro Sergio Bernardini Massimo Pieri Graziella Calugi |
| author_facet | Maria Caterina Schipani Flaminia Tomassetti Isabella Polidori Paola Ricci Maria Loredana Frassanito Silva Seraceni Maria Morello Eleonora Nicolai Stefano Aquaro Sergio Bernardini Massimo Pieri Graziella Calugi |
| author_sort | Maria Caterina Schipani |
| collection | DOAJ |
| description | (1) Background: The production of anti-SARS-CoV-2 antibodies should help minimize the severity of COVID-19 disease. Our focus was to investigate and compare different vaccination schedules, monitoring circulating S-RBD Ab (antibodies anti—Spike protein—Receptor Binding Domain) levels after administering two doses in naïve patients. Likewise, vaccine-stimulated immunity in naïve and previously infected patients was compared. (2) Methods: We included 392 patients. Sera were evaluated by Elecsys anti-SARS-CoV-2 S. Statistical analyses were conducted by MedCalc and JASP. (3) Results: In COVID-19 patients, the median value of Ab levels was 154 BAU/mL, stable up to 9 months after the infection. From the data observed in vaccinated patients, higher median values were recorded in COVID-19/Pfizer BioNTech (18913 BAU/mL) than in other groups (Pfizer BioNTech: 1841; ChadOx1 961; heterologous vaccination: 2687) BAU/mL. (4) Conclusions: In conclusion, a single booster dose given to previously infected patients raised an antibody response much higher than two doses given to naïve individuals and heterologous vaccination generated a robust persistent antibody response at high levels, steady up to three months after administration. |
| first_indexed | 2024-03-09T23:59:52Z |
| format | Article |
| id | doaj.art-ef4fbd7ef0dd45baaf2f98aa61754770 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-09T23:59:52Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-ef4fbd7ef0dd45baaf2f98aa617547702023-11-23T16:19:30ZengMDPI AGDiseases2079-97212022-04-011022510.3390/diseases10020025Evaluation of Natural and Vaccine-Induced Anti-SARS-CoV-2 Immunity: A Comparative Study between Different Groups of VolunteersMaria Caterina Schipani0Flaminia Tomassetti1Isabella Polidori2Paola Ricci3Maria Loredana Frassanito4Silva Seraceni5Maria Morello6Eleonora Nicolai7Stefano Aquaro8Sergio Bernardini9Massimo Pieri10Graziella Calugi11Lifebrain Cosenza—Bilotta, 87100 Cosenza, ItalyDepartment of Experimental Medicine, University of Tor Vergata, 00133 Rome, ItalyLifebrain s.r.l., Viale Roma 190/A, 00012, Guidonia Montecelio, 00133 Rome, ItalyLifebrain Cosenza—Bilotta, 87100 Cosenza, ItalyLifebrain s.r.l., Viale Roma 190/A, 00012, Guidonia Montecelio, 00133 Rome, ItalyR.D.I. Lifebrain, Limena, 35010 Padua, ItalyDepartment of Experimental Medicine, University of Tor Vergata, 00133 Rome, ItalyDepartment of Experimental Medicine, University of Tor Vergata, 00133 Rome, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87100 Cosenza, ItalyDepartment of Experimental Medicine, University of Tor Vergata, 00133 Rome, ItalyDepartment of Experimental Medicine, University of Tor Vergata, 00133 Rome, ItalyLifebrain s.r.l., Viale Roma 190/A, 00012, Guidonia Montecelio, 00133 Rome, Italy(1) Background: The production of anti-SARS-CoV-2 antibodies should help minimize the severity of COVID-19 disease. Our focus was to investigate and compare different vaccination schedules, monitoring circulating S-RBD Ab (antibodies anti—Spike protein—Receptor Binding Domain) levels after administering two doses in naïve patients. Likewise, vaccine-stimulated immunity in naïve and previously infected patients was compared. (2) Methods: We included 392 patients. Sera were evaluated by Elecsys anti-SARS-CoV-2 S. Statistical analyses were conducted by MedCalc and JASP. (3) Results: In COVID-19 patients, the median value of Ab levels was 154 BAU/mL, stable up to 9 months after the infection. From the data observed in vaccinated patients, higher median values were recorded in COVID-19/Pfizer BioNTech (18913 BAU/mL) than in other groups (Pfizer BioNTech: 1841; ChadOx1 961; heterologous vaccination: 2687) BAU/mL. (4) Conclusions: In conclusion, a single booster dose given to previously infected patients raised an antibody response much higher than two doses given to naïve individuals and heterologous vaccination generated a robust persistent antibody response at high levels, steady up to three months after administration.https://www.mdpi.com/2079-9721/10/2/25vaccineSARS-CoV-2antibodiesimmunology |
| spellingShingle | Maria Caterina Schipani Flaminia Tomassetti Isabella Polidori Paola Ricci Maria Loredana Frassanito Silva Seraceni Maria Morello Eleonora Nicolai Stefano Aquaro Sergio Bernardini Massimo Pieri Graziella Calugi Evaluation of Natural and Vaccine-Induced Anti-SARS-CoV-2 Immunity: A Comparative Study between Different Groups of Volunteers Diseases vaccine SARS-CoV-2 antibodies immunology |
| title | Evaluation of Natural and Vaccine-Induced Anti-SARS-CoV-2 Immunity: A Comparative Study between Different Groups of Volunteers |
| title_full | Evaluation of Natural and Vaccine-Induced Anti-SARS-CoV-2 Immunity: A Comparative Study between Different Groups of Volunteers |
| title_fullStr | Evaluation of Natural and Vaccine-Induced Anti-SARS-CoV-2 Immunity: A Comparative Study between Different Groups of Volunteers |
| title_full_unstemmed | Evaluation of Natural and Vaccine-Induced Anti-SARS-CoV-2 Immunity: A Comparative Study between Different Groups of Volunteers |
| title_short | Evaluation of Natural and Vaccine-Induced Anti-SARS-CoV-2 Immunity: A Comparative Study between Different Groups of Volunteers |
| title_sort | evaluation of natural and vaccine induced anti sars cov 2 immunity a comparative study between different groups of volunteers |
| topic | vaccine SARS-CoV-2 antibodies immunology |
| url | https://www.mdpi.com/2079-9721/10/2/25 |
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