Downregulation of PPARα during Experimental Left Ventricular Hypertrophy is Critically Dependent on Nox2 NADPH Oxidase Signalling

Downregulation of PPARα during Experimental Left Ventricular Hypertrophy is Critically Dependent on Nox2 NADPH Oxidase Signalling

Pressure overload-induced left ventricular hypertrophy (LVH) is initially adaptive but ultimately promotes systolic dysfunction and chronic heart failure. Whilst underlying pathways are incompletely understood, increased reactive oxygen species generation from Nox2 NADPH oxidases, and metabolic remo...

Full description

Bibliographic Details
Main Authors: Adam P. Harvey, Emma Robinson, Kevin S. Edgar, Ross McMullan, Karla M. O’Neill, Matthew Alderdice, Raheleh Amirkhah, Philip D. Dunne, Barbara J. McDermott, David J. Grieve
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
Nox2 NADPH oxidase
PPARα
left ventricular hypertrophy
oxidative stress
microarray
transverse aortic constriction
Online Access:https://www.mdpi.com/1422-0067/21/12/4406

Internet

https://www.mdpi.com/1422-0067/21/12/4406

Similar Items